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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi Indonesian Journal of Jamu
Indriati, Dwi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Preparation of Single Garlic, Red Ginger, Lemon and Apple Vinegar Combination Tablets By Wet Granulation Method Wiendarlina, Ike Yulia; Fatmi, Mindiya; Indriati, Dwi; Novadin, Raraseta P
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 13, No 2 (2023): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v13i2.9320

Abstract

Garlic, red ginger, lemon, and apple cider vinegar are spices in Indonesia that can be useful for increasing the body's resistance and preventing degenerative diseases. Tablet preparations are preferred because they are practical, easy to use, and easy to carry anywhere. The aim of this research is to see the effect of differences in the concentration of internal and external disintegrants, binders, gliders, and lubricants in each formula. Tablets are made with the single active ingredients of garlic, red ginger, apple cider vinegar, and lemon. The wet granulation method was chosen because natural materials have poor flow properties, so by using the wet granulation method, the flow rate, compressibility, and binding capacity of the granules can be improved for the better so that they can be molded into tablet preparations. The research results showed that all tablet formulas met the tablet evaluation requirements. The concentration of external and internal disintegrants, binders, gliders, and anti-adherents does not make a difference in flow time or angle of repose but provides different water content values in formula 3.There is an influence of differences in the concentration of additional ingredients on the quality of the tablets produced. The greater the concentration, the better the weight uniformity, the harder the resulting tablet, and the longer the disintegration time. Tablet fragility on F2 is high than formula 1 and 3, but still meets tablet quality requirements.
Efek Antidiabetes Fraksi Etil Asetat Ampas Tahu Pada Model Hewan Resisten Insulin Herlina, Nina; Indriati, Dwi; Mulyati; Yulianita; Fitria, Elsa
Jurnal Jamu Indonesia Vol. 5 No. 1 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i1.185

Abstract

Ampas tahu telah menunjukkan efek antidiabetes pada model hewan yang diinduksi aloksan. Penelitian ini bertujuan untuk menguji efek antidiabetes fraksi etil asetat ampas tahu (FEAAT) pada model hewan resisten insulin. Ampas tahu diekstraksi dengan metode refluks menggunakan etanol dan HCl, kemudian difraksinasi menggunakan etil asetat. Mencit dibagi menjadi lima kelompok, yaitu kelompok normal, induksi, obat pembanding (Metformin), FEAAT1 (200 mg/kg bb) dan FEAAT2 (400 mg/kg bb). Mencit diinduksi resisten insulin dengan pemberian diet tinggi lemak dan glukosa selama 14 hari. kemudian diberikan bahan uji selama 14 hari. Pengujian efektivitas antidiabetes dilakukan dengan modifikasi Tes Toleransi Glukosa Oral (TTGO). Nilai Area Under Curve (AUC) diukur sebagai gambaran efek penurunan kadar glukosa darah. Data AUC yang diperoleh dianalisis secara statistik menggunakan uji Analisi of varians (ANOVA) dengan tingkat kepercayaan 95%. Hasil uji menunjukkan bahwa nilai AUC kelompok FEAAT1 tidak memberikan perbedaan yang nyata (p > 0,05) dibandingkan dengan kontrol negatif, sedangkan kelompok FEAAT2 dan Metformin memberikan perbedaan yang nyata (p < 0,05). Jika dibandingkan dengan kelompok normal, kelompok FEAAT2 dan Metformin tidak memiliki pengaruh yang berbeda nyata (p > 0,05) sementara nilai AUC FEAAT1 berbeda nyata (p < 0,05). Dengan demikian dapat disimpulkan bahwa FEAAT2 efektif sebagai antidiabetes pada model hewan resisten insulin.
Co-Authors Fitria, Elsa Ike Yulia Wiendarlina Mindiya Fatmi Mulyati Nina Herlina Novadin, Raraseta P Yulianita