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All Journal Jambura Journal of Chemistry Health Sciences and Pharmacy Journal Acta Holistica Pharmaciana Borneo Journal of Pharmacy Dharma: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Esati, Ni Ketut
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Analisis Mutu Minyak Zaitun Yang Diperoleh Dari Buah Zaitun (Olea eurofaea) Dan Aplikasinya Sebagai Antikolesterol Duwi Cahyadi, Kadek; Dewi Lestari, Gusti Ayu; Esati, Ni Ketut
Jambura Journal of Chemistry Vol 5, No 1 (2023): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v5i1.16767

Abstract

Olive oil is oil obtained from olives (Olea europaea L.). Olive oil contains high in oleic acid so it can be used as an anticholesterol. This study aims to determine the quality of olive oil according to SNI 01-4474-1998 and its anticholesterol activity by UV-Vis spectrophotometry. In this research, olive oil quality test was conducted, namely water content test using the thermogravimetric method, fatty acid content test using an alkalimetric titration method based on an acid-base reaction, saponification test using the acidimetric method, and iodine number test using the iodometric titration method. The method of testing the anticholesterol activity of olive oil was carried out in vitro using Lieberman-Burchard reagent. The results of the quality test on olive oil obtained water content of 0.03%, free fatty acids 1.73%, saponification number 190.90 mgKOH/g, iodine number 91.25g iodine/100g, where these results have met the SNI 01-4474-1998 standard. The results of the anticholesterol test showed a decrease in free cholesterol levels by 39.76%. Olive oil shows anticholesterol activity due to the presence of oleic acid or MUFA (Mono Unsaturated Fatty Acids)
MANFAAT SUPLEMEN DALAM MENINGKATAN DAYA TAHAN TUBUH SEBAGAI UPAYA PENCEGAHAN COVID-19 Yani, Ketut Tia Pran Anggar; Kurnianta, Putu Dian Marani; Cahyadi, Kadek Duwi; Esati, Ni Ketut; Sawiji, Repining Tiyas; Darmawan, Gede Agus; Pramana, I Gede Komang Aditya; Sujayanti, Luh Gede Tina; Putra, Kadek Ria Dwitya; Purnamasari, I Gusti Ayu Putu Prima
Acta Holistica Pharmaciana Vol 3 No 1 (2021): Acta Holistica Pharmaciana
Publisher : School of Pharmacy Mahaganesha (Sekolah Tinggi Farmasi Mahaganesha)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62857/ahp.v3i1.33

Abstract

Penyakit coronavirus 2019 (COVID-19) yang bermula di Wuhan, Cina pada akhir tahun 2019 telah menyebar pesat sebagai pandemi global hingga ke Indonesia. Tingginya angka kejadian dan dampak mortalitas yang ditimbulkan mendorong dilakukannya berbagai upaya penanganan maupun pencegahan sesuai karakteristik perjalanan penyakit COVID-19. Salah satu upaya pencegahan infeksi maupun perburukan kondisi penderita COVID-19 adalah melalui penggunaan suplemen untuk peningkatan daya tahan tubuh. Diantara berbagai produk suplemen komersil di pasaran, beberapa komponen mikronutrien seperti vitamin B, C, D dan E, seng, dan selenium serta probiotik adalah komponen penting yang memberikan keuntungan dalam mencegah maupun menghadapi infeksi COVID-19. Bukti-bukti ilmiah melalui penelitian telah menunjukkan bahwa masing-masing kandungan suplemen tersebut berperan dalam peningkatan respon imun dan penyeimbang regulasi proses inflamasi dalam tubuh. Dengan demikian, aplikasi penggunaan suplemen adalah upaya rasional untuk menghadapi COVID-19 menuju era new normal, selama suplementasi sesuai dengan kebutuhan masing-masing individu.
Antibacterial activity extract fraction of black garlic against bacteria propionibacterium acnes with disc diffusion method Pandi, Rensiana Kartini; Jawa La, Elisabeth Oriana; Esati, Ni Ketut
Health Sciences and Pharmacy Journal Vol. 6 No. 3 (2022)
Publisher : STIKes Surya Global Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32504/hspj.v6i3.732

Abstract

Black garlic is the result of processing garlic through a heating process at a temperature of 70oC with a relative humidity of 70-80% for 21 days without additional treatment so that the water content decreases. Black garlic has antibacterial activity due to the presence of bioactive compounds from the phenolic and flavonoid groups. This study aims to determine the secondary metabolite content and antibacterial activity of the black garlic extract fraction against Propionibacterium acnes bacteria. Extraction of Black garlic by maceration method used 96% ethanol as solvent and to obtain extract fraction of Black garlic by multilevel fractionation method using n-hexane, ethyl acetate, and ethanol as solvents. To determine the content of secondary metabolites, phytochemical screening was carried out in each fraction. Antibacterial activity test of Propionibacerium acnes used disc diffusion method with various concentrations of n-hexane, ethyl acetate, ethanol fractions 2%, 4%, 6%, 8%, 10%, positive control (clindamycin 1%), negative control and media control. Data analysis was carried out with qualitative, quantitative, and statistical analysis. The results obtained were the extract fraction of black garlic contains secondary metabolites of flavonoids, alkaloids, saponins, and tannins. The results of the antibacterial activity test showed that the garlic extract fraction had antibacterial activity seen from the presence of an inhibition zone. The largest inhibition zone in the n-hexane fraction of 10% concentration of 8.50 ± 0.10 mm was included in the medium category. The positive control was 12.02 ± 1.41 mm and the negative control gave no inhibition zone.
Total Flavonoid Levels in n-hexane and Ethyl Acetate Fractions of Rosmarinus officinalis L. Leaves and Their Antibacterial and Antioxidant Activities Esati, Ni Ketut; La, Elisabeth Oriana Jawa; Sudiasih, Ni Putu; Saniasih, Ni Nyoman Dina
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.4034

Abstract

The rosemary (Rosmarinus officinalis L.) is a plant of the Lamiaceae tribe that has not been widely studied regarding its pharmacological activity, known from previous studies to contain secondary metabolites of flavonoids. Flavonoids are phenol compounds with many pharmacological activities, including antibacterials and antioxidants. This study aims to determine the total flavonoid levels in R. officinalis leaves and their effect on antibacterial and antioxidant activities. This research began with the preparation of ethanol extract from R. officinalis leaves, then the fractionation of the extract produced n-hexane and ethyl acetate fractions. Total flavonoid levels were determined against both fractions by UV-Vis spectrophotometry. A test of the fraction’s antibacterial activity against Staphylococcus aureus was performed using the disc diffusion method. The antioxidant test is carried out by the DPPH method. The total flavonoid content of the ethyl acetate fraction is 47.437 ± 1.947%, higher than the n-hexane fraction. Test antibacterial and antioxidant activity showed more significant results in the ethyl acetate fraction than in the n-hexane fraction. In conclusion, the total flavonoid levels of ethyl acetate fraction are directly proportional to the antibacterial and antioxidant activities of R. officinalis leaves.
IDENTIFIKASI KONTAMINAN TIMBAL DENGAN ELEKTRODA KERJA PASTA KARBON TERMODIFIKASI Esati, Ni Ketut; Cahyadi, Kadek Duwi
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.409

Abstract

This research identified lead (Pb) contaminants in vegetables. The measurement method used was anodic stripping voltammetry (ASV) with a working electrode of carbon paste modified acid-activated natural zeolite. The stages of the research were formulation of the working electrode, validation of the measurement method and measurement of lead levels in vegetables. The result showed that the optimum formulation of working electrode gave the highest measurement peak current. The optimum formulation with composition of graphite: liquid paraffin: acid activates zeolite is 100:35:10. This electrode was used for determination linear range concentration, limit of detection, percent recovery, and repeatability. The measurement of Pb using electrode by ASV method which gave valid results. It can be seen from a wide concentration range from 50-3000 ppb, a low detection limit of 55.28 ppb, good accuracy and precision. The application of this method is to measure Pb levels in vegetables, and the result is 1.43 mg/Kg.
EFEK EKSTRAK ETANOL AKAR CAKAR SETAN (Martynia annua L) TERHADAP AKTIVITAS SGPT DAN SGOT PADA TIKUS YANG DIINDUKSI CCl4 Jawa La, Elisabeth Oriana; Sawiji, Repining Tiyas; Esati, Ni Ketut
Jurnal Ilmiah Manuntung Vol 7 No 1 (2021): Jurnal Ilmiah Manuntung
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i1.414

Abstract

SGPT and SGOT activity from ethanol extract of cakar setan root (Martynia annua L) was investigated. Phytochemical screening was carried out on ethanol extract of cakar setan root (Martynia annua L). The animals were grouped into five groups which consist of 5 rats for each group. The normal/healthy group was only given food and drink the negative control group was given an aqueous suspension of 1 % CMC , the positif control group was given tablets Curcuma at a dose of 200 mg/Kg BB, the group ethanol extract Martynia annua L were each given extract at a dose of 200 mg/Kg BB and 400 mg/Kg BB. All groups were treated for 21 days orally. On day 22 were given injection of CCl4 1.0 mL/kg intraperitoneally except healthy group. The rats blood was taken and analyzed through eye orbitalis sinus AST and ALT activities. The result were statistically analyzed using One Way ANOVA test followed by LSD test. Phytochemical screening ethanolic extract of Martynia annua L root positively contains flavonoids, alkaloids, tannin, phenolic, and terpenoids. The result study that ethanol extract of cakar setan root (Martynia annua L) has hepatoprotective effect of being able to reduce activities of SGPT and SGOT in CCl4 induce white rats.
Penyuluhan Tanaman Kunyit dan Pacar Air Sebagai Alat Deteksi Zat Polutan (Boraks) di Desa Bongkasa-Bali Esati, Ni Ketut
Dharma: Jurnal Pengabdian Masyarakat Vol. 3 No. 2 (2023): Juni
Publisher : LPPPM STAI Darul Hikmah Bangkalan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35309/dharma.v3i2.60

Abstract

The activity of community service in Bongkasa Village, Bali was themed the counseling on turmeric (Curcuma domestica Val.) and water henna plants (Impatiens balsamina L.) as indicator to detecting pollutant substances (borax). The activity targeted young people who were members of Seka Teruna Teruni (STT) Banjar Tanggayuda. This activity was carried out in Bongkasa Village, seeing that the abundance of the plant was very much planted by the villagers. The content of chemical compounds in turmeric rhizome and henna flowers could react with borax to form a colored complex, so that these properties could be used to detect the presence of borax in food. It was known that economic problems caused producers to be irresponsible by adding borax as a food preservative, which is actually prohibited. Borax was a chemical compound derived from the heavy metal boron which generally was used as an antiseptic and bacteria killer, if used as a food additive it could endanger the health of consumers. The activity began with giving the questions to measure the knowledge of the counseling participants, then providing material, demonstrating the manufacture of a borax detector, as well as testing the detector on foods containing borax. Finally, an evaluation of the activity was carried out. The results obtained from this activity that the extension participants were very enthusiastic, this education was expected to add information to the public that there is a simple way to find out if a food contains the dangerous compound borax.
Co-Authors Darmawan, Gede Agus Duwi Cahyadi, Kadek Gusti Ayu Dewi Lestari Jawa La, Elisabeth Oriana Kadek Duwi Cahyadi La, Elisabeth Oriana Jawa Ni Putu Sudiasih, Ni Putu Pandi, Rensiana Kartini Pramana, I Gede Komang Aditya Purnamasari, I Gusti Ayu Putu Prima Putra, Kadek Ria Dwitya Putu Dian Marani Kurnianta Saniasih, Ni Nyoman Dina Sawiji, Repining Tiyas Sujayanti, Luh Gede Tina Yani, Ketut Tia Pran Anggar