Article Per Year (5 Year)
p-Index From 2021 - 2026
0.888
P-Index
This Author published in this journals
All Journal The Indonesian Biomedical Journal The New Ropanasuri Journal of Surgery Abdimasku : Jurnal Pengabdian Masyarakat Jurnal Pengabdian UNDIKMA
Maulanisa, Sinta C.
Department Of Surgical Oncology, Arifin Achmad General Hospital, Faculty Of Medicine, Universitas Riau, Jl. Diponegoro 1, Pekanbaru
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Nursing Public Health Social Sciences Other

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Hepatic Reperfusion Injury following Remote Ischemia: Experimental Study on Oryctolagus cuniculus Maulanisa, Sinta C.; Moenadjat, Yefta; Kekalih, Aria
The New Ropanasuri Journal of Surgery Vol. 3, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. Ischemia/reperfusion (I/RI) injury following limb ischemia is realized to be responsible for remote organs injury which is found in vary, commence with mild injury to a severe one. Nevertheless, liver is an organ susceptible to such an injury. There were studies on I/RI, where ischemia in those studies were induced by direct ligation of hepatic vessels. However, study of remote ischemia was infrequently found. Thus, we run a study aimed to find out hepatic injury following ischemia induced by ligation of an artery with a significant anatomical distance. Method. An experimental study was conducted on New Zealand white rabbit. Ischemia was induced by ligation of right common femoral artery under anesthesia. Ligation was maintained for four hours period. Afterwards, ligation was released, and rabbit was set free in the cage for eight hours period. Laparotomy was carried out to take liver specimens of three different area, namely central, midzonal, and peripheral. These specimens were subjected to study histopathology and biochemical examination for malondialdehyde as well as HIF–1α. In addition, liver function test was carried out for serum bilirubin and transaminases. Results. The study on histomorphologyshowed hepatic injury of central, midzonal and peripheral of the ischemic/reperfusion injury group, which was mostly sinusoidal dilatation. There was a significant statistical different of the three hepatics–zones (central, p = 0.028, midzonal, p = 0.012, and peripheral, p = 0.030). MDA levels showed a significant increase in the ischemic/reperfusion group (p = 0.012, sig α <0.05). Tissue HIF–1α level increased denoted tissue hypoxia in the treatment group. Liver function test showed no abnormality. Conclusion. Oxidative stress and sinusoidal changes were found in three zones, i.e. central, midzonal and peripheral following ischemic of a significant anatomical distance.
Total and Intratumoral CD8+ T Cell Expressions are Correlated with Miller Payne Grading and WHO Clinical Response of Neoadjuvant Chemotherapy Sonar Soni Panigoro; Sinta Chaira Maulanisa; Ahmad Kurnia; Denni Joko Purwanto; Primariadewi Rustamadji; Herqutanto Herqutanto; Ferry Sandra
The Indonesian Biomedical Journal Vol 15, No 2 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i2.2110

Abstract

BACKGROUND: Chemotherapy has reported to stimulate immune system through direct activation of cluster of differentiation (CD)8+ T cells. Neoadjuvant chemotherapy (NAC) is known to improve the clinical response of locally advanced breast cancer (LABC) patients. However, the immune response-related factor evaluation of NAC in LABC patients has not been routinely performed. Therefore, current study was conducted to evaluate the correlation of NAC-induced CD8+ T cell with chemotherapy response based on Miller Payne grading and World Health Organization (WHO) criteria.METHODS: LABC patients were recruited and data regarding age, gender, tumor, nodal stages, histopathological grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki67 were obtained. Biopsy and mastectomy tissues were collected and processed for hematoxylin-eosin and CD8 immunohistochemical staining. CD8+ T cell expression in peritumoral and intratumoral areas were documented and measured. Clinical responses based on Miller Payne grading and WHO were analyzed and correlated with CD8+ T cell expression.RESULTS: There were more subjects with high expression of total (80%), intratumoral (82.5%) and peritumoral (65%) CD8+ T cell expressions. The total (p=0.013) and intratumoral (p=0.015) CD8+ T cell expression, but not peritumoral CD8+ T cell expression, were significantly correlated with Miller Payne Grading. The total (p=0.009) and intratumoral (p=0.001) CD8+ T cell expressions were also significantly correlated with WHO clinical response.CONCLUSION: Total and intratumoral CD8+ T cell expressions are correlated with Miller Payne grading and WHO clinical response of NAC. Therefore, total and intratumoral CD8+ T cell expressions could be suggested as a predictive marker for clinical response of NAC.KEYWORDS: breast cancer, neoadjuvant chemotherapy, CD8, clinical response, Miller Payne, intratumoral, peritumoral 
Optimalisasi Kesehatan Petani Sawit: Pelatihan Pencegahan Efek Neurobehavior dari Pajanan Toksik Organofosfat di Desa Pulau Lawas, Kabupaten Kampar Ulfah, Ulfah; Rangkuti, Ina Farida; Maulanisa, Sinta Chaira; Fitranda, Mulya; Syaputra, Widi
ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT Vol 8, No 1 (2025): JANUARI 2025
Publisher : LPPM UNIVERSITAS DIAN NUSWANTORO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62411/ja.v8i1.2714

Abstract

Indonesia sebagai negara agraris dengan lebih dari 35 juta petani, menghadapi tantangan terkait pengunaan pestisida, khususnya organofosfat, yang dapat mengganggu fungsi saraf dan menyebabkan efek neurobehavior merugikan. Di Desa Pulau Lawas, Kabupaten Kampar, petani sawit, yang merupakan sumber utama ekonomi lokal, terpapar risiko toksik dari pestisida tersebut tanpa pemahaman yang memadai tentang penggunaan yang aman. Oleh karena itu, program pelatihan untuk meningkatkan pengetahuan dan keterampilan petani dalam pencegahan efek neurobehavior dari pestisida organofosfat sangat penting. Kegiatan ini bertujuan untuk meningkatkan kesadaran petani sawit tentang risiko dan dampak dari pajanan toksik organofosfat serta memberikan keterampilan dan pengetahuan untuk mencegah efek neurobehavior yang merugikan. Hasil kajian ini adalah peningkatan pengetahuan petani tentang pestisida khususnya organofosfat, bahaya dan pencegahan pajanan toksik organofosfat. Pengetahuan petani diukur berdasarkan manajemen pendidikan kesehatan yakni pencegahan (preventif), pengetahuan/peningkatan kesehatan (promotif) dan pertolongan pertama keracunan organofosfat (kuratif), masing-masing didapatkan 63%, 58%, dan 75%.
Differential Effects of Anthracycline-based Neoadjuvant Chemotherapy on Stromal and Intratumoral FOXP3+ Tumor-Infiltrating Lymphocytes in Invasive Breast Cancer of No Special Type Rustamadji, Primariadewi; Wiyarta, Elvan; Pramono, Meike; Maulanisa, Sinta Chaira
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2828

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) plays a crucial role in the management of invasive breast cancer with no special type (IBC-NST), with the immune system's response to cancer heavily relying on the dynamics between tumor-infiltrating lymphocytes (TILs) and cancer cells. In this study, the differential effects of anthracycline-based NAC on stromal and intratumoral foxhead box P3 (FOXP3+) TILs expressions were specifically examined.METHODS: In this cross-sectional study, 32 IBC-NST samples were evaluated for pre- and post-NAC FOXP3+ TIL expression as well as the changes of FOXP3+ TIL expression. Comprehensive data collection regarding subjects' age, tumor size, grade, lymphovascular invasion, regional lymph node metastasis, and receptor status were conducted. Immunohistochemistry was utilized to quantify FOXP3+ TILs. The stromal, intratumoral and total FOXP3+ TILs expression were then analyzed.RESULTS: Significant reductions in FOXP3+ TIL expression post-NAC were observed, with stromal FOXP3+ TILs showing a median decrease of 3.6 units in subjetcs aged ≥50 years (p=0.013) and a median decrease of 13.2 units in subjects with tumors ≥5 cm after NAC (p=0.006). In contrast, intratumoral FOXP3+ TILs remained relatively stable, with minor changes. The total FOXP3+ TIL expression, combining stromal and intratumoral components, was significantly decreased with a median of 13.0 units decreased to 5.3 units (p<0.001).CONCLUSION: This study highlights the significant reduction in stromal FOXP3+ TIL expression after NAC treatment in IBC-NST subjects, in contrast to the relatively stable intratumoral FOXP3+ TILs. Understanding these differences may guide future therapeutic strategies and improve treatment outcomes for IBC-NST.KEYWORDS: biomarkers, chemotherapy, FOXP3, prognostic, response, lymphocyte 
Community-Based Tele-Mentored Ultrasound for Urological Screening in Rural Primary Care Afdal; Jaya, Indra; Hardiansyah, Muhammad Teguh; Yashar, Muhammad Adan; Prihartomo, Gatot Aji; Deviandri, Romy; Maulanisa, Sinta Chaira
Jurnal Pengabdian UNDIKMA Vol. 7 No. 2 (2026): May
Publisher : LPPM Universitas Pendidikan Mandalika (UNDIKMA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/jpu.v7i2.20028

Abstract

This community service activity aims to assess the feasibility and impact of the community-based HHUS tele-mentoring program for urological screening in rural primary healthcare centers in Indonesia. A prospective quasi-experimental study was conducted from August to October 2025 at Pangkalan Baru Primary Health Center, Riau, Indonesia. Four general practitioners (GPs) underwent a one-day HHUS training session, followed by one month of tele-mentoring using the UroSono Mentor app, a telemedicine platform that supports both real-time video consultation and asynchronous image review, and one additional month of independent practice. Confidence, usability, feasibility, mentor responsiveness, patient satisfaction, and behavioral intention were assessed using structured questionnaires. Data were analyzed using the Friedman test (p < 0.05). Confidence scores improved significantly across all phases (p = 0.018), increasing from 2.06 (pre-training) to 4.37 (tele-mentoring) and 3.81 (independent practice). Training satisfaction was high (3.81 ± 0.19), with positive ratings for mentor responsiveness (4.44 ± 0.24) and usability (4.13 ± 0.14). Patient satisfaction averaged 4.49 ± 0.54. Of the 26 patients examined, 69.2% had normal findings, while 30.8% required referral. Community-based tele-mentored HHUS effectively enhanced GPs’ competence and confidence, achieving strong acceptance among both healthcare providers and patients. The UroSono Mentor model shows promise for scalable integration into rural urological screening programs.
Co-Authors Afdal Ahmad Kurnia Aria Kekalih Denni Joko Purwanto Deviandri, Romy Ferry Sandra Hardiansyah, Muhammad Teguh Herqutanto Herqutanto Indra Jaya Mulya Fitranda Pramono, Meike Prihartomo, Gatot Aji Primariadewi Rustamadji Primariadewi Rustamadji Rangkuti, Ina Farida Sonar Soni Panigoro Syaputra, Widi Ulfah Ulfah Wiyarta, Elvan Yashar, Muhammad Adan Yefta Moenadjat