Garuda - Garba Rujukan Digital

Peranan triamnicolone acetate terhadap adhesi intraperitoneal pasca laparotomi Saharui, Andre; Lahunduitan, Ishak; Kalitouw, Ferry
Jurnal Biomedik : JBM Vol 9, No 1 (2017): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.9.1.2017.15378

Abstract: Intraperitoneal adhesion could cause mechanical intestinal obstruction, infertility, lengthened duration of operation, and increased intraoperative risk. To date, there is still no certain method to prevent the occurence of intraperitoneal adhesion. Triamcinolone acetate (TA) is a corticosteroid with long half time. Subjects were 16 Wistar rats (Rattus norvegicus) divided into two groups, the control group and the treatment group. Laparotomy and caecal abration were performed on all rats. The treatment group were given 0.1 mg of TA. All rats were terminated on day-14 and intraperitoneal adhesion was evaluated macroscopically and microscopically. The statistical analysis showed that there was a significant difference in the formation of intraperitoneal adhesion between the two groups macroscopically, but not microscopically. Conclusion: Triamnicolone acetate could diminish the formation of intraperitoneal adhesion.Keywords: intraperitoneal adhesion, triamcinolone acetateAbstrak: Adhesi intraperitoneal dapat menyebabkan obstruksi usus mekanik, infertilitas, memperpanjang waktu operasi, dan meningkatkan risiko terjadinya cidera intraoperatif. Sampai saat ini belum ditemukan metode yang tepat untuk mencegah terjadinya adhesi intraperitoneal. Triamcinolone Acetate (TA) merupakan kortikosteroid dengan waktu paruh yang panjang. Subyek penelitian ialah 16 ekor tikus Wistar (Rattus norvegicus) dibagi dalam 2 kelompok:kelompok kokntrol dan kelompok perlakuan. Dilakukan laparotomi dan abrasi saekum pada semua tikus. Kelompok perlakuan diberikan TA dengan dosis 0,1 mg. Tikus diterminasi pada hari ke-14 dan dinilai derajat adhesi intraperitoneal secara makroskopik dan mikroskopik. Hasil analisis statistik memperlihatkan bahwa pembentukan adhesi intraperitoneal antara kedua kelompok kontrol berbeda bermakna secara makroskopik namun tidak berbeda bermakna secara mikroskopik. Simpulan: Triamnicolone acetate dapat menekan pembentukan adhesi intraperitoneal.Kata kunci: adhesi intraperitoneal, triamcinolone acetate

Hubungan Nilai Carcinoembryonic Antigen dengan Kejadian Metastasis Karsinoma Kolorektal di RSUP Prof. Dr. R. D. Kandou Manado Maradjabessy, Fahrizal; Kalesaran, Laurens; Kalitouw, Ferry; Sapan, Heber
Jurnal Biomedik : JBM Vol 10, No 1 (2018): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.10.1.2018.19002

Abstract: Carcinoembryonic antigen (CEA) is a tumor marker which has been used worldwide as an indicator of recurrency after treatment and prognosis but not for preoperative diagnosis. This study was aimed to obtain the correlation between CEA level and the metastasis of colorectal cancer. This was an analytical correlational study. Population and samples were patients with colorectal cancer that fulfilled the inclusion criteria at Prof. Dr. R. D. Kandou Hospital Manado from January 2015 through December 2016. Data were analyzed with point-biserial correlation coefficient. There were 55 patients with colorectal cancer in this study. The incidence of colorectal cancer was higher in 2016 (37 patients). Most of them were males (63.3%), had colorectal cancer in the rectum (47.3%), and CEA level above normal (98.1%). As many as 36 patients with CEA level above normal had no metastasis. Of 18 patients with metastasis, the most were in liver, followed by lungs and bones. There were 9 patients with CEA level >1000 Î¼g/dl; all had metastasis. The statistical analysis showed a rpb of 0.634 (P < 0.01). The mean level of CEA in patients with metastasis (541.82 Î¼g) was much higher than of them without metastasis (60.19 Î¼g). Conclusion: There was a strong and significant correlation between CEA level and metastasis.Keywords: colorectal cancer, carcinoembryonic antigen (CEA), metastasisAbstrak: Carcinoembryonic antigen (CEA) merupakan salah satu tumor marker yang sudah banyak digunakan secara luas. Saat ini pemeriksaan CEA diangggap berguna untuk indikator faktor rekurensi setelah diterapi dan prognostik, namun kemampuan diagnostik CEA preoperasi masih sangat kurang. Penelitian ini bertujuan untuk mengetahui hubungan antara CEA dengan kejadian metastasis karsinoma kolorektal. Jenis penelitian ialah analitik korelatif. Populasi dan sampel ialah semua pasien karsinoma kolorektal yang memenuhi kriteria inklusi di RSUP Prof. Dr. R. D. Kandou Manado mulai bulan Januari 2015 sampai Desember 2016. Analisis data menggunakan analisis koefisien korelasi point biserial. Hasil penelitian mendapatkan 55 pasien karsinoma kolorektal dengan insiden terbanyak pada tahun 2016 (37 pasien). Terbanyak ditemukan ialah letak karsinoma kolerektal pada daerah rektum (47,3%), jenis kelamin laki-laki (63,3%), dan kadar CEA di atas normal (98,1%). Sebanyak 36 pasien dengan nilai CEA di atas normal tanpa metastasis dan 18 pasien dengan metastasis terbanyak di hati, kemudian paru, dan tulang. Terdapat 9 pasien dengan nilai CEA >1000 Î¼g/dl; kesemuanya mengalami metastasis. Uji statistik mendapatkan rpb = 0,634 dengan P < 0,01. Nilai rerata CEA pada pasien dengan metastasis jauh lebih tinggi (541,82 Î¼g) dibandingkan dengan nilai rerata pada pasien tanpa metastasis (60,19 Î¼g). Simpulan: Terdapat hubungan yang kuat dan bermakna antara CEA dengan metastasis.Kata kunci: karsinoma kolorektal, carcinoembryonic antigen (CEA), metastasis

Besaran Neutrofil dan Kadar C-reactive Protein sebagai Faktor Prognostik Multi Organ Failure pada Pasien Multi-trauma ., Candy; Sapan, Heber B.; Kalesaran, Laurens T. B.; Kalitouw, Ferry
Jurnal Biomedik : JBM Vol 9, No 3 (2017): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.9.3.2017.17341

Abstract: Trauma is the leading cause of death among people under 50 years old worldwide. Severe trauma will trigger systemic inflammatory response syndrome (SIRS) which can worsen into multiple organ failure MOF). This study was aimed to evaluate whether there was a correlation between neutrophil count and C reactive protein concentration in multi-traumatic patients and whether both variables could become predictors of the occurence of MOF. This was a correlation study with a cross sectional design. There were 71 multitraumatic patients enrolled in this study, obtained from Surgery Emergency Unit of Prof. Dr. R. D. Kandou Hospital Manado; 31 of them were associated with SIRS, MODS, and MOF. The regression analysis showed that the higher the neutrophil count was, the greater the chance of the patient to suffer from MOF (P < 0.001), as well as the higher the CRP concentration, the greater the chance of the patient to suffer from MOF (P < 0.001). The cut-off point of neutrophil to MOF was 17121.7 and the specifity was higher than the sensitivity. Morover, the cut-off point of CRP to MOF was 169.7 and the specifity was higher than the sensitivity. Conclusion: There were significant correlations between the neutrophil count and MOF as well as between CRP concentration and MOF. Neutrophil count and CRP concentration could become predictors of the occurence of MOF and were significant in sensitivity and specifity in acute multi-traumatic patients.Keywords: multiple trauma, MOF, neutrophil, CRPAbstrak: Trauma merupakan penyebab kematian nomor satu pada orang berusia kurang dari 50 tahun. Trauma berat akan memicu timbulnya respons inflamasi sistemik berat (Systemic Inflammatory Response Syndrome, SIRS) yang dapat memburuk menjadi kegagalan multi-organ. Penelitian ini bertujuan untuk mengetahui ada tidaknya korelasi antara besaran neutrofil dan kadar CRP pada pasien multi-trauma, dan apakah keduanya dapat digunakan sebagai faktor prediktor dalam mendeteksi terjadinya multi-organ failure (MOF). Jenis penelitian ialah korelasi dengan desain potong lintang. Hasil penelitian mendapatkan 71 pasien multi-trauma yang dirawat di Instalasi Gawat Darurat Bedah RSUP Prof. Dr. R. D. Kandou Manado; 31 di antaranya disertai SIRS, MODS dan MOF. Hasil analisis regresi menyatakan bahwa makin tinggi besaran neutrofil maka makin besar peluang pasien untuk terjadi MOF (P < 0,001), dan makin tinggi CRP maka makin besar peluang pasien untuk terjadi MOF (P < 0,001). Cut-off point neutrofil terhadap MOF ialah 17121,7 dengan nilai spesifisitas lebih besar dari sensitivitas sedangkan cut-off point CRP terhadap MOF ialah 169,7 dengan nilai spesifisitas lebih besar dari sensitivitas. Simpulan: Terdapat hubungan bermakna antara besaran neutrofil dan MOF serta antara CRP dan MOF. Besaran neutrofil dan CRP merupakan prediktor terjadinya MOF yang mempunyai signifikansi dalam sensitivitas dan spesifisitas pada pasien dengan multi- trauma akut.Kata kunci: multi-trauma, MOF, neutrofil, CRP

Primary Closure of Gastric Perforation Using Seromuscular Omentum Insertion: A Case Report Kalitouw, Ferry; Salem, Billy; Sugito, Brian
e-CliniC Vol. 12 No. 2 (2024): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v12i2.46850

Abstract: Gastric perforation is the most common disease and a surgical emergency with high morbidity and mortality; therefore, early and precise management is needed. However, no consensus has been accepted regarding the best surgical treatment for gastric perforation closure so far. Although surgery methods are varied, laparotomy, and omental patch repair are still the gold standard. The risk of leakage after primary closure accompanied by omentopexy is still common, resulting high morbidity and mortality. This study aimed to discuss about the modified method by means of primary closure with seromuscular omentum insertion in a gastric perforation case. We modified the usual method using primary closure with seromuscular omentum insertion, to get the best way for perforation closure and reduced risk of leakage. After a week of surgical perforation closure, the patient was discharged and further observation resulted in no leakage. In conclusion, modified method by using primary closure with seromuscular omentum insertion in gastric perforation has good result without any leakage and recurrence. Keywords: gastric perforation; omentum; primary closure

Profil Kasus Amputasi Jari Traumatik di Rumah Sakit Umum Daerah Bitung Selang 1 Januari 2020 – 30 April 2023 Lintong, Pinkan; Kalitouw, Ferry; Kalitouw, Priscilia
e-CliniC Vol. 13 No. 1 (2025): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v13i1.60578

Abstract: Finger injury is one of the most common types of accidents with varied impacts. The diagnosis of finger amputation is usually based on anamnesis of the history of the mechanism of trauma, the cause of trauma, the extent of contamination in the wound area, and direct clinical physical examination of the amputated finger. This study aimed to obtain the profile of traumatic amputation of finger at Rumah Sakit Umum Daerah Bitung from January 1 to April 30, 2023. This was a descriptive and retrospective study with a cross sectional design. Data were obtained from medical records of patients diagnosed as traumatic amputation of finger from January 1, 2020 to April 30, 2023. The results showed a total of 15 patients consisted of 13 males (87%) and two females (13%). Domestic accident was the most common cause, besides work accidents and traffic accidents. The most common type of trauma is sharp trauma and surgical procedures were performed in the form of stump repair and reamputation due to serious wound contamination and coming to the hospital after more than 24 hours. In conclusion, traumatic amputation of finger is most common among males, aged 10-60 years, sharp trauma, located in digiti II and III, and duration more than 24 hours, therefore, patients have to undergo stump repair, followed by dysartuculation and debridement. Keywords: finger amputation; finger injuries; finger trauma Abstrak: Cedera jari tangan merupakan salah satu jenis kecelakaan yang tersering dengan dampak bervariasi. Diagnosis amputasi jari biasanya didasarkan pada anamnesis riwayat mekanisme terjadinya trauma, penyebab trauma, besarnya kontaminasi pada area luka, serta pemeriksaan fisik klinis secara langsung ke jari yang teramputasi. Penelitian ini bertujuan untuk mendapatkan profil kasus amputasi jari traumatik di Rumah Sakit Umum Daerah Bitung selang 1 Januari 2020–30 April 2023. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Data penelitian diperoleh melalui penelusuran catatan medik penderita yang dirawat dengan diagnosis amputasi jari traumatik selang periode 1 Januari 2020 sampai dengan 30 April 2023. Hasil penelitian mendapatkan sebanyak 15 penderita selama selang waktu tersebut, terdiri dari 13 laki-laki (87%) dan dua perempuan (13%). Kejadian terbanyak didapatkan pada kecelakaan domestik selain kecelakaan kerja dan kecelakaan lalu lintas. Jenis trauma terbanyak ialah trauma tajam dan telah dilakukan tindakan pembedahan berupa stump repair serta reamputasi. Simpulan penelitian ini ialah kasus amputasi jari traumatik yang tersering pada jenis kelamin laki-laki, usia 10-60 tahun, penyebab trauma tajam, lokasi pada digiti II dan III, dengan durasi tindakan lebih dari 24 jam, dan karenanya mengharuskan pasien untuk menjalan prosedur stump repair, diikuti dengan disartikulasi dan debridemen. Kata kunci: amputasi jari; cedera jari; trauma jari

Title

Found 5 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 5 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 5 Documents
Search