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All Journal The Indonesian Biomedical Journal Jurnal Ners The New Ropanasuri Journal of Surgery Abdimasku : Jurnal Pengabdian Masyarakat
Maulanisa, Sinta C.
Department Of Surgical Oncology, Arifin Achmad General Hospital, Faculty Of Medicine, Universitas Riau, Jl. Diponegoro 1, Pekanbaru
Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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Hepatic Reperfusion Injury following Remote Ischemia: Experimental Study on Oryctolagus cuniculus Maulanisa, Sinta C.; Moenadjat, Yefta; Kekalih, Aria
The New Ropanasuri Journal of Surgery
Publisher : UI Scholars Hub

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Abstract

Introduction. Ischemia/reperfusion (I/RI) injury following limb ischemia is realized to be responsible for remote organs injury which is found in vary, commence with mild injury to a severe one. Nevertheless, liver is an organ susceptible to such an injury. There were studies on I/RI, where ischemia in those studies were induced by direct ligation of hepatic vessels. However, study of remote ischemia was infrequently found. Thus, we run a study aimed to find out hepatic injury following ischemia induced by ligation of an artery with a significant anatomical distance. Method. An experimental study was conducted on New Zealand white rabbit. Ischemia was induced by ligation of right common femoral artery under anesthesia. Ligation was maintained for four hours period. Afterwards, ligation was released, and rabbit was set free in the cage for eight hours period. Laparotomy was carried out to take liver specimens of three different area, namely central, midzonal, and peripheral. These specimens were subjected to study histopathology and biochemical examination for malondialdehyde as well as HIF–1α. In addition, liver function test was carried out for serum bilirubin and transaminases. Results. The study on histomorphologyshowed hepatic injury of central, midzonal and peripheral of the ischemic/reperfusion injury group, which was mostly sinusoidal dilatation. There was a significant statistical different of the three hepatics–zones (central, p = 0.028, midzonal, p = 0.012, and peripheral, p = 0.030). MDA levels showed a significant increase in the ischemic/reperfusion group (p = 0.012, sig α <0.05). Tissue HIF–1α level increased denoted tissue hypoxia in the treatment group. Liver function test showed no abnormality. Conclusion. Oxidative stress and sinusoidal changes were found in three zones, i.e. central, midzonal and peripheral following ischemic of a significant anatomical distance.
Total and Intratumoral CD8+ T Cell Expressions are Correlated with Miller Payne Grading and WHO Clinical Response of Neoadjuvant Chemotherapy Sonar Soni Panigoro; Sinta Chaira Maulanisa; Ahmad Kurnia; Denni Joko Purwanto; Primariadewi Rustamadji; Herqutanto Herqutanto; Ferry Sandra
The Indonesian Biomedical Journal Vol 15, No 2 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i2.2110

Abstract

BACKGROUND: Chemotherapy has reported to stimulate immune system through direct activation of cluster of differentiation (CD)8+ T cells. Neoadjuvant chemotherapy (NAC) is known to improve the clinical response of locally advanced breast cancer (LABC) patients. However, the immune response-related factor evaluation of NAC in LABC patients has not been routinely performed. Therefore, current study was conducted to evaluate the correlation of NAC-induced CD8+ T cell with chemotherapy response based on Miller Payne grading and World Health Organization (WHO) criteria.METHODS: LABC patients were recruited and data regarding age, gender, tumor, nodal stages, histopathological grade, estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and Ki67 were obtained. Biopsy and mastectomy tissues were collected and processed for hematoxylin-eosin and CD8 immunohistochemical staining. CD8+ T cell expression in peritumoral and intratumoral areas were documented and measured. Clinical responses based on Miller Payne grading and WHO were analyzed and correlated with CD8+ T cell expression.RESULTS: There were more subjects with high expression of total (80%), intratumoral (82.5%) and peritumoral (65%) CD8+ T cell expressions. The total (p=0.013) and intratumoral (p=0.015) CD8+ T cell expression, but not peritumoral CD8+ T cell expression, were significantly correlated with Miller Payne Grading. The total (p=0.009) and intratumoral (p=0.001) CD8+ T cell expressions were also significantly correlated with WHO clinical response.CONCLUSION: Total and intratumoral CD8+ T cell expressions are correlated with Miller Payne grading and WHO clinical response of NAC. Therefore, total and intratumoral CD8+ T cell expressions could be suggested as a predictive marker for clinical response of NAC.KEYWORDS: breast cancer, neoadjuvant chemotherapy, CD8, clinical response, Miller Payne, intratumoral, peritumoral 
Optimalisasi Kesehatan Petani Sawit: Pelatihan Pencegahan Efek Neurobehavior dari Pajanan Toksik Organofosfat di Desa Pulau Lawas, Kabupaten Kampar Ulfah, Ulfah; Rangkuti, Ina Farida; Maulanisa, Sinta Chaira; Fitranda, Mulya; Syaputra, Widi
ABDIMASKU : JURNAL PENGABDIAN MASYARAKAT Vol 8, No 1 (2025): JANUARI 2025
Publisher : LPPM UNIVERSITAS DIAN NUSWANTORO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62411/ja.v8i1.2714

Abstract

Indonesia sebagai negara agraris dengan lebih dari 35 juta petani, menghadapi tantangan terkait pengunaan pestisida, khususnya organofosfat, yang dapat mengganggu fungsi saraf dan menyebabkan efek neurobehavior merugikan. Di Desa Pulau Lawas, Kabupaten Kampar, petani sawit, yang merupakan sumber utama ekonomi lokal, terpapar risiko toksik dari pestisida tersebut tanpa pemahaman yang memadai tentang penggunaan yang aman. Oleh karena itu, program pelatihan untuk meningkatkan pengetahuan dan keterampilan petani dalam pencegahan efek neurobehavior dari pestisida organofosfat sangat penting. Kegiatan ini bertujuan untuk meningkatkan kesadaran petani sawit tentang risiko dan dampak dari pajanan toksik organofosfat serta memberikan keterampilan dan pengetahuan untuk mencegah efek neurobehavior yang merugikan. Hasil kajian ini adalah peningkatan pengetahuan petani tentang pestisida khususnya organofosfat, bahaya dan pencegahan pajanan toksik organofosfat. Pengetahuan petani diukur berdasarkan manajemen pendidikan kesehatan yakni pencegahan (preventif), pengetahuan/peningkatan kesehatan (promotif) dan pertolongan pertama keracunan organofosfat (kuratif), masing-masing didapatkan 63%, 58%, dan 75%.
Differential Effects of Anthracycline-based Neoadjuvant Chemotherapy on Stromal and Intratumoral FOXP3+ Tumor-Infiltrating Lymphocytes in Invasive Breast Cancer of No Special Type Rustamadji, Primariadewi; Wiyarta, Elvan; Pramono, Meike; Maulanisa, Sinta Chaira
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2828

Abstract

BACKGROUND: Neoadjuvant chemotherapy (NAC) plays a crucial role in the management of invasive breast cancer with no special type (IBC-NST), with the immune system's response to cancer heavily relying on the dynamics between tumor-infiltrating lymphocytes (TILs) and cancer cells. In this study, the differential effects of anthracycline-based NAC on stromal and intratumoral foxhead box P3 (FOXP3+) TILs expressions were specifically examined.METHODS: In this cross-sectional study, 32 IBC-NST samples were evaluated for pre- and post-NAC FOXP3+ TIL expression as well as the changes of FOXP3+ TIL expression. Comprehensive data collection regarding subjects' age, tumor size, grade, lymphovascular invasion, regional lymph node metastasis, and receptor status were conducted. Immunohistochemistry was utilized to quantify FOXP3+ TILs. The stromal, intratumoral and total FOXP3+ TILs expression were then analyzed.RESULTS: Significant reductions in FOXP3+ TIL expression post-NAC were observed, with stromal FOXP3+ TILs showing a median decrease of 3.6 units in subjetcs aged ≥50 years (p=0.013) and a median decrease of 13.2 units in subjects with tumors ≥5 cm after NAC (p=0.006). In contrast, intratumoral FOXP3+ TILs remained relatively stable, with minor changes. The total FOXP3+ TIL expression, combining stromal and intratumoral components, was significantly decreased with a median of 13.0 units decreased to 5.3 units (p<0.001).CONCLUSION: This study highlights the significant reduction in stromal FOXP3+ TIL expression after NAC treatment in IBC-NST subjects, in contrast to the relatively stable intratumoral FOXP3+ TILs. Understanding these differences may guide future therapeutic strategies and improve treatment outcomes for IBC-NST.KEYWORDS: biomarkers, chemotherapy, FOXP3, prognostic, response, lymphocyte 
Serum Prolactine Levels and Prolactine Receptor Expression in Premenopausal Breast Cancer: A Potential Predictive Biomarker? Tripriadi, Effif Syofra; Maulanisa, Sinta Chaira; Lipoeto, Nur Indrawati; Yanwirasti, Yanwirasti; Oenzil, Fadil; Harahap, Wirsma Arif; Utami, Tania Nugrah; Mardhiyah, Farah
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52299

Abstract

Introduction: Premenopausal breast cancer (PBC) is often more aggressive than postmenopausal cases, with prolactin playing a key role in tumor development. This study examines the relationship between serum prolactin levels, prolactin receptor (PRLR) expression, and clinicopathological features in PBC patients. Methods: This cross-sectional study was conducted from 2021 - 2022 at multiple hospitals in Pekanbaru, Indonesia. Thirty-five PBC patients and 35 healthy controls were included. Serum prolactin levels were measured using ELISA, and PRLR expression was assessed via IHC. Statistical analysis was performed using independent t-tests and correlation analysis (p < 0.05). Results: PBC patients had higher prolactin levels (51.96±80.40 ng/mL) than controls (20.83±15.74 ng/mL, p = 0.031). PRLR expression was detected in over 90% of tumors, with a significant correlation between prolactin levels and cancer stage (p = 0.035). Discussion: These findings suggest prolactin contributes to PBC progression, with higher levels linked to advanced stages, possibly through JAK2/STAT5 signaling. Conclusion: Serum prolactin levels and PRLR expression are associated with cancer stage, supporting their potential as biomarkers for early detection and disease progression. Further studies are needed for validation.
Total Colonic Tubular Duplication Associated With Anorectal Malformation: A Case Report and Surgical Reconstruction Approach Gusnanda, Dhon Rizal; Ismar, Ismar; Wahid, Tubagus Odih Rhomdani; Amri, Khairuli; Valentino, Andrea; Maulanisa, Sinta Chaira
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52465

Abstract

Total colonic duplication is an exceptionally rare subtype of gastrointestinal duplication, often associated with anorectal malformations. Diagnostic difficulty arises from variable morphology, shared mesenteric structures, and inconsistent imaging findings. Early recognition remains limited, and many cases are identified only during operative exploration. A 10-month-old male with a history of anorectal malformation previously treated with colostomy underwent evaluation for definitive repair. Intraoperative assessment, including loop colonography, identified two parallel colonic lumens extending from cecum to rectum. Exploratory laparotomy confirmed complete tubular duplication with a shared mesentery. Reconstruction was achieved through a side-to-side window anastomosis using a stapling device, followed by creation of a protective ileostomy. Postoperative recovery was uneventful, with adequate stoma perfusion and preserved bowel function. The patient remained stable during follow-up and was scheduled for staged abdominoperineal anoplasty. Complete colonic duplication may not be detected preoperatively and frequently requires intraoperative confirmation. Preservation of vascular supply and staged reconstruction are central to optimizing outcomes.Individualized surgical planning and careful anatomical delineation support favorable early recovery and functional prognosis in total colonic duplication with anorectal malformation.
Co-Authors Ahmad Kurnia Amri, Khairuli Aria Kekalih Denni Joko Purwanto Effif Syofra Tripriadi, Effif Syofra Fadil Oenzil Ferry Sandra Gusnanda, Dhon Rizal Herqutanto Herqutanto Ismar, Ismar Mardhiyah, Farah Mulya Fitranda Nur Indrawati Lipoeto Pramono, Meike Primariadewi Rustamadji Primariadewi Rustamadji Rangkuti, Ina Farida Sonar Soni Panigoro Syaputra, Widi TB Odih Rhomdani Wahid Ulfah Ulfah Utami, Tania Nugrah Valentino, Andrea Wirsma Arif Harahap Wiyarta, Elvan Yanwirasti Yanwirasti Yefta Moenadjat