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The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin: Efektivitas Ekstrak Etanol Biji Kopi Robusta terhadap Kadar Glukosa Darah, Urea, dan Kreatinin Tikus Putih Jantan yang Diinduksi Streptozotocin Tandi, Joni; Marsella, Mimi; Suarsana, I Made Agus; Dewi, Niluh Puspita; Magfirah, Magfirah; Handayani, Tien Wahyu; Kanan, Maria
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16352

Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose, urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.

Antioxidant, analgetic, and anti-inflammatory activity test of purple leaf ethanol extract (Graptophyllum pictum L. Griff) in vitro and in vivo Ocvinta, Sisca; Dewi, Niluh Puspita; Utami, Indah Kurnia; Darmayanti, Darmayanti; Alaydrus, Syafika; Anwarudin, Wawang
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.29070

Purple leaves are one of the plants that are widely used as medicine. Purple leaves have 3 types of plant varieties, namely purple leaves, green leaves, and white mottled leaves. Purple leaves have pharmacological activities that can be used as medicine, including antioxidants (improving the deterioration of cells in the body), anti-inflammatory (reducing or suppressing inflammation), antidiabetic (lowering blood glucose levels), analgesics (relieving pain), immunomodulators (increasing the work of the immune system in the body), antihemorrhoids (treating symptoms and complaints of hemorrhoids), and antibacterial (as an antiseptic). The purpose of this study was to determine the antioxidant activity of purple leaf ethanol extract (Graphtophyllum pictum (L.) Griff) in vitro using the DPPH method and to determine its effectiveness as an analgesic and anti-inflammatory against Wistar rats.The results showed that antioxidant activity showed an IC50 value of 72.31 ppm (strong antioxidant). Meanwhile, in the analgetic test, the highest percentage of analgesic effectiveness was found at a dose of 100 mg/kg BW (129.64%) and showed anti-inflammatory activity at a dose of 100 mg/kgBW with a percentage decrease in edem volume of 28.73% at the sixth hour.

ANALISIS POLA PENGGUNAAN OBAT ANTIEPILEPSI DI INSTALASI RAWAT INAP RUMAH SAKIT UMUM DAERAH MADANI PROPINSI SULAWESI TENGAH Dewi, Niluh Puspita
Jurnal Farmaku (Farmasi Muhammadiyah Kuningan) Vol. 5 No. 1 (2020): Volume 5 Nomor 1 Maret 2020
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/jurnalfarmaku.v5i1.103

Penyakit epilepsi adalah gangguan saraf yang timbul secara tiba-tba dan berkala, biasanya dengan perubahan kesadaran. Penelitian ini bertujuan untuk mengetahui karakteristik pasien epilepsi (jenis kelamin, usia, lama perawatan rawat inap, lama pengobatan) dan untuk menganalisis rasionalitas penggunaan obat yang meliputi ketepatan obat, ketepatan dosis, ketepatan frekuensi pemberian, ketepatan lama pemberian dan ketepatan penderita. Data yang digunakan secara retrsopektif yang diolah dengan menggunakan analisis deskriptif dalam bentuk persentase. Hasil penelitian menunjukkan bahwa data pasien epilepsi terbanyak berdasarkan jenis kelamin yaitu laki-laki sebanyak 56,67%, berdasarkan usia yaitu usia 27-37 tahun sebanyak 40%, berdasarkan lama rawat inap yaitu selama Ã¢â€°Â¤ 7 hari sebanyak 66,67%. Obat-obat yang digunakan pasien epilepsi di RSUD Madani yaitu phenitoin 52 pasien, phenobarbital 25 pasien, carbamazepine 22 pasien, diazepam 15 pasien, dan asam valproate 10 pasien. Penggunaan obat pasien epilepsi di RSUD Madani tahun 2010-2012 sudah rasional.

COST MINIMIZATION ANALYSIS OF ANTIHYPERTENSIVE DRUG USE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS Utami, Indah Kurnia; Rakanita, Yasinta; Dewi, Niluh Puspita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1655

Hypertension is the primary cause of Chronic Kidney Disease (CKD), as it damages blood vessels in the kidneys. The most commonly used management for hypertension as monotherapy includes Calcium Channel Blockers (CCB) such as Amlodipine and Angiotensin Receptor Blockers (ARB) such as candesartan. Patients with CKD undergoing hemodialysis depend on dialysis machines, which impacts their economic burden. Therefore, a cost analysis review of drugs with the same therapeutic goals is necessary. This was a non-experimental study with a descriptive design. Data were collected through retrospective purposive sampling from January to December 2023 using medical records and payment data for inpatient treatments with hemodialysis that met the inclusion criteria. Direct medical costs included antihypertensive, other medication, service and facility fees, and medical support costs. Of the 100 samples that met the inclusion criteria from January to December 2023, amlodipine was the most commonly used antihypertensive (56%), followed by candesartan (38%). The average direct medical costs were IDR 184.350 for Amlodipine and IDR 561,339 for candesartan. The patient characteristics by gender showed a higher percentage of males (52%) than of females (48%). By age, the majority were in the late adult group (67%), whereas the elderly accounted for (33%). The Amlodipine group achieved more significant cost minimization than the candesartan group. Future studies should examine the potential of amlodipine in reducing the economic burden of limited resources. Keywords: antihypertensive, CMA, CKD

Edukasi Pemanfaatan Daun Tembelekan sebagai Antiseptik Luka Bakar di RT 09 Kelurahan Lambara Kecamatan Tawaeli Sulawesi Tengah: Education on the Use of Tembelekan Leaves as an Antiseptic for Burns in RT 09, Lambara Village, Tawaeli District, Central Sulawesi Magfirah, Magfirah; Dewi, Niluh Puspita; Halik, Nur
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. Suppl-1 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10iSuppl-1.9222

First aid is the initial treatment for handling burns with the use of natural ingredients that are fast and precise and can improve the healing process, prevent the severity of injuries, reduce pain, and save lives. This community service activity aims to increase public knowledge about the use of tembelekan leaves as first aid for burns. The community service method is carried out by providing socialization in the form of counseling which is followed by a discussion session, questions and answers, and distributing questionnaires to measure community satisfaction with the service. Community service was carried out on November 30, 2024, with the target of the activity being the community in the Lambara Village Area, especially RT 09. The results of community satisfaction with the service carried out were community satisfaction with the method of delivering PKM material, the PKM program was by community needs, the PKM program improved thinking skills, the PKM program could be applied by the community and the community was willing to participate/get involved again, the average result was very satisfied, namely 90.83%, It can be concluded that this PKM activity is very beneficial for the Lambara Village community, especially RT 09.

Uji Ekstrak Alkohol Daun Mengkudu (Morinda Citrifolia L) terhadap Konsentrasi Kreatinin dan Ureum Tikus Putih Jantan (Rattus Norvegicus) Nefropati Diabetes Tandi, Joni; R, Yana Novika; Lakiu, Debora Rislianti; Magfira; Dewi, Niluh Puspita
Jurnal Jamu Indonesia Vol. 8 No. 1 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i1.241

Diabetic nephropathy is one of the microvascular complications of diabetes mellitus (DM). One of the clinical signs of diabetic nephropathy is an increase in urea and creatinine levels. The use of medicinal plants containing antioxidants is one of the therapeutic strategies to prevent complications of DM. The noni plant (Morinda citrifolia L), especially the leaves, contains active substances that have the potential as antioxidants to be used as supportive therapy for DM. This study aims to identify the content of active substances in noni leaf extract and determine the potential of noni leaf extract to reduce creatinine, and urea levels in diabetic nephropathy rats. Noni leaf extract was obtained by maceration using 96% ethanol, and animal models of diabetic nephropathy were obtained by induction of streptozotocin 40 mg/kg BW. The test animals were divided into six groups, namely normal control, negative control, positive control, treatment 1, 2, and 3, each given extract doses of 250, 500, and 750 mg/kg BW. The results indicated the presence of flavonoids, alkaloids, steroids, saponins, and tannins in the noni leaf extract. Giving noni leaf extract can reduce, urea and creatinine levels significantly compared to negative controls. In conclusion, noni leaf extract can potentially prevent complications of diabetic nephropathy with an effective dose of 250 mg/kg BW.

ANALISIS DAN PENERAPAN DAUN UNGU SEBAGAI ANTIOKSIDAN, ANALGETIK DAN ANTIINFLAMASI PADA MASYARAKAT DI KELURAHAN LAMBARA, KECAMATAN TAWAELI Dewi, Niluh Puspita; Toding, Ficanata A.; Kasim, Athia Kurnia; Liska, Iluh; Wirawan, Wayan
Jurnal Abdi Insani Vol 12 No 4 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i4.2435

Daun ungu (Graptophyllum pictum L. Griff) merupakan tanaman yang banyak dimanfaatkan sebagai obat tradisional oleh masyarakat, karena mengandung berbagai senyawa bioaktif seperti flavonoid, tanin, dan alkaloid. Penggunaan obat herbal kembali diminati masyarakat seiring tren "Back to Nature" terutama setelah adanya wabah pandemi COVID-19. Pemanfaatan daun ungu sebagai antioksidan, analgetik, dan antiinflamasi masih belum diketahui sepenuhnya oleh warga masyarakat Kelurahan Lambara, Kecamatan Tawaeli, sehingga diperlukan edukasi mengenai potensi pemanfaatannya dalam pengobatan. Tujuan pengabdian ini adalah untuk menganalisis kandungan pada daun ungu, menerapkan manfaat daun ungu bagi masyarakat, serta menghimpun data dan informasi dari berbagai sumber literatur sebagai rujukan bagi masyarakat mengenai berbagai manfaat daun ungu agar diketahui oleh masyarakat. Metode yang digunakan adalah persiapan dengan melakukan studi literatur, mengumpulkan dan menganalisis data dari beberapa tulisan yang membahas manfaat daun ungu yang ditinjau berdasarkan zat fitokimia dan aktivitas farmakologisnya serta memberikan informasi kepada masyarakat, dan pendampingan langsung kepada masyarakat. Pengabdian yang telah dilakukan menunjukkan peningkatan pengetahuan masyarakat sebesar 85% dengan kategori sangat baik. Kegiatan penyuluhan diikuti oleh 20 warga di Huntara Kelurahan Lambara melalui metode ceramah dan pembagian leaflet informasi. Pemeriksaan kesehatan gratis berupa pengecekan gula darah, kolesterol, dan asam urat telah diberikan kepada peserta, disertai konsultasi kesehatan dengan apoteker. Pemberian sembako juga dilaksanakan kepada 80 kepala keluarga di daerah tersebut sebagai bentuk dukungan sosial. Masyarakat menunjukkan antusiasme tinggi dalam memanfaatkan daun ungu sebagai alternatif pengobatan dan pewarna alami. Kegiatan pendampingan berhasil meningkatkan pengetahuan masyarakat tentang pemanfaatan daun ungu sebagai antioksidan, analgetik, dan antiinflamasi.

Efektivitas Ekstrak Etanol Biji Alpukat (Persea americana Mill.) Terhadap Kadar Glukosa Darah Tikus Putih Jantan (Rattus Novergicus) Model Hiperkolesterolemia-Diabetes: Effectiveness of Ethanol Extract of Avocado Seeds (Persea americana mill.) on Blood Glucose Levels of Male White Rat (Rattus novergicus) Hipercolesterolemia-diabetes Model Patala, Recky; Dewi, Niluh Puspita; Pasaribu, Meilinda Handayani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Diabetes mellitus is a metabolic disorder characterized by increased blood glucose levels due to a deficiency of insulin secretion or when insulin resistance occurs. Herbal medicine is one alternative method that can be used to control blood glucose levels and prevent complications of diabetes mellitus. One of the medicinal plants is avocado seeds (Persea americana Mill.) The active compounds contained in avocado seeds that have antidiabetic activity are flavonoids, alkaloids, tannins and saponins. This study aims to determine the content of secondary metabolites in the extract of avocado seed, the effect of extract of avocado seed and the dose of extract of avocado seed that is effective in lowering blood glucose levels. This research was a laboratory experiment using a modified randomized controlled pretest and posttest group design. Test animals used were 30 rats which were divided into six treatment groups, namely normal control, negative control, positive control, a dose of 250, 300 and 350 mg/kg groups. The results showed that extract of avocado seed contained secondary metabolites: flavonoids, alkaloids, saponins, and tanins;extract of avocado seed gave effect to decrease blood glucose levels; extract of avocado seed with a dose of 350 mg/kg was effective in lowering blood glucose levelswith an avarage decrease of 99,8 mg/dL.

Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes: Ethanol Extract of Some Cowpea (Vigna unguiculata (L.) Walp) Leaves: Morphometry Study of Pancreatic Islet of Diabetic Rat Model Solehah, Puput Octaviani; Tarusu, Fikhta Agnesya; Tandi, Joni; Dewi, Niluh Puspita; Ratih Lintin, Gabriella Bamba; Fitriana, Yuli; Pakaya, David
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 2 (2019): (October 2019)
Publisher : Universitas Tadulako

Diabetes is characterized by an increasing of blood levels and progressive changes in the structure of pancreatic islet of pancreas. Natural ingredients that contain antioxidants such as some cowpea leaves can be an alternative treatment for diabetes. This study aims to examine the effect of ethanol extract of some cowepea leaves (Vigna unguiculata (L.) Walp) on morphometry (perimeter and diameter) of pancreatic islet of diabetic rat models. The type of research is quasi-experimental with posttest group design. Samples were 30 male wistar rats, age 8 weeks, BW 250-300 grams, that induced by single dose of STZ 40 mg/kg BW. Rats were divided into 5 groups. Group A: normal control, Group B: negative control, Group C: positive control, Group D: DM rats with 100mg/Kg BW extract therapy, Group E: DM rats with 200mg/Kg BW extract therapy, Group F: DM rats with extract therapy 300mg/Kg BW. Blood sugar levels were measured on days 7, 14 and 21. Pancreatic tissue was prepared with 5Î¼m thickness and stained with Hematoxylin Eosin. The sample was observed under 400x magnification microscope. The observation uses Image J software to measure the perimeter and diameter of the pancreatic insula. Data were analyzed by non-parametric Kruskal Wallis and post hoct Mann Whitney statistical tests. Blood glucose level was obtained on 21st day with the highest mean in group B (246.8Â±156.3) and lowest in group A (67.2 Â±7.85), perimeter of pancreatic islet was significantly different (p=0.026), the diameter is significantly different (p =0.046). Ethanol extract of some cowpea (Vigna unguiculata (L.) Walp) leaves with dose of 300mg/kgBB helps to restore the blood and morphometry of pancreatic islet model of diabetic rats.

COST MINIMIZATION ANALYSIS OF ANTIHYPERTENSIVE DRUG USE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS Utami, Indah Kurnia; Rakanita, Yasinta; Dewi, Niluh Puspita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1655

Hypertension is the primary cause of Chronic Kidney Disease (CKD), as it damages blood vessels in the kidneys. The most commonly used management for hypertension as monotherapy includes Calcium Channel Blockers (CCB) such as Amlodipine and Angiotensin Receptor Blockers (ARB) such as candesartan. Patients with CKD undergoing hemodialysis depend on dialysis machines, which impacts their economic burden. Therefore, a cost analysis review of drugs with the same therapeutic goals is necessary. This was a non-experimental study with a descriptive design. Data were collected through retrospective purposive sampling from January to December 2023 using medical records and payment data for inpatient treatments with hemodialysis that met the inclusion criteria. Direct medical costs included antihypertensive, other medication, service and facility fees, and medical support costs. Of the 100 samples that met the inclusion criteria from January to December 2023, amlodipine was the most commonly used antihypertensive (56%), followed by candesartan (38%). The average direct medical costs were IDR 184.350 for Amlodipine and IDR 561,339 for candesartan. The patient characteristics by gender showed a higher percentage of males (52%) than of females (48%). By age, the majority were in the late adult group (67%), whereas the elderly accounted for (33%). The Amlodipine group achieved more significant cost minimization than the candesartan group. Future studies should examine the potential of amlodipine in reducing the economic burden of limited resources. Keywords: antihypertensive, CMA, CKD

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