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Ethanol-based solvent system for recovery antioxidant activity Centella asiatica L. Urban and its application in sleep-deprived Rats Wardatun, Sri; Sofihidayati, Trirakhma; Afifah, Nida; Juhroh, Juju
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27277

Antioxidants have the ability to eliminate free radicals by donating electrons to oxidants. Preclinical and clinical studies show that Centella asiatica L. Urban has antioxidant activity. Ethanol was the best solvent for extracted antioxidant compounds from Centella asiatica L. Urban. The concentration of ethanol solvents effect to the compounds extracted and its antioxidant activities. The objective of study to determine ethanol based solvent systems for best recovery of antioxidant activities and in vivo antioxidant activity of the most active extract using stress induced sleep-deprived rats with glutathione (GSH) concentration parameters. Ethanol based solvent system show different recovery antioxidant activity of Centella asiatica L. Urban. Ethanol 70% had the highest recovery of antioxidant activity with an IC50 value of 76.76 ppm. Ethanol 70% Centella asiatica L. Urban extract given in sleep-deprived rats at 300 mg/kg were not significantly different in glutathione levels from those group rats that received the positive control solution (ascorbic acid). The 70% ethanol extract of C. asiatica L. Urban has the potential to ameliorate the stress induced by sleep deprivation.

Pemberdayaan Masyarakat Tentang Penggunaan Antibiotika Melalui Edukasi Gema Cermat Dengan Metode CBIA Di Desa Jambu Luwuk Kabupaten Bogor Setiani, Lusi Agus; Sofihidayati, Trirakhma; Rustiani, Erni
Jurnal Karya Abdi Masyarakat Vol. 4 No. 3 (2020): Jurnal Karya Abdi Masyarakat
Publisher : LPPM Universitas Jambi

Antibiotika merupakan obat yang digunakan untuk mengobati infeksi yang disebabkan oleh bakteri. Perilaku yang salah dalam tata cara penggunaan antibiotika menjadi risiko terjadinya resistensi antibiotik. Gema Cermat atau Gerakan Masyarakat Cerdas Menggunakan Obat merupakan salah satu upaya dalam rangka meningkatkan kesadaran, kepedulian dan pemahaman masyarakat tentang cara penggunaan obat dengan tepat dan benar. Pelaksanaan pengabdian masyarakat dilakukan di Desa Jambu Luwuk Kabupaten Bogor. Metode yang digunakan adalah CBIA, pemberian brosur Gema Cermat, buku saku cara penggunaan obat dan penggolongan obat, pre-test, post-test dan materi melalui presentasi secara oral yang diberikan oleh apoteker. Hasil edukasi dan sosialisasi Gema Cermat, yaitu perbaikan nilai masyarakat mengenai cara penggunaan obat khususnya anibiotika yang benar dan tepat dapat dilihat dari kenaikan nilai rata-rata pre-test 69,0476 menjadi 79,523 pada post-test. Dapat disimpulkan dengan adanya kegiatan ini masyarakat menjadi lebih paham mengenai cara penggunaan obat yang baik dan benar terutama pemakaian antibiotik yang sesuai di masyarakat.

Pemberdayaan Masyarakat Non Produktif Melalui Pelatihan Pemanfaatan Limbah Kulit Pisang Sebagai Minuman Herbal Peningkat Daya Tahan Tubuh Di Desa Jambu Luwuk Kabupaten Bogor Sofihidayati, Trirakhma; Rustiani, Erni; Setiani, Lusi Agus
Jurnal Karya Abdi Masyarakat Vol. 5 No. 3 (2021): Jurnal Karya Abdi Masyarakat
Publisher : LPPM Universitas Jambi

Pada era otonomi daerah yang kini mulai dilaksanakan, sangat diperlukan adanya peningkatan partisipasi masyarakat dalam kegiatan pembangunan dan pemerintahan. Upaya untuk mempercepat terwujudnya kesejahteraan masyarakat daerah sebenarnya telah banyak dilakukan oleh pemerintah. Namun berbagai program tersebut masih dirasa kurang memberikan kesejahteraan pada warga masyarakat di daerah (desa). Desa Jambu Luwuk di Kecamatan Ciawi Kabupaten Bogor memiliki banyak petani dan pedagang buah Pisang. Limbah kulit pisang belum banyak dimanfaatkan di desa Jambu Luwuk. Tim PKM melihat potensi limbah dapat diolah menjadi minuman herbal untuk peningkat daya tahan tubuh. Dengan adanya kondisi wabah pandemi covid-19 ini membuat pemerintah menghimbau masyarakat untuk senantiasa menjaga imunitas/ daya tahan tubuh dengan berbagai cara, salah satunya minuman yang berkhasiat. Tanaman pisang merupakan salah satu tanaman unggulan di Indonesia dan merupakan buah dengan jumlah produksi terbesar. Kulit pisang menjadi bagian yang jarang dimanfaatkan, bagian tersebut dibiarkan atau dibuang sehingga menjadi limbah. Kulit pisang diketahui mengandung senyawa golongan flavonoid seperti naringenin dan rutin yang berperan sebagai antioksidan. Kegiatan PKM diperuntukkan bagi masyarakat non produktif di Desa Jambuluwuk, terutama ibu-ibu rumah tangga dan para pemudi di lingkungan Karang Taruna. Kegiatan dimulai dengan penyuluhan dan pemaparan tentang manfaat serta kandungan kulit pisang. Selanjutnya tim menjelaskan mengenai minuman herbal dengan bahan baku yang diperoleh dari limbah kulit pisang dan aman untuk dikonsumsi terutama untuk meningkatkan daya tahan tubuh masyarakat. Tahap terakhir adalah memberikan pemaparan mengenai pengemasan minuman herbal serta manajemen pemasaran/ keuangan agar produk tersebut dapat dijual dipasaran. Kegiatan ini bertujuan untuk meningkatkan keterampilan mitra sehingga mereka dapat mengembangkan usaha untuk meningkatkan pendapatan sekaligus meningkatkan kesejahteraan masyarakat.

Stunting Prevention Education for Adolescents at Al Falak High School, Bogor City Sofihidayati, Trirakhma; Rustiani, Erni; Wardatun, Sri
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 2 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i2.94

Stunting is a condition where growth disorders occur in children which is characterized by a child's lack of height compared to children his age. Several factors cause stunting, especially in the city of Bogor, including lack of nutritional intake in the first 1000 days of life (HPK), early marriage (39 percent), teenagers suffering from anemia (3.52 percent), pregnant women with anemia (11.8 percent ), and the Covid-19 pandemic factor that occurred during the last two years. Anemia in adolescent girls (rheumatism) has an impact on health and performance at school and can be at risk of anemia when they become pregnant mothers, causing suboptimal growth and development of the fetus, potentially causing complications in pregnancy and childbirth, as well as maternal and child death. The Blood Supplement Tablet (TTD) supplementation program for young women started in 2014 and is one of the efforts to reduce stunting. Stunting has an impact on children's growth and development both physically and cognitively, including affecting the growth and development of toddlers, less than optimal motor skills in children, and affecting learning abilities, thus affecting children's IQ. The intervention activities of the UNPAK Community Service (PKM) team on the problem of stunting were carried out on students in grades 11 and 12 of Al Falak High School, Bogor City by providing education about preventing stunting through nutritious food, anemia, blood supplements tablets (BST) containing iron (Fe)) and distribute health information media regarding stunting. It is hoped that this PKM activity will be able to increase knowledge and awareness of teenagers and expectant mothers regarding stunting.

Stunting Prevention Education for Adolescents at Al Falak High School, Bogor City Sofihidayati, Trirakhma; Rustiani, Erni; Wardatun, Sri
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 2 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i2.94

Stunting is a condition where growth disorders occur in children which is characterized by a child's lack of height compared to children his age. Several factors cause stunting, especially in the city of Bogor, including lack of nutritional intake in the first 1000 days of life (HPK), early marriage (39 percent), teenagers suffering from anemia (3.52 percent), pregnant women with anemia (11.8 percent ), and the Covid-19 pandemic factor that occurred during the last two years. Anemia in adolescent girls (rheumatism) has an impact on health and performance at school and can be at risk of anemia when they become pregnant mothers, causing suboptimal growth and development of the fetus, potentially causing complications in pregnancy and childbirth, as well as maternal and child death. The Blood Supplement Tablet (TTD) supplementation program for young women started in 2014 and is one of the efforts to reduce stunting. Stunting has an impact on children's growth and development both physically and cognitively, including affecting the growth and development of toddlers, less than optimal motor skills in children, and affecting learning abilities, thus affecting children's IQ. The intervention activities of the UNPAK Community Service (PKM) team on the problem of stunting were carried out on students in grades 11 and 12 of Al Falak High School, Bogor City by providing education about preventing stunting through nutritious food, anemia, blood supplements tablets (BST) containing iron (Fe)) and distribute health information media regarding stunting. It is hoped that this PKM activity will be able to increase knowledge and awareness of teenagers and expectant mothers regarding stunting.

Ethanol-based solvent system for recovery antioxidant activity Centella asiatica L. Urban and its application in sleep-deprived Rats Wardatun, Sri; Sofihidayati, Trirakhma; Afifah, Nida; Juhroh, Juju
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27277

Antioxidants have the ability to eliminate free radicals by donating electrons to oxidants. Preclinical and clinical studies show that Centella asiatica L. Urban has antioxidant activity. Ethanol was the best solvent for extracted antioxidant compounds from Centella asiatica L. Urban. The concentration of ethanol solvents effect to the compounds extracted and its antioxidant activities. The objective of study to determine ethanol based solvent systems for best recovery of antioxidant activities and in vivo antioxidant activity of the most active extract using stress induced sleep-deprived rats with glutathione (GSH) concentration parameters. Ethanol based solvent system show different recovery antioxidant activity of Centella asiatica L. Urban. Ethanol 70% had the highest recovery of antioxidant activity with an IC50 value of 76.76 ppm. Ethanol 70% Centella asiatica L. Urban extract given in sleep-deprived rats at 300 mg/kg were not significantly different in glutathione levels from those group rats that received the positive control solution (ascorbic acid). The 70% ethanol extract of C. asiatica L. Urban has the potential to ameliorate the stress induced by sleep deprivation.

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