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All Journal Jurnal Ilmiah Farmasi Pharmacon Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) CHEESA: Chemical Engineering Research Articles Digital Zone: Jurnal Teknologi Informasi dan Komunikasi Journal of Science Innovare Komputasi: Jurnal Ilmiah Ilmu Komputer dan Matematika FITOFARMAKA: Jurnal Ilmiah Farmasi Majalah Farmasetika Jurnal Farmamedika (Pharmamedica Journal) Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Karya Abdi Masyarakat Jurnal Ilmiah Ilmu Terapan Universitas Jambi Kenduri: Jurnal Pengabdian Dan Pemberdayaan Masyarakat
Lusi Agus Setiani
Pharmacy Study Program, Faculty of Mathematics and Science, Universitas Pakuan, Bogor
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health Social Sciences

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PENENTUAN KADAR FLAVONOID EKSTRAK ETANOL 70% KULITBAWANG MERAH (Allium cepa L.) DENGAN METODE MASERASI DAN MAE (Microwave Assisted Extraction) Setiani, Lusi Agus; Sari, Bina Lohita; Indriani, Lusi; Jupersio, Jupersio
FITOFARMAKA | Jurnal Ilmiah Farmasi Vol 7, No 2 (2017): Vol.7, No.2, Desember 2017
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (368.983 KB)

Abstract

ABSTRAKKulit bawang merah mengandung senyawa flavonoid, polifenol, saponin, terpenoid dan alkaloid. Golongan flavonoid yang terdapat pada kulit bawang merah adalah flavonol yang berkhasiat sebagai antioksidan kuat serta diketahui dapat mengurangi risiko tumor, kanker, penyakit jantung, stroke, bronchitis, asma dan anti peradangan. Penelitian ini bertujuan untuk menentukan dan membandingkan kadar flavonoid ekstrak etanol 70% kulit bawang merah  menggunakan metode maserasi dan MAE (Microwave Assited Extraction). Metode ekstraksi maserasi dilakukan pada suhu kamar dan MAE pada suhu 80ºC. Kadar flavonoid diukur menggunakan alat spektrofotometri UV-VIS  dengan  reagen  AlCl3.      Senyawa  standar  flavonoid  yang digunakan adalah kuersetin. Kadar flavonoid yang didapatkan dengan metode maserasi adalah sebesar 14,92% dan kadar flavonoid yang didapatkan dengan metode MAE adalah sebesar 17,18%.   Dari data ini dapat disimpulkan bahwa metode MAE  (Microwave Assited  Extraction)  lebih  efektif digunakan  untuk  mengekstrak  flavonoid  dari kulit bawang merah dibandingkan dengan metode maserasi. Kata Kunci: Kulit bawang merah, maserasi, MAE, flavonoid
Activity of Antioxidant and Inhibitor α-Glucosidase Instant Granul Ethanol Tea Leaf Extract (Camellia sinensis) and Tea Benalu (Scurulla atropurpureea BL Dans) Setiani, Lusi Agus; Sari, Bina Lohita
Journal of Science Innovare Vol 1, No 01 (2018): Journal of Science Innovare
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.824 KB) | DOI: 10.33751/jsi.v1i01.676

Abstract

Tea leaves are plants that are widely spread especially in the area of West Java, while parasites are parasitic plants in tea trees that empirically have various properties such as antioxidants and anti diabetic. The α-glucosidase inhibitor is one of the therapeutic drugs for diabetic that works by inhibiting carbohydrate metabolism. Instant granule preparation is one form of dosage used by dissolving in water. This study aims to determine the antioxidant activity and inhibitors of instant granular α-glucosidase ethanolic extract of Tea and Tea Tea leaves. The extract was obtained from extraction with 60% ethanol solvent-assisted extraction (MAE) method. Research was done by making 3 formula (Formula 1, 2 and 3) with comparison of tea leaf extract, parasite, Polivinil pyrrolidone (PVP) and cyclodextrin ie 26,88%, 1,8%, 2%, 0% (Formula 1) 26.88%, 0%, 3%, 12% and 0% (Formula 2), 1.8%, 4%, 15% (Formula 3). Formula 2 is active as an antioxidant and α-glucosidase enzyme inhibitor with IC50 values of 68.21 and 56.76 ppm. Keywords: Tea Leaves, Benalu Tea, Antioxidants, α-glucosidase Inhibitors, Instant Granules
Uji Aktivitas Antiinflamasi Infusa Daun Afrika (Vernonia amygdalina) pada Tikus Putih yang Diinduksi Karagenan Lusi Agus Setiani; Moerfiah Moerfiah; Yulianita Yulianita
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9322

Abstract

Inflammation is one of the immune system's main responses to infection and irritation. One of the medicinal plants that can be used as anti-inflammatory is African leaves because there have flavonoid compounds. Flavonoid compounds have anti-inflammatory effects that can regulate arachidonic acid metabolism by inhibiting cyclooxygenase (COX) and lipooxygenase activity.This study aims to determine the effectiveness and determine the effective dose of African leaf infusion as anti-inflammatory in sparague dawley strain  induced carrageenan male white rats. The method used is measurement of udema with subplantar 1% carrageenan induction.Test animals used were 20 male rats divided into 5 groups. Each group consisted of 4 rats. Group I as a negative control was given CMC-Na solution, the second group as a positive control was given diclofenac sodium with 1.26 mg/200 gBB body weight, group III, IV and V were given African leaf infusion with three dose ratings namely 100, 150, 200 mg/kgBB bodyweight. The results showed that the infusion of African leaves had Antiinflammatory Activity with dose 200 mg/kg body weight as the most effective dose against inhibition of inflammation.           
Analisis Graph Mining dalam Penentuan Senyawa Dan Tanaman Obat Indonesia Sebagai Antihipertensi Lusi Agus Setiani; Deden Ardiansyah; Asep Saepulrohman; Arief Rachman Hakim; Olandina Cahyani P
Komputasi: Jurnal Ilmiah Ilmu Komputer dan Matematika Vol 19, No 1 (2022): Komputasi: Jurnal Ilmiah Ilmu Komputer dan Matematika
Publisher : Ilmu Komputer, FMIPA, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/komputasi.v19i1.4284

Abstract

Hypertension, also known as high blood pressure, is a degenerative disease whose prevalence tends to increase every year. People in Indonesia generally treat this disease by using a mixture of several types of herbal plants or so-called herbs. This study aims to find out the potential of compounds and plants that have effectiveness as antihypertensives by combining the concept of multicomponent-multi-target with a bioinformatics approach. This study aims to find out the potential of compounds and medicinal plants in Indonesia that have effectiveness as antihypertensives using graph mining analysis. Graph tracing techniques can be applied to search for compounds and plants related to target proteins in a disease. Patikan kebo (Euphorbia factor Ti2, betaAmyrin, alpha-Amyrin), mango (3-Carene, L-Histidine), cayenne pepper (Capsanthin, Capsorubin, Solasonine), papaya (L-Histidine, Sterol, Caffeine), and fenugreek ( L-Histidine) is the best plant that acts as an antihypertensive agent by targeting 4 proteins or about 80% of the total 5 significant proteins in hypertension.
PENGARUH PEMBERIAN PILL CARD TERHADAP KEPATUHAN MINUM OBAT DAN TEKANAN DARAH PASIEN HIPERTENSI DI RS PMI KOTA BOGOR Lusi Agus Setiani; Naufal Muharram Nurdin; Indriyana Adiesta Rakasiwi
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 11, No 1 (2021): FITOFARMAKA | Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v11i1.2436

Abstract

Pill card merupakan salah satu media yang dapat digunakan sebagai kartu pengingat minum obat untuk meningkatkan kepatuhan terutama untuk pasien yang memiliki regimen terapi yang kompleks seperti hipertensi. Penelitian ini bertujuan untuk melihat adanya pengaruh dalam pemberian pill card terhadap tingkat kepatuhan minum obat dan penurunan tekanan darah pada pasien hipertensi untuk mencapai outcome terapi. Tingkat kepatuhan dinilai menggunakan kuesioner MMAS-8 (Morisky Medication Adherence Scale) dan pemeriksaan tekanan darah untuk melihat outcome terapi pasien. Penelitian ini menggunakan metode quasi-eksperimental dengan rancangan Pretest Posttest Control Group Design yang dilakukan secara prospektif. Subjek pada penelitian terbagi menjadi dua kelompok, yaitu kelompok intervensi dengan pemberian pill card dan kelompok kontrol tanpa pemberian pill card dengan masing-masing sampel berjumlah 29 pasien. Hasil Penelitian menunjukkan bahwa pemberian pill card dapat memberikan pengaruh secara signifikan (p0,05) terhadap tingkat kepatuhan minum obat dan tekanan darah.
Evaluasi Penggunaan Analgetik Pasca Bedah Apendisitis di Rawat Inap RSUP Fatmawati Jakarta: Analgetic Use Evaluation of Post Apendicitic Surgery Inpatients of Fatmawati Hospital, Jakarta Agas Kurnia Anugrah; Lusi Agus Setiani; Naufal Muharam Nurdin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.686 KB) | DOI: 10.25026/mpc.v13i1.437

Abstract

Appendicitis is a disease caused by vermimorphic inflammation caused by blockages in the lining of the appendix, so it is necessary to perform surgery to treat the pain caused postoperatively will give a feeling of discomfort and potential complications, therapy given to control the pain that is analgetic administration. The purpose of this study is to know the pattern of analgetic use, evacuate the pattern of analgetic use and know the effectiveness of analgetic use in patients post-surgical appendicitis at RSUP Fatmawati Jakarta Year 2019 with retrospective methods and univariate statstic test to determine the distribution of patient characteristics and distribution of analytical use then wilcoxon statistical test to know the relationship of analytical use to decrease the degree of pain. The results of the study were based on univariate methods of patients suffering from mild pain as much as (60.0%), moderate pain (40.0%) then after administered analgetic patients who do not feel pain (10,5%) mild pain (88.4%) moderate pain (1,1%), then the results of each analgetic wilcoxon test showed, that the administration of a single analgetik influences the decrease in the degree of nnyeri with the results of P-value for Tramadol, Paracetamol, and Ketorolac 0,005.
Analisis Faktor-Faktor yang Mempengaruhi Kepatuhan Penggunaan Obat Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit PMI Kota Bogor: Factor Analysis That Affecting Drug Complience of Type 2 Diabetes Mellitus Patients in PMI Hospital, Bogor Astri Harsono Putri; Lusi Agus Setiani; Naufal Muharram Nurdin
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.981 KB) | DOI: 10.25026/mpc.v13i1.441

Abstract

Type 2 diabetes mellitus is insulin resistance with a relative of insulin secretion disorders. The prevalence of diabetes mellitus in Indonesia in 2000 came in fourth place by 8,4 million population and in 2030 is estimated to have increased by 2,3 million. This study aims to evaluate medication adherence and factors related to adherence in type 2 diabetes mellitus. This study uses descriptive analysis design conducted in February to March 2020 with a total 60 outpatient respondents. Respondent adherence rates were measured using the Morisky Medication Adherence Scale 8 Items (MMAS 8-Items) questionnaire. The significance of the relationship between variables with respondent compliance was measured using Chi-Square. While the dominant factor influencing the respondent?s medication adherence was measured using Binary Logistic Regression. The results of the study prove that the level of adherence of people with type 2 diabetes mellitus outpatient in the Bogor City PMI is in the category of ?moderate adherence?. Bivariate analysis results showed a significant relationship between education (p value 0,041), the amount of non-diabetic drugs (p value 0,035) and the total amount of drugs (p value 0,003) with respondent adherence. The results of multivariate analysis showed that the variable total amount of drugs was the dominant factor affecting the adherence of respondent taking medication (Odds Ratio 8,350).
Effectiveness Of Tajin Water (Rice-Water) As A Coupling Food To Improve Weight Board (Mus Musculus) Lusi Agus Setiani; Moerfiah Moerfiah; Putri Kemala Dewi
Journal of Science Innovare Vol 6, No 1 (2023): Journal of Science Innovare, Volume 06 Number 01 2023
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jsi.v6i1.7747

Abstract

Malnutrition can occur on children of aged 6 to 24 months. During this period, there is generally a change in needs from exclusive breastfeeding to complementary foods and additional food can also be added. Starch water which is a springy white liquid obtained from rice that is cooked with the nutritional content of energy, protein, fat, carbohydrates, calcium, iron, vitamin B1. This study aims to test the effectiveness, determine the best concentration and determine the influence of the length time from using of starch water as an additional complementary food to increase body weight of male mice (Mus musculus) for 21 days by oral treatment. The experiment and method that used in this experiment is was pretest-posttest control group design. Starch water is obtained by means of rice being heated with 1200 mL of water for ± 30 minutes, filtering and extracting is obtained. Starch water concentrations commonly used empirically tested in this study are concentrations of 12.5%; 18.7%; 25%. The 25% concentration is the concentration that has an effective effect on body weight of mice with the results (21.87 ± 4.29) which differ 2.38% from the positive control results (24.25 ± 8.93).
PREDIKSI TOKSISITAS SENYAWA JAMU ANTI-HIPERTENSI DENGAN RESEPTOR ANGIOTENSIN II TIPE 1 (AGTR1) SECARA IN SILICO Rizky Lestari; Lusi Agus Setiani; Usep Suhendar
Majalah Farmasi dan Farmakologi Vol. 27 No. 2 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i2.27045

Abstract

Penggunaan jamu antihipertensi dimasyarakat merupakan salah satu pengobatan hipertensi. Kombinasi tanaman sebagai antihipertensi terdiri dari Imperatae rhizoma, Centella herba, Pyllanthi herba, Orhosiphonis folium, Curcumae rhizoma, dan Apii graviolentis. Jamu diketahui bekerja secara sinergis pada banyak reseptor, salah satunya adalah reseptor AGTR1. Sebagai skrining awal keamanan jamu antihipertensi dilakukan prediksi toksisitas berdasarkan interaksinya pada reseptor. Penelitian ini bertujuan memprediksikan interaksi senyawa jamu antihipertensi terhadap reseptor AGTR1 (PDB ID: 4ZUD) dan memprediksi toksisitas senyawa dengan interaksi terbaik secara in silico. Terdapat 196 senyawa dalam jamu antihipertensi yang akan diskrining menggunakan parameter Lipinski’s Rule of Five (ROF). Autodock 4.2 digunakan untuk memprediksi interaksi 126 senyawa yang memenuhi ROF. Dari hasil penambatan diperoleh 14 senyawa dan diambil 5 senyawa dengan interaksi terbaik untuk diprediksikan toksisitas akut dengan nilai LD50 dan toksisitas kronisnya dengan parameter, karsinogen, mutagen, hepatotoksik, dan nefrotoksik menggunakan tools Ochem, Protox II, dan Toxtree. Berdasarkan hasil penelitian menunjukan senyawa dengan interaksi terbaik adalah  alnustone, hinokinin, nirtetralin,  3-O-cis-p-coumaroylkaempferol, dan hypophyllanthin. Hypophyllanthin memiliki interaksi terbaik dengan  nilai konstanta inhibisinya 3,16 µM, energi bebas Gibbs (∆G) -7,5 kkal/mol, dan berikatan dengan 12 asam amino. Dari kelima senyawa tidak ada yang bersifat hepatotoksik; Senyawa alnustone diprediksi karsinogen mutagen; senyawa alnustone dan 3-O-cis-p-coumaroylkaempferol diprediksi nefrotoksik; serta senyawa hypophyllanthin dan nirtetralin diprediksi toksik dengan nilai LD50 500 mg/kg.
The study of conformity of the pharmaceutical service in Puskesmas Bogor City towards PMK No. 74, 2016 Nhadira Nhestricia; Hero Prasetio Kusworo; Lusi Agus Setiani
Jurnal Ilmiah Farmasi 2023: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2023.art12

Abstract

Background: Improving the quality of pharmaceutical services requires a change in the old product-oriented paradigm (drug-oriented) into a new patient-oriented paradigm (patient-oriented) by executing pharmaceutical care. Improving the quality of pharmaceutical services to people who have direct contact through primary health care as the first-level health facility refers to PMK No. 74 of 2016.Objective: This study aims to determine the description of the implementation of pharmaceutical service standards at the Primary Health care facility in Bogor City for the 2022 period based on PMK No. 74 of 2016.Method: This study used a descriptive approach with an exploratory research type. Retrieval of data using questionnaire instruments and observation checklists The research was conducted for six months, from April to September 2022. The population in this study (24 primary health care and 24 pharmacy installation heads as respondents).Results: Based on the research results, the description of the implementation of pharmaceutical service standards at Bogor City Primary Health Care, based on PMK No. 74 of 2016, for the 2022 period showed that the average value of the questionnaire and observation instruments in the fields of management of pharmaceutical supplies and medical consumables (BMHP), clinical pharmacy services, and pharmaceutical quality control had successive values of 94.87, 85.5, and 100% (very good). The results of the value of the availability of pharmaceutical human resources were 95.83% (very good).Conclusion: The conclusion of the implementation of pharmaceutical services at the Bogor City Primary Health Care is in accordance with the pharmaceutical service standards at the Primary Health Care based on PMK No. 74 of 2016. Intisari Latar belakang: Peningkatan kualitas pelayanan kefarmasian menuntut adanya perubahan paradigma lama yang berorientasi terhadap produk (drug oriented) menjadi paradigma berkembang pada era saat ini yang berorientasi pada pasien (patient oriented) dengan melaksanakan pharmaceutical care. Peningkatan kualitas pelayanan kefarmasian pada masyarakat yang berhubungan langsung melalui puskesmas sebagai fasilitas kesehatan tingkat pertama yang merujuk pada PMK No. 74 Tahun 2016. Tujuan: Penelitian ini bertujuan untuk mengkaji kesesuaian implementasi standar pelayanan kefarmasian di Puskesmas Kota Bogor terhadap PMK No 74 Tahun 2016.Metode: Penelitian ini menggunakan pendekatan deskriptif dengan jenis penelitian eksploratif. Pengambilan data menggunakan instrumen kuisioner dan daftar tilik observasi. Penelitan dilakukan selama 6 bulan sejak April – September 2022. Populasi dalam penelitian ini adalah kepada kepala instalasi farmasi di seluruh Puskesmas Kota Bogor.Hasil: Implementasi standar pelayanan kefarmasian Puskesmas Kota Bogor berdasarkan PMK No. 74 tahun 2016 periode 2022 didapatkan hasil nilai rata-rata instrumen kuesioner dan observasi di bidang Pengelolaan Sediaan Farmasi dan Bahan Medis Habis Pakai (BMHP), pelayanan farmasi klinik serta pengendalian mutu kefarmasian memiliki nilai berturutu-turut sebesar 94,87; 85,5; dan 100% (sangat baik). Hasil nilai ketersediaan SDM kefarmasian sebesar 95,83% (sangat baik). Kesimpulan: Pelayanan kefarmasian di Puskesmas Kota Bogor telah sesuai dengan PMK No. 74 Tahun 2016.Kata kunci: pelayanan farmasi; permenkes; puskesmas
Co-Authors . Yulianita, . Agas Kurnia Anugrah Almasyhuri Almasyhuri Arief Rachman Hakim Asep Saepulrohman Astri Harsono Putri Bina Lohita Sari Cyntia Wulandari Deden Ardiansyah Erni Rustiani Hero Prasetio Kusworo Hidayat, Ahmad Arif Indriani, Lusi Indriyana Adiesta Rakasiwi Jupersio, Jupersio Koniah, Eni Megawati, Neng MOERFIAH . Moerfiah Moerfiah Muhammad Ikramin Muhammad, Diki Naufal Muharam Nurdin Naufal Muharram Nurdin Naufal Muharram Nurdin Nhestricia, Nhadira Nina Herlina Nurlita Oktaviana Zunnita Olandina Cahyani P Putri Kemala Dewi Rahma, Yunita Rizky Lestari Sofihidayati, Trirakhma Usep Suhendar Widya Sopyan, Sonia Wisnu Ananta Kusuma Wulandari, Cyntia Zaldy Rusli Zulkarnaen, Silvia Alviani