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All Journal Jurnal Ilmiah Manuntung Jurnal Ilmu Kesehatan Jurnal Kedokteran Mulawarman Jurnal Sains dan Kesehatan
Siagian, Loly Rotua Dharmanita
Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Jurnal Ilmiah Manuntung

 1 
SKRINING THALASEMIA-BETA MINOR PADA MAHASISWA FAKULTAS KEDOKTERAN Sihotang, Fransiska Anggreni; Siagian, Loly Rotua Dharmanita; Ngo, Novia Fransiska; Kalalo, Lily Pertiwi
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

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Abstract

Thalassemia is a group of congenital hemoglobinopathy characterized by deficiency or absence of one (or more) of the globin chains that constitute hemoglobin. Thalassemia major is inherited through autosomal recessive pattern by marriage between carriers of the thalassemia gene known as thalassemia minor. Beta-thalassemia is the most common type of thalassemia. It is estimated that 10% of Indonesia's population carries the beta-thalassemia gene. However, there has been no routine screening for thalassemia gene carriers. Several recognized methods of thalassemia screening are available. One of them is screening of prospective brides using several hematology parameters such as Mentzer index and red blood cells fragility; both are relatively straightforward and inexpensive compared to hemoglobin analysis or genetic testing. This study aimed to determine the frequency of beta-thalassemia minor suspects among students in the Medical Faculty of Mulawarman University. This study was a descriptive quantitative study with cross sectional approach that involved 160 participants. Participant's blood sample was collected for complete blood count and one tube osmotic fragility test (OTOFT). Mentzer index is calculated by dividing MCV values ??with erythrocyte count. Participants were determined as beta-thalassemia minor suspects if they met following criterias: (1) MCV < 80 fL; (2) Mentzer index < 13; and (3) positive OTOFT result. This study demonstrated that 1.25% (n=2) of 160 participants were beta-thalassemia minor suspect. Further examination of hemoglobin electrophoresis or genetic testing is needed to further confirm this finding.
Hubungan Kadar Natrium Serum dengan Outcome Klinis pada Pasien Cedera Kepala Berat di RSUD Abdul Wahab Sjahranie Samarinda Rivaldi, Achmad; Ibrahim, Arie; Siagian, Loly Rotua Dharmanita
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.125 KB) | DOI: 10.51352/jim.v6i1.296

Abstract

Recently, Traumatic Brain Injury (TBI) has high mortality in the world. In severe TBI, secondary brain injury can occur. ElectrSolyte disorders are the most common in secondary brain insult especially sodium disorders. It remains unclear whether hyponatremia or hypernatremia can cause worse clinical outcome in TBI patients. This study aimed to determine association between serum sodium level with clinical outcome in severe TBI patients at RSUD Abdul Wahab Sjahranie Samarinda. A cross sectional analytical study by taking samples to the patients with diagnosed severe TBI (GCS ≤ 8) which were hospitalized at RSUD Abdul Wahab Sjahranie Samarinda in the period of January-December 2018 that complied inclusion and exclusion criteria. Research variables are sodium serum level and clinical outcome that was assessed by structured interviews for Glasgow Outcome Scale (GOS). The relationship between variables was done using the Fisher's Exact test. A total of 41 severe TBI patients were administered. The characteristics of the sample were the most patients in 20s-40s (46.3%), patients were dominated by male (82.9%) and the most common CT scan characteristic were epidural hematoma (29.3%). The most of patients showed normonatremia in 25 patients (61%), 9 patients (22%) had hypernatremia and 7 patients (17.1%) had hyponatremia. The most clinical outcome on severe TBI patients were worse outcome with 70.7% while good outcome with 29.3%. Statistical result showed there’s no association between serum sodium level (hyponatremia and hypernatremia) with clinical outcome in severe TBI patients with p values, 1.000 and 0.225, respectively. There’s no association between serum sodium level with clinical outcome in severe TBI patients.
Co-Authors Doni Suryadi Doni Suryadi Fransiska Anggreni Sihotang Ibrahim, Arie Kalalo, Lily Pertiwi Muhammad Fadlan Adam Novia Fransiska Ngo Rivaldi, Achmad Vera Madonna Lumban Toruan Yetty Octavia Hutahaean