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All Journal Jurnal Ilmu Kesehatan Jurnal Kedokteran Mulawarman Jurnal Sains dan Kesehatan
Siagian, Loly Rotua Dharmanita
Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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GAMBARAN PROFIL LIPID DAN RASIO LIPID PADA PASIEN STROKE ISKEMIK BERULANG DI RSUD ABDUL WAHAB SJAHRANIE SAMARINDA Muhammad Fadlan Adam; Yetty Octavia Hutahaean; Loly Rotua Dharmanita Siagian
Jurnal Kedokteran Mulawarman Vol 7, No 2 (2020): Jurnal Kedokteran Mulawarman
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/j.ked.mulawarman.v7i2.4293

Abstract

Stroke iskemik merupakan tipe stroke yang paling sering terjadi pada serangan berulang. Subtipe yang paling sering terjadi adalah aterosklerosis arteri besar yang menyebabkan oklusi arteri pada otak. Abnormalitas lipid plasma merupakan penyebab utama terjadinya aterosklerosis. Rasio lipid dapat menginformasikan risiko aterosklerosis yang sulit diukur dengan pemeriksaan rutin dan peningkatan rasio lipid menggambarkan ketidakseimbangan antara fraksi lipid aterogenik dan antiaterogenik. Penelitian ini bertujuan untuk mengetahui gambaran profil lipid dan rasio lipid pada pasien stroke iskemik berulang di RSUD Abdul Wahab Sjahranie Samarinda. Penelitian ini bersifat deskriptif dengan desain studi cross sectional. Pengambilan sampel secara purposive sampling pada pasien stroke iskemik yang mempunyai riwayat stroke iskemik sebelumnya sebanyak 71 sampel. Pengambilan data profil lipid menggunakan data sekunder dari rekam medik dan rasio lipid didasarkan pada perbandingan kolesterol total (K-Total)/kolesterol high density lipoprotein (K-HDL), kolesterol low density lipoprotein (K-LDL)/K-HDL, dan trigliserida (TG)/K-HDL. Pada penelitian ini didapatkan hasil pasien stroke iskemik berulang paling banyak dengan K-Total yang optimal sebesar 49,3%, K-LDL mendekati optimal 42,2%, K-HDL rendah 71,8%, TG optimal 62,0%, rasio K-Total/K-HDL di atas nilai risiko 76,1%, rasio K-LDL/K-HDL di atas nilai risiko 63,4%, dan rasio TG/K-HDL di atas nilai risiko 52,1%. Berdasarkan hasil ini dapat disimpulkan bahwa profil lipid pasien stroke iskemik berulang di RSUD Abdul Wahab Sjahranie Samarinda paling banyak ditemukan dengan kadar K-Total dan TG yang optimal, K-LDL yang mendekati optimal, dan kadar K-HDL yang rendah. Rasio lipid yang terdiri dari rasio K-Total/K-HDL, rasio K-LDL/K-HDL dan rasio TG/K-HDL masing-masing ditemukan paling banyak dengan rasio di atas nilai risiko.
The RELATIONSHIP BETWEEN TYPES OF PLASMODIUM FALCIPARUM AND PLASMODIUM VIVAX WITH THE DEGREE OF THROMBOCYTOPENIA IN MALARIA PATIENTS AT RSUD RATU AJI PUTRI BOTUNG PENAJAM PASER UTARA Doni Suryadi; Vera Madonna Lumban Toruan; Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian
Jurnal Ilmu Kesehatan Vol 9 No 1 (2021): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v9i1.2218

Abstract

Malaria is a tropical infectious disease with high morbidity and mortality rates. In malaria, various kinds of haematological complications can arise, one of which is thrombocytopenia. Thrombocytopenia is most commonly encountered during acute malaria infection with varying degrees observed in both Plasmodium falciparum and Plasmodium vivax infections. The purpose of this study was to determine the relationship between the types of Plasmodium falciparum and Plasmodium vivax with the degree of thrombocytopenia in malaria patients at the Ratu Aji Putri Botung Penajam Paser Utara Hospital. This research is an observasional analytic study with cross sectional method. The data was taken by using purposive sampling method from the medical records of malaria patients hospitalized in Ratu Aji Putri Botung Penajam Paser Utara Hospital in the period of January 2013 - August 2018. Data analysis used the Chi-square test. Of the 310 malaria patients who were study subjects, 60,3% (n = 187) were infected with Plasmodium falciparum and 39,7% (n = 123) were infected with Plasmodium vivax. Most of the research subjects were male (95,8%) who were dominated by adults (56,5%). As many as 90% of malaria patients experienced thrombocytopenia with mild, moderate, and severe thrombocytopenia respectively 29,4% ; 56,6% ; 14,0%. Severe thrombocytopenia was more common in falciparum malaria patients (16,4%). The statistical test result for the type of Plasmodium with the degree of thrombocytopenia were p = 0,139. It was concluded that there was no relationship between the types of Plasmodium falciparum and Plasmodium vivax with the degree of thrombocytopenia in malaria patients.
Hubungan Jenis Plasmodium falciparum dan Plasmodium vivax dengan Kejadian Anemia pada Pasien Malaria di RSUD Ratu Aji Putri Botung Penajam Paser Utara: Relationship between Plasmodium falciparum and Plasmodium vivax Types with the Incidence of Anemia in Malaria Patients at Ratu Aji Putri Botung Hospital, Penajam Paser Utara Doni Suryadi; Vera Madonna Lumban Toruan; Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v3i2.283

Abstract

Malaria is a disease caused by Plasmodium infection that is still a health problem in the tropical area including Indonesia. Penajam Paser Utara is the only district with a high level of malaria endemicity outside eastern of Indonesia which is located at the Province of East Kalimantan. Malaria can cause various complications including haematological abnormalities. Haematological abnormalities that are often found in both falciparum malaria and vivax malaria is anaemia. The purpose of this study was to determine the relationship between the types of Plasmodium falciparum and Plasmodium vivax with the incidence of anaemia in malaria patients at Ratu Aji Putri Botung, Penajam Paser Utara hospital. This research is an observational analytic study with cross sectional method. The data was obtained from medical records of hospitalized malaria patients at Ratu Aji Putri Botung Penajam Paser Utara hospital in the period of January 2013 – August 2018 by purposive sampling method. The data were analyzed using the Chi-square test. The subjects of the study were 310 malaria patients consisting of 60,3% (n=187) patients infected with Plasmodium falciparum and 39,7% (n=123) patients infected with Plasmodium vivax. The majority of research subjects were male (95,8%) and were in the 26 – 40 years age group (56,5%). Anaemia was found in 49% of malaria patients dominated by vivax malaria patients (52%). Statistical test result between types of Plasmodium with the incidence of anaemia was p = 0,391. It was concluded that there was no association between the types of Plasmodium falciparum and Plasmodium vivax with the incidence of anaemia in malaria patients.
DILEMA KORTIKOSTEROID : ASMA BRONKIAL TIDAK TERKONTROL AKIBAT DIGANTI DENGAN PEMAKAIAN STEROID SISTEMIK JANGKA PANJANG Sachio, Alvin; Silalahi, Mauritz; Siagian, Loly Rotua Dharmanita
Jurnal Kedokteran Mulawarman Vol 13, No 1 (2026): Jurnal Kedokteran Mulawarman
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v13i1.26409

Abstract

AbstrakLatar Belakang : Asma adalah penyakit inflamasi kronik saluran napas yang menjadi masalah kesehatan global dengan angka morbiditas dan mortalitas yang signifikan. Kortikosteroid merupakan terapi lini pertama yang paling efektif untuk mengendalikan gejala dan menurunkan inflamasi melalui mekanisme molekuler transaktivasi dan transpresi. Meskipun demikian, tantangan klinis muncul dengan adanya fenomena resistensi atau sensitivitas rendah terhadap kortikosteroid pada kasus asma berat, yang sering dikaitkan dengan faktor stres oksidatif dan penurunan enzim histone deacetylase (HDAC). Kasus : Studi observasional deskriptif ini melaporkan satu kasus seorang pria usia 66 tahun dengan asma eksaserbasi akut berat dengan derajat asma tidak terkontrol di rumah sakit Dirgahayu Samarinda, Indonesia. Data klinis, radiologi, spirometri diambil dari rekam medis. Kesimpulan : Kortikosteroid adalah terapi jangka panjang paling efektif untuk asma Th2, namun sebagian pasien mengalami penurunan respons atau resistensi akibat faktor stres oksidatif dan penurunan enzim HDAC. Studi kasus ini menyoroti pasien dengan asma tak terkontrol, penggunaan jangka panjang kortikostreoid, dan efek samping yang terjadi, menunjukkan indikasi kuat resistensi kortikosteroid karena terapi lini pertama tidak lagi memberikan perbaikan klinis. 
Co-Authors Doni Suryadi Doni Suryadi Fransiska Anggreni Sihotang Ibrahim, Arie Kalalo, Lily Pertiwi Muhammad Fadlan Adam Novia Fransiska Ngo Rivaldi, Achmad Sachio, Alvin Silalahi, Mauritz Vera Madonna Lumban Toruan Yetty Octavia Hutahaean