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Uji Efektivitas Antiinflamasi Ekstrak Daun Jamblang (Syzygium cumini L.) terhadap Mencit (Mus musculus L.) yang diinduksi Karagenan Zunnita, Oktaviana; Moerfiah, Moerfiah; Auliya, Risa
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 17 No 1 (2024): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v17i1.1574

Inflammation is a protective process against tissue injury caused by infection, trauma, or chemicals. The mechanism of inflammation starts from a stimulus that will cause cell damage, these cells will release several phospholipids, one of which is arachidonic acid. Free arachidonic acid will be activated by cyclooxygenase and lipoxygenase enzymes. This enzyme converts arachidonic acid into an unstable form which is further metabolized to leukotrienes, prostaglandins, prostacyclin, and thromboxane. One of the natural medicines used as an inflammatory treatment is jamblang leaf, because there are flavonoids that can inhibit cyclooxygenase and lipoxygenase enzymes. This study aims to determine the anti-inflammatory effect and the best dose of jamblang leaf extract. The method used was 1% carrageenan induction and a digital plethysmometer to measure the volume of inflammation on the soles of the test animals' feet. The test animals used were 25 mice divided into 5 treatment groups, each group consisting of 5 mice. The treatment group consisted of: negative control of 1% Na-CMC, positive control of Diclofenac Sodium 0.182 mg/20 g BW, dose 1 of jamblang leaf extract 10 mg/20 g BW, dose 2: 15 mg/20 g BW and dose 3: 20 mg/kg 20 g BB. The results showed that all doses of jamblang leaf extract had an anti-inflammatory effect and dose 3 was the best dose that reduced the volume of inflammation.

The Potential Activity of Kecombrang (Etlingera elatior) Leaf, Flower, and Stem Extracts on the Duration of Wound Healing in Mice (Mus musculus) Zunnita, Oktaviana; Moerfiah, .; Apriana, Rinal
FITOFARMAKA: JURNAL ILMIAH FARMASI Vol 14, No 1 (2024): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v14i1.10046

Wound is skin tissue damage due to trauma from a sharp object. Kecombrang flower extract is known to be effective in speeding up the healing of wounds because it contains flavonoids, saponins, tannins and steroids. The leaves and stems also contain these compounds, so this research was conducted to see the difference in the potential activity of the wound healing process of the kecombrang plant on the time of wound healing. Natural ingredient extracts are wound healing agents that can fight infection and speed up wound healing. This study used 5 treatment groups consisting of control (-) distilled water, control (+) Povidone Iodine 10 %, leaf extract 10 %, flower extract 10 %, and stem extract 10 %. The parameters observed were the length of the wound and the condition of the wound until the wound healed. The obtained data were analyzed statistically using ANOVA for complately randomized factorial designed. The results of the research show that extracts of kecombrang leaves, flowers, and stems have activity in accelerating the healing process of cut wounds and produce different effects on healing time. Wound healing time for leaf extract is 12 days, flower extract and stem extract is 10 days. The conclusion of this study shows that there is a very real difference in wound healing from treatment with the best treatment for wound healing is the flower extract with highest healing score of 6.42.

POTENSI ANTIPLATELET CAMPURAN EKSTRAK BINAHONG, JAHE DAN KUNYIT PADA MENCIT PUTIH JANTAN Indriani, Lusi; Moerfiah, Moerfiah; Zunnita, Oktaviana; Pradana, Faisal
Jurnal Ilmiah Manuntung Vol 7 No 2 (2021): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v7i2.509

Antiplatelets can inhibit platelets aggregation and have been used in prevention and treatment the trombotic desease. Binahong leaves, ginger dan turmeric have antiplatelets activity. The mixture of these plants are expected to increase the antiplatelets potency. This study aimed to determine the optimum dose of ethanol extracts of binahong leaves, ginger dan turmeric as antiplatelets agent. The antiplatelets testing were carried out by in vivo method using parameter of bleeding and coagulation time. The testing solutions were administered orally once a day for 8 days. There were 7 treatment groups consist of positive control (Acetosal 0.29mg/20gBW), negative control (CMC-Na 0.5%), binahong 10mg/20gBW, mixture 1 of binahong:ginger:turmeric (5:0.5:1mg/20gBW), mixture 2 (10:0.5:1mg/20gBW), mixture 3 (5:1:1mg/20gBW), and mixture 4 (5:0.5:2mg/20gBW). The bleeding and coagulation time were determined at 0, 3rd, 6th and 9th day. The bleeding time was determined by injuring mice tail, the blood that comes out were absorbed with absorption paper. From the first bleeding time until stopped was calculated as bleeding time. The coagulation time was determined by observing the formation of fibrin thread in the broken capillary pipe. The blood from the end tail were absorbed with capillary pipe, and then was broken every 15 seconds. The antiplatelets activity in mice with bleeding time parameter showed that mixture 3 was more effective at 3rd day with an increased of 16.60%, than the positive control group (3.92%). The coagulation time parameter showed that the binahong group was more effective at 9th day with an increased of 203.55%, than the positive control group (89.71%). The mixture of binahong, ginger, and turmeric were the most effective in increasing bleeding time, whereas binahong was the most effective in increasing coagulation time.

EVALUASI PENYIMPANAN DAN PENDISTRIBUSIAN OBAT DI GUDANG APOTEK KIMIA FARMA NOMOR 50 MERDEKA BOGOR JAWA BARAT Honifa, Honifa; Zunnita, Oktaviana; Almasyhuri, Almasyhuri; Inggriani , Amerlia
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.44689

Pelayanan kefarmasian terdiri dari dua bagian utama, yaitu pengelolaan sediaan farmasi seperti alat kesehatan dan Bahan Medis Habis Pakai (BMHP), serta pelayanan farmasi klinik. Pengelolaan sediaan farmasi meliputi berbagai kegiatan penting, seperti perencanaan kebutuhan, pengadaan obat, penyimpanan, distribusi, pemusnahan dan penarikan obat, pengendalian mutu, serta pencatatan dan pelaporan. Penelitian ini bertujuan untuk menganalisis ketepatan cara penyimpanan dan pendistribusian obat di Gudang Apotek Kimia Farma Merdeka Bogor, sekaligus mengkaji faktor-faktor yang mempengaruhi proses penyimpanan dan alur distribusi obat dari gudang hingga ke apotek cabang. Untuk memperoleh data, digunakan metode observasi langsung serta wawancara dengan tenaga teknis kefarmasian dan apoteker yang bekerja di bagian gudang. Data sekunder bersumber dari dokumen gudang, seperti kartu stok, buku masuk dan keluar obat, serta hasil pengamatan kondisi penyimpanan dan suhu di gudang apotek. Analisis dilakukan menggunakan metode deskriptif dengan mengolah data hasil observasi dan wawancara tersebut. Hasil penelitian menunjukkan bahwa ketepatan penyimpanan di gudang apotek dan pelaksanaan distribusi obat masuk dalam kategori sangat baik. Faktor-faktor yang mempengaruhi penyimpanan meliputi pengelompokan obat berdasarkan kelas terapi, urutan alfabetis, bentuk sediaan, serta pengelolaan khusus untuk narkotika dan psikotropika. Alur distribusi ke apotek cabang dilakukan saat tenaga teknis kefarmasian outlet mengajukan permintaan, kemudian gudang menyiapkan obat sesuai pesanan. Distribusi obat dilakukan dengan mengutamakan kesesuaian jumlah fisik dan dokumen, mencantumkan tanggal pengiriman, tanda tangan penerima, nomor batch, dan tanggal kadaluwarsa. Kesimpulan Ketepatan cara penyimpanan obat yang dilaksanakan di gudang Apotek Kimia Farma Merdeka sebesar 90% dan pelaksanaan distribusi oleh gudang Apotek Kimia Farma Merdeka memberikan nilai persentase sebesar 100%.

Socialization and Education on the Utilization of Vitamins in the Bogor Court Public Elementary School Environment Zunnita, Oktaviana; Herlina , Eka; Jakaria, Muhamad; Kurniasari , Devi
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 1 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i1.65

Vitamins are complex compounds that are needed in small amounts by the body. Vitamins function to help regulate or process body activities. without vitamins the body will experience health problems. Considering the great benefits of vitamins, the Indonesian Ministry of Health issued '10 Balanced Nutrition Guidelines' through the Healthy Living Community Movement (GERMAS). By implementing these guidelines, it is hoped that the community, especially school-age children, will have a stronger immune system, in order to avoid a number of diseases. Vitamin A is always given in February and August at an early age. Vitamin A/retinol is involved in the formation, production, and growth of red blood cells, and lymphocyte cells During the pandemic, for the prevention and cure of diseases caused by the covid 19 virus, vitamins C, D and E have a role in therapeutic management. Therefore, it is necessary to introduce the benefits of vitamins starting at elementary school age, by providing socialization and education to parents, teachers and school committees. Socialization and education of the benefits of vitamins in the environment of SD Negri Pengadilan Bogor, conducted online, as well as visits to Pakuan Farma Pharmacy. Parents, teachers and school committee were given education about giving vitamins according to the daily dose, types of water and fat soluble vitamins, in the form of materials and leaflets. In addition, the material provided is about how to dispose of unused vitamins and the vitamin content contained in fruits and vegetables. The results of the PKM showed an increase in knowledge about the benefits of vitamins. It can be concluded that adequate consumption of vitamins and diverse foods with balanced nutrition can increase the potential for achievement in oneself which plays an important role in child development, namely smart, creative, outgoing, independent and confident.

Improving Access to Patient Services at Pharmaceutical Health Services Unit through Health Service Promotion Programs Wulandari, Cyntia; Zunnita, Oktaviana; Setiani, Lusi Agus
Jurnal Pengabdian Masyarakat Inovatif Vol. 2 No. 1 (2024): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v2i1.103

Health promotion is the dissemination of health messages or a form of health education and improving health for the community. Health promotion activities, one of which is free health services to the community, can increase people's enthusiasm to come to health facilities. The purpose of this activity is to increase access to health services from Universitas Pakuan human resources to Pakuan Farma Pharmacy. Activities are carried out with the basic health check method of degenerative diseases recording the results of examinations and providing education and referrals for health therapies and ways of recommending healthy living. Promotion of health service facilities Pakuan Farma Pharmacy with the distribution of pharmacy brochures and multivitamins and activity participants can also get a free consultation from doctor Ghrena from the Health Unit of Faculty in Universitas Pakuan to get therapy and the use of appropriate drugs and drugs on prescriptions can be obtained from Pakuan Farma Pharmacy. The number of participants who participated in the activity was 91 participants with the average results of checking blood sugar levels 115 mg / dL, Cholesterol 189.67 mg / dL, Uric Acid (Men) 5.8 mg / dL, Uric Acid (Women) 5.8 mg / dL, Blood Pressure 136 / 84 mmHg and Average Body Weight 65 Kg. The average results of health checks show that the health service program has had a positive impact on knowing health conditions or first screening for Universitas Pakuan human resources who participated in this activity. Although most parameters are within normal ranges, continued efforts need to be made to prevent and manage certain health risk factors, especially in blood pressure. With a deep understanding of this condition, it is hoped that health service programs can continue to be improved to support the overall welfare of Universitas Pakuan human resources.

Socialization and Education on the Utilization of Vitamins in the Bogor Court Public Elementary School Environment Zunnita, Oktaviana; Herlina , Eka; Jakaria, Muhamad; Kurniasari , Devi
Jurnal Pengabdian Masyarakat Inovatif Vol. 1 No. 1 (2023): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v1i1.65

Vitamins are complex compounds that are needed in small amounts by the body. Vitamins function to help regulate or process body activities. without vitamins the body will experience health problems. Considering the great benefits of vitamins, the Indonesian Ministry of Health issued '10 Balanced Nutrition Guidelines' through the Healthy Living Community Movement (GERMAS). By implementing these guidelines, it is hoped that the community, especially school-age children, will have a stronger immune system, in order to avoid a number of diseases. Vitamin A is always given in February and August at an early age. Vitamin A/retinol is involved in the formation, production, and growth of red blood cells, and lymphocyte cells During the pandemic, for the prevention and cure of diseases caused by the covid 19 virus, vitamins C, D and E have a role in therapeutic management. Therefore, it is necessary to introduce the benefits of vitamins starting at elementary school age, by providing socialization and education to parents, teachers and school committees. Socialization and education of the benefits of vitamins in the environment of SD Negri Pengadilan Bogor, conducted online, as well as visits to Pakuan Farma Pharmacy. Parents, teachers and school committee were given education about giving vitamins according to the daily dose, types of water and fat soluble vitamins, in the form of materials and leaflets. In addition, the material provided is about how to dispose of unused vitamins and the vitamin content contained in fruits and vegetables. The results of the PKM showed an increase in knowledge about the benefits of vitamins. It can be concluded that adequate consumption of vitamins and diverse foods with balanced nutrition can increase the potential for achievement in oneself which plays an important role in child development, namely smart, creative, outgoing, independent and confident.

Improving Access to Patient Services at Pharmaceutical Health Services Unit through Health Service Promotion Programs Wulandari, Cyntia; Zunnita, Oktaviana; Setiani, Lusi Agus
Jurnal Pengabdian Masyarakat Inovatif Vol. 2 No. 1 (2024): JPMI (Jurnal Pengabdian Masyarakat Inovatif)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jpmi.v2i1.103

Health promotion is the dissemination of health messages or a form of health education and improving health for the community. Health promotion activities, one of which is free health services to the community, can increase people's enthusiasm to come to health facilities. The purpose of this activity is to increase access to health services from Universitas Pakuan human resources to Pakuan Farma Pharmacy. Activities are carried out with the basic health check method of degenerative diseases recording the results of examinations and providing education and referrals for health therapies and ways of recommending healthy living. Promotion of health service facilities Pakuan Farma Pharmacy with the distribution of pharmacy brochures and multivitamins and activity participants can also get a free consultation from doctor Ghrena from the Health Unit of Faculty in Universitas Pakuan to get therapy and the use of appropriate drugs and drugs on prescriptions can be obtained from Pakuan Farma Pharmacy. The number of participants who participated in the activity was 91 participants with the average results of checking blood sugar levels 115 mg / dL, Cholesterol 189.67 mg / dL, Uric Acid (Men) 5.8 mg / dL, Uric Acid (Women) 5.8 mg / dL, Blood Pressure 136 / 84 mmHg and Average Body Weight 65 Kg. The average results of health checks show that the health service program has had a positive impact on knowing health conditions or first screening for Universitas Pakuan human resources who participated in this activity. Although most parameters are within normal ranges, continued efforts need to be made to prevent and manage certain health risk factors, especially in blood pressure. With a deep understanding of this condition, it is hoped that health service programs can continue to be improved to support the overall welfare of Universitas Pakuan human resources.

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