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All Journal Majalah Obat Tradisional Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Handayani, Tien Wahyu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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The Effect of Binahong Leaves (Anredera cordifolia Steenis) Extract on Blood Urea Nitrogen (BUN) Creatinine Serum and Renal Histopathology of Male White Rats (Rattus norvegicus) with Diabetes Mellitus Tandi, Joni; Patala, Recky; Towulu, Dessy Gracelia; Lidongi, Putri Marcelita; Handayani, Tien Wahyu; Kanan, Maria
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.85034

Abstract

Diabetic nephropathy is one of the complications of diabetes mellitus on the pancreas that can end up in chronic pancreas failure. Various treatment options to repair pancreas damage due to diabetic nephropathy, one of which is by using Anredera cordifolia leaves. This study aims to determine the content of secondary metabolites in Anredera cordifolia leaves ethanol extract, and to determine the effective dose of Anredera cordifolia leaves ethanol extract in regenerating male white rat kidney cells. This study uses a laboratory experimental method. This study used 30 rats divided into 6 treatment groups, each group consisting of 5 test animals, namely normal group, negative control, positive control, dose of 25 mg/kg BW, dose 50 mg/kg BW, and dose 100 mg/kg bw. The level of histological damage to the renal tubules was observed with HE staining using an Olympus CX23 microscope. The data from the scoring of the level of renal tubular damage were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test to see the differences between treatments. The results showed that the Anredera cordifolia leaves ethanol extract contained secondary metabolites of alkaloids, flavonoids, saponins, and tannins; Anredera cordifolia leaves ethanol extract has an effect on kidney cell repair; Anredera cordifolia leaves ethanol extract at a dose of 100 mg/kg bw is effective reducing urea and creatinine; with an average decrease of 17.0 and 0.71 mg/dL in repairing kidney cells with an average damage value of 1.
The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin: Efektivitas Ekstrak Etanol Biji Kopi Robusta terhadap Kadar Glukosa Darah, Urea, dan Kreatinin Tikus Putih Jantan yang Diinduksi Streptozotocin Tandi, Joni; Marsella, Mimi; Suarsana, I Made Agus; Dewi, Niluh Puspita; Magfirah, Magfirah; Handayani, Tien Wahyu; Kanan, Maria
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16352

Abstract

Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose, urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.
Pencegahan Schistosomiasis Menggunakan Ekstrak Biji Pinang di Desa Alitupu: Prevention of Schistosomiasis Using Areca Nut Seed Extract in Alitupu Village Handayani, Tien Wahyu; Triposa, Vivi Gretia; Asti, Nurul; Dewi, Ni Made Sinta
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 3 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i3.6221

Abstract

Schistosomiasis is a disease condition that can be acute or chronic, caused by infection with Schistosoma blood worms from the genus Schistosoma. This disease is endemic in Central Sulawesi Province. Transmission occurs through water containing Schistosoma worm larvae (cercariae) and Oncomelania water snails. Hopefully, this service can educate the public about schistosomiasis and anticipate the prevention of schistosomiasis in Alitupu Village District. North Lore, Kab. Poso. Lectures were carried out in this community service activity, and satisfaction levels were calculated using 20 respondents. The instrument used for this service is a questionnaire. This service was carried out in Alitupu Village, District. North Lore, Kab. Poso, Central Sulawesi. The results of the community satisfaction assessment showed that, in general, partners were satisfied with the activities (85%) and community understanding (85%), and 85% of the material delivered was in line with community expectations and needs. Based on the results of community satisfaction, it can be concluded that the community is delighted (83.3%).
Co-Authors Asti, Nurul Dewi, Ni Made Sinta Joni Tandi, Joni Lidongi, Putri Marcelita Magfirah, Magfirah Maria Kanan Marsella, Mimi Niluh Puspita Dewi, Niluh Puspita Recky Patala Suarsana, I Made Agus Towulu, Dessy Gracelia Triposa, Vivi Gretia