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Manuaba, Ida Bagus Tjakra Wibawa
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Faktor-faktor yang Memengaruhi Kualitas Hidup Pasien Kanker Payudara Post Mastektomi di RSUP Sanglah Larasati, Made Syanindita Putri; Setiawan, I Gede Budhi; Wetan, Ni Gusti Ayu Agung Manik Yuniawaty; Manuaba, Ida Bagus Tjakra Wibawa
E-Jurnal Medika Udayana Vol 11 No 10 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i10.P18

Abstract

Background: Breast cancer is a malignancy of breast tissue that starts from the lobules or epithelial glands of the breast, where cancer cells grow out of control. Quality of life is a functional representation of physical, psychological, and social responses. Breast cancer affects a person's quality of life which is influenced by various factors, so it is necessary to conduct further research on the quality of life of post-mastectomy breast cancer patients at Sanglah Hospital to determine the quality of life of post-mastectomy breast cancer patients at Sanglah Hospital. Methods: This research is a cross sectional descriptive analytic study with primary and secondary data collection. The sample collection technique is total sampling with inclusion and exclusion criteria considerations, in order to obtain 92 respondents who then answered the EORTC QLQ-C30 questionnaire which was distributed for 3 months (July-September). The variables measured included quality of life, age, KPS, education level, occupation, stage, therapy, economic condition, and physical activity of breast cancer patients. Results: This study was analyzed by univariate, bivariate, and multivariate. From 92 respondents, the quality of life of breast cancer patients was found to be functional in good condition, symptoms and complaints were in poor condition, and overall quality of life and health were in good condition. In the bivariate analysis, therapy, occupation, physical activity, and KPS affect quality of life. In multivariate analysis, KPS affects the condition of symptoms and complaints, and physical activity affects the condition of quality of life and overall health. Conclusion: The quality of life of post-mastectomy breast cancer patients at Sanglah Hospital is generally in good condition, but there are several factors that affect the quality of life of post-mastectomy breast cancer patients at Sanglah Hospital. Keywords : Breast cancer, quality of life, questionnaire EORTC QLQ-C30
GAMBARAN PASIEN KARSINOMA TIROID BERDIFERENSIASI DI RSUP SANGLAH TAHUN 2015-2020 Wisescistiati, Made Visvayoni; Yuniawaty Wetan, Ni Gusti Ayu Agung Manik; Manuaba, Ida Bagus Tjakra Wibawa; Adiputra, Putu Anda Tusta
E-Jurnal Medika Udayana Vol 11 No 4 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i04.P13

Abstract

ABSTRACT Background: differentiated thyroid carcinoma (DTC) is the most common type found in thyroid malignancies. Onset of the disease is influenced by several factors such as history of radiation exposure, environmental influences and iodine intake in certain areas. Due to the limited data in Indonesia related to the mapping of differentiated thyroid cancer cases, the author is interested in conducting this study. Objective: to determine the description of differentiated thyroid carcinoma patients in Sanglah General Hospital year 2015-2020. Methods: cross-sectional descriptive study. The population and samples were all patients diagnosed with differentiated thyroid cancer treated at the SMF/Surgery Department of Sanglah General Hospital year 2015 -2020. The variables in this study are age, gender, area of residence, main diagnosis, staging and therapy. Results: total sample obtained 223 patients. Most common age group were 41-50 years old with 52 people (23.3%). Women are more common with 173 people (77.6%). Denpasar City has the highest number of cases with 75 people (33.6%). The main diagnosis is papillary thyroid cancer (PTC) with 215 cases (96.4%). Stage I are most found with 140 cases (62.8%). Most widely given therapy is total thyroidectomy in 183 people (82.1%) and 124 people (55.6%) received radio ablation. Conclusion: In this study, differentiated thyroid carcinoma was mostly found in women, at the age of 41-50 years, residents living in Denpasar. Papillary thyroid cancer (PTC) as the most common type in stage I and mostly treated with total thyroidectomy. Keywords : description, differentiated thyroid carcinoma, sociodemographic
Expression of CD8+ and Foxp3+ T Lymphocyte as Predictor for Response to Neoadjuvant Chemotherapy in Stage III Breast Cancer Yasa, I Nyoman Wawan Tirtha; Sudarsa, I Wayan; Niryana, I Wayan; Sriwidyani, Ni Putu; Jawi, I Made; Yasa, I Wayan Putu Sutirta; Manuaba, Ida Bagus Tjakra Wibawa; Suryawisesa, Ida Bagus Made
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3680

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) in breast cancer is usually utilized to eradicate micro-metastasis, induce apoptosis in tumor cells, and reduce the primary tumor size, enabling surgical intervention. Recent studies have shown that tumor-infiltrating lymphocytes (TILs), especially cytotoxic CD8+ T cells and immunosuppressive Foxp3+ regulatory T cells, influence tumor response to treatment. However, their role as predictive markers for NAC response remains unclear. Therefore, this study was performed to investigate whether high expression of CD8+ and low expression of Foxp3+ T lymphocytes are associated with better response to NAC in stage III breast cancer patients.METHODS: Total of 60 biopsy samples from stage III breast cancer patients were included, comprising 30 subjects in the response group (+) and 30 subjects in the non-response group (−). The expression levels of CD8+ and Foxp3+ T lymphocytes in tumor tissue were assessed semi-quantitatively by immunohistochemistry (IHC), using a scoring system based on the proportion and intensity of positively stained cells (Black’s grading criteria).RESULTS: Stage III breast cancer with high expression of CD8+ T lymphocytes was significantly associated with a better response to NAC (p=0.004; OR=6.882). Meanwhile, low expression of Foxp3+ T lymphocytes was not significantly associated with chemotherapy response (p=0.067; OR=3.250). A higher tumor grade was also associated with an improved response to treatment. The probability of achieving a positive response to NAC in subjects presenting with high CD8+ expression, low Foxp3+ expression, and high tumor grade was estimated at 96.98%.CONCLUSION: The combination of high expression of CD8+ T lymphocyte, low expression of Foxp3+ T lymphocyte and high tumor grade might be useful to predict good response to NAC in stage III breast cancer.KEYWORDS: CD8+ T lymphocyte, Foxp3+ T lymphocyte, neoadjuvant chemotherapy, breast cancer
Serum CD44 Variant 6 to CD44 Ratio and Vascular Endothelial Growth Factor Levels as Predictors of Metastasis in Luminal Subtype Breast Cancer Kendarini, Ni Putu Yenny; Manuaba, Ida Bagus Tjakra Wibawa; Sudarsa, I Wayan; Mahadewa, Tjokorda Gde Bagus; Dewi, Ni Nyoman Ayu; Prayuda, Prayuda; Pertiwi, Putu Febry Krisna
The Indonesian Biomedical Journal Vol 17, No 3 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i3.3586

Abstract

BACKGROUND: Metastasis is the leading cause of mortality in luminal subtype breast cancer. While cluster of differentiation (CD)44 has been widely studied, the prognostic relevance of its isoforms particularly the CD44v6/CD44s ratio remains unclear. This study evaluates CD44v6, CD44s, vascular endothelial growth factor (VEGF), and the CD44v6/CD44s ratio as potential prognostic biomarkers for metastasis in luminal breast cancer.METHODS: This case-control study included 38 luminal subtype breast cancer patients (18 with metastasis, 20 without metastasis). Serum levels of CD44v6, CD44s, VEGF, and the CD44v6/CD44s ratio were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Statistical analyses included ROC analysis to determine optimal cut-off points, logistic regression to assess risk factors, and correlation analysis for biomarker relationships.RESULTS: A low CD44v6/CD44s ratio (<0.03) was identified as a significant independent factor for metastasis (adjusted OR 7.0, 95% CI: 1.2–40.6, p=0.03). While serum levels of CD44v6, CD44s, and VEGF were higher in the metastasis group, these individual markers showed a non-significant trend toward association with metastasis. A strong positive correlation was observed between CD44s and VEGF levels (r=0.7, p<0.01).CONCLUSION: The CD44v6/CD44s ratio showed a significant association with metastasis and may have potential as a prognostic marker in luminal breast cancer. Further studies with larger sample sizes are needed to confirm these findings.KEYWORDS: CD44v6, CD44s, VEGF, CD44v6/CD44s ratio, luminal breast cancer, metastasis
Co-Authors I Made Jawi I W. Sudarsa I Wayan Niryana I Wayan Putu Sutirta Yasa Kendarini, Ni Putu Yenny Larasati, Made Syanindita Putri Ni Nyoman Ayu Dewi Ni Putu Sriwidyani Pertiwi, Putu Febry Krisna Prayuda, Prayuda Putu Anda Tusta Adiputra Setiawan, I Gede Budhi Suryawisesa, Ida Bagus Made Tjokorda Gde Bagus Mahadewa Wetan, Ni Gusti Ayu Agung Manik Yuniawaty Wisescistiati, Made Visvayoni Yasa, I Nyoman Wawan Tirtha Yuniawaty Wetan, Ni Gusti Ayu Agung Manik