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All Journal E-Jurnal Medika Udayana International Journal of Psychology and Health Science Cermin Dunia Kedokteran Folia Medica Indonesiana
Agrasidi, Putu Anindya
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing

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CHARACTERISTICS OF OPEN ANGLE GLAUCOMA PATIENTS AT THE EYE POLYCLINIC PROF DR IGNG NGOERAH GENERAL HOSPITAL DENPASAR 2022 Agrasidi, Putu Anindya; Suryaningrum, I Gusti Ayu Ratna; Kusumadjaja, I Made Agus
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P01

Abstract

Introduction: Open-angle glaucoma is a chronic, progressive, and irreversible multictorial optic neuropathy with open angle of the anterior chamber, accompanied by visual field disturbances, with increased intraocular pressure as the main risk factor, caused by trabecular meshworks resistance. The incidence of open-angle glaucoma is 2.4 million people each year. This study aims to determine the characteristics of open-angle glaucoma patients at the eve polyclinic Prof Dr IGNG Ngoerah Hospital Denpasar in 2022. Methods: This research is a descriptive analytical research with retrospective analysis. The study was conducted by collecting data based on observations of the medical records of patients who visited the Eye Polyclinic at Prof Ngoerah General Hospital in the period of January 1, 2022 until December 31, 2022. A total of 38 people (64 eyes) who met the inclusion and exclusion criteria were analysed using SPSS windows version 26.0. Results: The majority of subjects aged > 60 years (63.2%), male (68.4%). POAG (76.6%), SOAG (23.4%), the most common etiology of SOAG was lens induce, advanced stage (40.6%), and all had chronic onset. The median of visual acuity (logMar) pre operation vs three months post operation 1.0 vs 0.7, IOP 23 mmH vs 16 mmH, the mean of anti glaucoma medication was 1.37 vs 0.6. Conclusion: In patients with open-angle glaucoma, there is a good response to all treatment modalities (medical, trabeculectomy, phacoemulsification-IOL, phacoemulsification- IOL-trabeculectomy, implant glaucoma).
Effect in Pain Scale of Trocar Insertion, Onset, and Duration of Anesthesia of Subtenon Anesthesia without Premedication Compared with Premedication in Pars Plana Vitrectomy: A Randomized Controlled Trial Andayani, Ari; Agrasidi, Putu Anindya; Sutyawan, I Wayan Eka; Widiana, I Gde Raka; Widnyana, I Made Gede; Pemayun, Cok Istri Dewiyani
International Journal of Psychology and Health Science Vol. 3 No. 2 (2025): International Journal of Psychology and Health Science (April - June 2025)
Publisher : Greenation Publisher & Yayasan Global Research National

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/ijphs.v3i2.810

Abstract

Effect in Pain Scale of Trocar Insertion, Onset, and Duration of Anesthesia of Subtenon Anesthesia without Premedication Compared with Premedication in Pars Plana Vitrectomy: A Randomized Controlled Trial. Background: Pars plana vitrectomy (PPV) has traditionally been performed under general anesthesia. However, in recent years, regional anaesthetic techniques such as subtenon block have gained popularity due to their safety and effectiveness, reducing the risk of severe complications associated with needle-based blocks. Patients and Methods: This randomized controlled trial (RCT) was conducted between November 2023 to March 2024 at a tertiary teaching hospital in Indonesia. A total of 30 patients undergoing vitrectomy were randomized assigned to one of two groups: with premedication or without premedication. The primary outcomes evaluated were the pain scale during trocar insertion, the onset of anesthesia, and the duration of anesthesia. Statistical analyses were performed using the Mann-Whitney U test and ANCOVA. Results: No significant differences were observed between the two groups regarding the pain scale during trocar insertion, the onset of anesthesia, or the duration of anesthesia (p<0.001). However, after adjusting for diagnosis and type of the therapy, the group without premedication demonstrated a significantly longer duration of anesthesia. Conclusion: Subtenon anesthesia without premedication represents a viable alternative for pars plana vitrectomy. It offers practical benefits, such as eliminating the need for fasting and intravenous line placement, while maintaining patient and operator comfort.    
Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity Sutyawan, I Wayan Eka; Surasmiati, Ni Made Ayu; Agrasidi, Putu Anindya; Dwianggita, Priscilla; Anggara, Stephanus Anggara
Folia Medica Indonesiana Vol. 59, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: • This is the first systematic review investigating thrombocytopenia and its association with retinopathy of prematurity. • Thrombocytopenia can be a useful clinical biomarker in retinopathy of prematurity screening, considering the quick, affordable, and widespread availability of the examination. Abstract Retinopathy of prematurity (ROP) is the primary cause of childhood blindness. It arises from the underdevelopment of retinal blood vessels in premature infants. Platelets have a vital function in the regulation of angiogenesis. Thus, thrombocytopenia may contribute to the progression of ROP. The objective of this systematic study was to examine the relationship between thrombocytopenia and ROP. The PubMed and Cochrane Library databases were accessed to search for retrospective, case-control, and cross-sectional studies. This study adhered to the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The literature search resulted in nine records to be analyzed in our review. All the selected studies were conducted between 2017 and 2022. Seven studies reported that the prevalence of thrombocytopenia in infants with ROP ranged from 18.37% to 71%. The frequency of thrombocytopenia in preterm children without ROP was between 5.71% and 21%. Thrombocytopenia was identified as a risk factor for ROP in seven studies, with the odds ratio (OR) for thrombocytopenia ranging from 2.8 to 6.69. Thrombocytopenia in premature infants can potentially serve as a clinical biomarker in the screening of type 1 ROP. This finding suggests that thrombocytopenia may contribute to the pathophysiology of ROP. Further research is necessary to determine the critical threshold platelet count for thrombocytopenia in infants with ROP.
Efektivitas Suplementasi Lutein dan Zeaxanthin terhadap Perkembangan Atrofi Geografis dan Ketajaman Penglihatan pada Degenerasi Makula Terkait Usia: Tinjauan Sistematis Berdasarkan Uji Klinis: Tinjauan Sistematik Kesumaputri, Komang Diah Kurnia; Dwipayani, Ni Made; Wibawa, I Made Dwi Surya; Agrasidi, Putu Anindya; -, Felicia
Cermin Dunia Kedokteran Vol 53 No 05 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i05.2155

Abstract

Introduction: Geographic atrophy (GA) is an advanced form of dry age-related macular degeneration (AMD) that can cause severe central vision loss if its progression extends to the foveal area. Currently, therapeutic options for GA remain limited, with safety profiles requiring further evaluation. Lutein and zeaxanthin, as the main components of the Age-Related Eye Disease Study (AREDS2) formula, have become the focus of current research. Both are antioxidants concentrated in the macula, which exert protective effects on retinal structures and reduce oxidative stress. This systematic review aims to evaluate the effectiveness of oral lutein and zeaxanthin supplementation on GA progression and visual acuity in AMD patients. Methods: Literature searches were conducted across four biomedical databases based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. A total of four studies met the inclusion criteria and were analyzed qualitatively. Results: The analysis showed that oral supplementation of lutein (10 mg/day) and zeaxanthin (2 mg/day) may reduce the progression of non-central GA and stabilize or improve visual acuity in patients with AMD. Lutein at doses of 10 mg and 20 mg demonstrated similar effectiveness in improving visual acuity through an increase in macular pigment optical density (MPOD). Conclusion: Based on the findings of this systematic review, oral supplementation with lutein (10 mg/day) and zeaxanthin (2 mg/day), as incorporated in the AREDS2 formulation, appears to slow the progression of non-central GA and preserve foveal integrity (foveal sparing). Further long-term studies are required to confirm the clinical benefits and long-term safety.
Co-Authors -, Felicia Anggara, Stephanus Anggara Ari Andayani Dwianggita, Priscilla I Gde Raka Widiana I Made Gede Widnyana Kesumaputri, Komang Diah Kurnia Kusumadjaja, I Made Agus Ni Made Ayu Surasmiati Ni Made Dwipayani, Ni Made Pemayun, Cok Istri Dewiyani Suryaningrum, I Gusti Ayu Ratna Sutyawan, I Wayan Eka Wibawa, I Made Dwi Surya