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The Effect of Binahong Leaves (Anredera cordifolia Steenis) Extract on Blood Urea Nitrogen (BUN) Creatinine Serum and Renal Histopathology of Male White Rats (Rattus norvegicus) with Diabetes Mellitus Tandi, Joni; Patala, Recky; Towulu, Dessy Gracelia; Lidongi, Putri Marcelita; Handayani, Tien Wahyu; Kanan, Maria
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.85034

Diabetic nephropathy is one of the complications of diabetes mellitus on the pancreas that can end up in chronic pancreas failure. Various treatment options to repair pancreas damage due to diabetic nephropathy, one of which is by using Anredera cordifolia leaves. This study aims to determine the content of secondary metabolites in Anredera cordifolia leaves ethanol extract, and to determine the effective dose of Anredera cordifolia leaves ethanol extract in regenerating male white rat kidney cells. This study uses a laboratory experimental method. This study used 30 rats divided into 6 treatment groups, each group consisting of 5 test animals, namely normal group, negative control, positive control, dose of 25 mg/kg BW, dose 50 mg/kg BW, and dose 100 mg/kg bw. The level of histological damage to the renal tubules was observed with HE staining using an Olympus CX23 microscope. The data from the scoring of the level of renal tubular damage were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test to see the differences between treatments. The results showed that the Anredera cordifolia leaves ethanol extract contained secondary metabolites of alkaloids, flavonoids, saponins, and tannins; Anredera cordifolia leaves ethanol extract has an effect on kidney cell repair; Anredera cordifolia leaves ethanol extract at a dose of 100 mg/kg bw is effective reducing urea and creatinine; with an average decrease of 17.0 and 0.71 mg/dL in repairing kidney cells with an average damage value of 1.

The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin: Efektivitas Ekstrak Etanol Biji Kopi Robusta terhadap Kadar Glukosa Darah, Urea, dan Kreatinin Tikus Putih Jantan yang Diinduksi Streptozotocin Tandi, Joni; Marsella, Mimi; Suarsana, I Made Agus; Dewi, Niluh Puspita; Magfirah, Magfirah; Handayani, Tien Wahyu; Kanan, Maria
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16352

Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose, urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.

Pencegahan Schistosomiasis Menggunakan Ekstrak Biji Pinang di Desa Alitupu: Prevention of Schistosomiasis Using Areca Nut Seed Extract in Alitupu Village Handayani, Tien Wahyu; Triposa, Vivi Gretia; Asti, Nurul; Dewi, Ni Made Sinta
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i3.6221

Schistosomiasis is a disease condition that can be acute or chronic, caused by infection with Schistosoma blood worms from the genus Schistosoma. This disease is endemic in Central Sulawesi Province. Transmission occurs through water containing Schistosoma worm larvae (cercariae) and Oncomelania water snails. Hopefully, this service can educate the public about schistosomiasis and anticipate the prevention of schistosomiasis in Alitupu Village District. North Lore, Kab. Poso. Lectures were carried out in this community service activity, and satisfaction levels were calculated using 20 respondents. The instrument used for this service is a questionnaire. This service was carried out in Alitupu Village, District. North Lore, Kab. Poso, Central Sulawesi. The results of the community satisfaction assessment showed that, in general, partners were satisfied with the activities (85%) and community understanding (85%), and 85% of the material delivered was in line with community expectations and needs. Based on the results of community satisfaction, it can be concluded that the community is delighted (83.3%).

Edukasi Jamu Dan Obat Herbal: Manfaat, Risiko, Dan Cara Penggunaan Yang Tepat Tandi, Joni; Handayani, Tien Wahyu; Mariyani, Mariyani; Tandy, Putri Adam
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 5 No. 6 (2025): November 2025 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v5i6.882

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan masyarakat tentang pemanfaatan jamu dan obat herbal sebagai alternatif pengobatan yang aman dan efektif. Kegiatan dilaksanakan pada hari Sabtu, 26 Juli 2025 di Jl. Emmy Saelan No.106, Kelurahan Tatura Utara, Kecamatan Palu Selatan, RT 01, RW 08 yang dihadiri oleh 43 warga masyarakat. Metode yang digunakan adalah participatory learning melalui ceramah, diskusi, dan tanya jawab. Hasil menunjukkan peningkatan pengetahuan masyarakat secara signifikan, dimana persentase peserta yang menjawab "Tidak Tahu" menurun dari 85% menjadi 3,33%, sementara yang menjawab "Tahu" meningkat dari 15% menjadi 96,67% setelah pemaparan materi. Kegiatan ini berhasil memberikan edukasi praktis tentang manfaat, risiko, dan cara penggunaan jamu dan obat herbal yang tepat.

Edukasi Pemanfaatan Gedi Merah Sebagai Obat Dislipidemia Handayani, Tien Wahyu; Tandi, Joni; Alaydus, Syafika; Rajadenda, Afwa Al; Sujati, Ni Wayan
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 4 No. 2 (2024): Volume 4 Nomor 2 Tahun 2024
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v4i2.3702

Indonesia has 143 million hectares of tropical forest which grows 80% of the world's medicinal plants. It is estimated that 25 thousand to 30 thousand plants can be used as medicine. One of these plants is red gedi or Abelmoschus manihot. Apart from having a delicious taste, red gedi leaves also contain many polyphenols, flavonoids, tannins, vitamin A, iron, fiber, folic acid, petroleum, methanol, collagen, vitamin C and several other nutrients which can be useful as a medicine for dyslipedemia. This activity aims to educate the community in Sejahtera Village, Palolo District, Sigi Regency about the use of red gedi as a medicine for dyslipidemia. This service uses lecture methods and distributing brochures. Presentation of the level of public understanding of the benefits of red gedi is 96%, public understanding of dyslipidemia is 95%, and people's skills in processing red gedi into food and drinks that are good for health are 100%.

Edukasi Pemanfaatan Gedi Merah untuk Mengatasi Komplikasi Diabetes Tandi, Joni; Handayani, Tien Wahyu; Aril, Moh; Polakitan, Grace Lovita
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 5 No. 1 (2025): Volume 5 Nomor 1 Tahun 2025 (Maret)
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v5i1.5002

Diabetes mellitus has become a serious health problem in Powelua Village with a prevalence of more than 15% of the adult population, accompanied by complications in vital organs and a high economic burden because the cost of treatment reaches IDR 1.5 million per month per patient. The community service program was implemented through comprehensive education on the use of red gedi to overcome diabetes complications, using lecture methods, interactive discussions, and practical demonstrations. Program evaluation was conducted through questionnaires distributed to 61 participants to measure the level of satisfaction and understanding. The evaluation results showed that the level of participant satisfaction reached an average of 84% (very good category), with three indicators reaching the very good category (80-100%) including the method of delivering material (100%), ease of understanding the material (100%), and the ability of the presenter to answer questions (80%). This program has succeeded in increasing community understanding of the use of red gedi as a safe and affordable alternative treatment for diabetes, although program adjustments are still needed to meet community expectations in future activities.

Edukasi Mengenai Pencegahan dan Pengobatan Schistosomiasis di Desa Dodolo Lore Utara Handayani, Tien Wahyu; Tandi, Joni; Putri, Debby Aulia; Ticoh, Febriyani; Rusdi, Grasela; Uigianto, Imelda; Ahmad, Mirnawati; Safitri, Nabila Umi
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 5 No. 3 (2025): Volume 5 Nomor 3 Tahun 2025
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v5i3.5942

Schistosomiasis is an infectious parasitic disease caused by the Schistosoma worm, transmitted by the snail Oncomelania hupensis lindoensis in endemic areas such as Dodolo Village, Poso Regency, Central Sulawesi. This village has the highest number of intermediate snail foci in the Napu highlands, making it a strategic location for educational interventions. This community service activity aims to improve community knowledge, attitudes, and behavior related to the prevention and treatment of schistosomiasis. Education was carried out using interactive lecture methods, discussions, and pre-test and post-test evaluations of 34 participants from various levels of society. The results showed an increase in the average knowledge score from 3.76 (37.6%) in the pre-test to 8.00 (80.0%) in the post-test, with increased participation and overall understanding. This activity succeeded in building collective awareness and understanding that was evenly distributed throughout the community, and was responded to with a high level of satisfaction (92%). It can be concluded that the participatory education approach is effective in increasing the capacity of the Dodolo Village community in controlling schistosomiasis and can be replicated in other endemic areas as part of a national elimination strategy.

OBAT INFLUENZA DAN UPAYA PENCEGAHAN INFLUENZA DI DESA LAMPO, KECAMATAN BANAWA TENGAH, KABUPATEN DONGGALA, PROVINSI SULAWESI TENGAH Handayani, Tien Wahyu
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 2 No. 1 (2023): Oktober 2023
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2023.v2.i1.16422

Penyakit menular yang disebabkan oleh virus biasanya sering kita jumpai dalam kehidupan sehari-hari mislnya influenza. Influenza adalah infeksi virus yang menyerang hidung, tenggorokan, dan paru-paru. Penderita penyakit tersebut dapat mengalami demam, sakit kepala, pilek, hidung tersumbat, serta batuk. Penyakit ini sering ditemukan dalam kehidupan sehari-hari, tetapi pencegahan dan pengobatannya masih sering diabaikan oleh penderita penyakit tersebut. Oleh karena itu, perlu dilakukannya penyuluhan terkait penyakit influenza mengenai pengobatan dan pencegahannya di masyarakat desa Lampo. Edukasi melalui penyuluhan dengan metode ceramah interaktif. Efektivitas penyuluhan ini dapat diuji dengan pemberian kuisiner kepuasan mitra terhadap kegiatan yang dilaksanakan. Hasil pengamatan kegiatan menunjukkan 95% mitra merasa puas dengan edukasi tersebut.

Edukasi Pengobatan Tradisional Dan Modern Schistosomiasis Di Desa Langko, Kecamatan Lindu Tandi, Joni; Handayani, Tien Wahyu; Arynesta, Teddy; Andini, Tuti Allawiah; Insani, Nabila Nurul; Gintu, Tri Juniver
Yumary: Jurnal Pengabdian kepada Masyarakat Vol. 6 No. 2 (2025): Desember
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i2.3339

Purpose: To provide new knowledge to the Langko Village community about schistosomiasis, which can be treated with synthetic drugs such as praziquantel and anthelmintics, and traditional medicine using betel nuts. Methodology/approach: The PKM activity in Langko Village was carried out in three stages, namely preparation including a location survey to obtain permission from local government officials and prepare the necessary facilities and infrastructure needed during the activity, the second stage is providing education through lectures and material brochures, discussions, and measuring the level of community satisfaction with the activities carried out through activity evaluation by distributing questionnaires, and the third stage is distributing assistance to the community present in the form of basic necessities. Results: The community was very satisfied with this educational activity, with an average satisfaction value of 98% from six satisfaction assessment indicators. Conclusions: The community health education program successfully enhanced local knowledge of schistosomiasis treatment options, demonstrating high community acceptance of both conventional pharmaceutical interventions and traditional betel nut therapy. Limitations: The limitations of this PKM activity have not been able to reach all the snail focus areas because road access is still damaged. Contribution: This PKM has significant implications for public health in Langko Village, where partners feel helped by the new knowledge, namely, betel nut as a medicine for schistosomiasis, which is far from side effects compared to chemical drugs.

Edukasi Pengobatan Tradisional Dan Modern Schistosomiasis Di Desa Langko, Kecamatan Lindu Tandi, Joni; Handayani, Tien Wahyu; Arynesta, Teddy; Andini, Tuti Allawiah; Insani, Nabila Nurul; Gintu, Tri Juniver
Yumary: Jurnal Pengabdian kepada Masyarakat Vol 6 No 2 (2025): Desember
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/yumary.v6i2.3339

Purpose: To provide new knowledge to the Langko Village community about schistosomiasis, which can be treated with synthetic drugs such as praziquantel and anthelmintics, and traditional medicine using betel nuts. Methodology/approach: The PKM activity in Langko Village was carried out in three stages, namely preparation including a location survey to obtain permission from local government officials and prepare the necessary facilities and infrastructure needed during the activity, the second stage is providing education through lectures and material brochures, discussions, and measuring the level of community satisfaction with the activities carried out through activity evaluation by distributing questionnaires, and the third stage is distributing assistance to the community present in the form of basic necessities. Results: The community was very satisfied with this educational activity, with an average satisfaction value of 98% from six satisfaction assessment indicators. Conclusions: The community health education program successfully enhanced local knowledge of schistosomiasis treatment options, demonstrating high community acceptance of both conventional pharmaceutical interventions and traditional betel nut therapy. Limitations: The limitations of this PKM activity have not been able to reach all the snail focus areas because road access is still damaged. Contribution: This PKM has significant implications for public health in Langko Village, where partners feel helped by the new knowledge, namely, betel nut as a medicine for schistosomiasis, which is far from side effects compared to chemical drugs.

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