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All Journal E-Jurnal Medika Udayana Indonesian Journal of Cancer
Wetan, Ni Gusti Ayu Agung Manik Yuniawaty
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Faktor-faktor yang Memengaruhi Kualitas Hidup Pasien Kanker Payudara Post Mastektomi di RSUP Sanglah Larasati, Made Syanindita Putri; Setiawan, I Gede Budhi; Wetan, Ni Gusti Ayu Agung Manik Yuniawaty; Manuaba, Ida Bagus Tjakra Wibawa
E-Jurnal Medika Udayana Vol 11 No 10 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i10.P18

Abstract

Background: Breast cancer is a malignancy of breast tissue that starts from the lobules or epithelial glands of the breast, where cancer cells grow out of control. Quality of life is a functional representation of physical, psychological, and social responses. Breast cancer affects a person's quality of life which is influenced by various factors, so it is necessary to conduct further research on the quality of life of post-mastectomy breast cancer patients at Sanglah Hospital to determine the quality of life of post-mastectomy breast cancer patients at Sanglah Hospital. Methods: This research is a cross sectional descriptive analytic study with primary and secondary data collection. The sample collection technique is total sampling with inclusion and exclusion criteria considerations, in order to obtain 92 respondents who then answered the EORTC QLQ-C30 questionnaire which was distributed for 3 months (July-September). The variables measured included quality of life, age, KPS, education level, occupation, stage, therapy, economic condition, and physical activity of breast cancer patients. Results: This study was analyzed by univariate, bivariate, and multivariate. From 92 respondents, the quality of life of breast cancer patients was found to be functional in good condition, symptoms and complaints were in poor condition, and overall quality of life and health were in good condition. In the bivariate analysis, therapy, occupation, physical activity, and KPS affect quality of life. In multivariate analysis, KPS affects the condition of symptoms and complaints, and physical activity affects the condition of quality of life and overall health. Conclusion: The quality of life of post-mastectomy breast cancer patients at Sanglah Hospital is generally in good condition, but there are several factors that affect the quality of life of post-mastectomy breast cancer patients at Sanglah Hospital. Keywords : Breast cancer, quality of life, questionnaire EORTC QLQ-C30
Karakteristik dan Faktor Risiko Kanker Payudara di Rumah Sakit Umum Pusat Prof. Dr. I G.N.G Ngoerah Tahun 2022 Aqilah, Nadya Zalfa; Wetan, Ni Gusti Ayu Agung Manik Yuniawaty; Setiawan, I Gede Budhi; Adiputra, Putu Anda Tusta
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P06

Abstract

Breast cancer is a disease that has high mortality in women throughout the world. Breast cancer has characteristics and risk factors that influence the incidence of breast cancer. The research method uses a retrospective descriptive study and uses secondary data, namely medical records at the Central General Hospital Prof. Dr. I G.N.G. Ngoerah in 2022. Of the total 551 samples, only 319 samples had complete medical records. The variables studied were age, clinical stage, histopathological type, biopsy grade, subtype, lesion location, menopausal status, age at menarche, age at menopause, family history of cancer, parity, breastfeeding history, history of hormonal therapy, and nutritional status in terms of BMI. The results showed that of the 319 breast cancer patients, 77.4% were ?45 years old, 38.2% were stage IIIB, 86.2% were invasive ductal carcinoma, 56.4% were grade III, 36.4% were luminal B subtype, 41.4% were in the menopausal phase, the average age of menarche was 13 years old, 42% had menopause in the 45-50 year age range, 4.4% had a family history of cancer, 73% were multiparous, 91.5% had a history of breastfeeding, 23.8% had a history of hormonal therapy, and 37.3% had a normal BMI nutritional status. Keywords: Characteristics, Risk Factors, Breast Cancer
High CD90 Expression is A Predictor of Axillary Nodal Metastasis in Breast Carcinoma Sriwidyani, Ni Putu; Dewi, I Gusti Ayu Sri Mahendra; Wetan, Ni Gusti Ayu Agung Manik Yuniawaty
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1085

Abstract

Background: Metastasis is the most common cause of death in breast cancer and nodal metastasis is one of the most important predictive factors for distance metastasis. One of the intrinsic properties of cancer cells is that they resemble stem cells which are capable of self-renewal, resistance to chemotherapy and radiation, and metastasis. CD90 is a stem cell marker found in several malignancies, including breast carcinoma. The objective of this study was to prove that CD90 can predict the occurrence of axillary nodal metastasis in breast carcinoma. Methods: The study design was a case-control study. The subjects of this study were breast cancer patients at Prof. Dr. I. G. N. G. Ngoerah Hospital who underwent mastectomy and axillary lymphadenectomy in the year 2019. CD90 immunohistochemistry was performed and its association with metastasis, along with various clinicopathological markers, was assessed with chi-square and logistic regression tests with a significance level determined at α=0.05. Results: There were 25 cases of breast carcinoma with axillary nodal metastasis and 25 cases without metastasis. There was a significant relationship between high CD90 expression and the occurrence of nodal metastasis (p=0.010). There was no relationship between patient age, histologic grade, histologic subtype, molecular subtype, and T-stage with axillary nodal metastasis. Breast carcinoma patients with high CD90 expression have a 7.25 times higher nodal metastasis risk compared to patients with low CD90 expression. Conclusion: High CD90 expression could predict axillary nodal metastasis in breast carcinoma.
Co-Authors Aqilah, Nadya Zalfa I Gusti Ayu Sri Mahendra Dewi Larasati, Made Syanindita Putri Manuaba, Ida Bagus Tjakra Wibawa Ni Putu Sriwidyani Putu Anda Tusta Adiputra Setiawan, I Gede Budhi