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All Journal Jurnal Kedokteran Hewan Jurnal Medika Veterinaria
Daud AK, M
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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21. -Amylase and -Glucosidase Inhibitors from Plant Extracts Daud AK, M; Juliani, Juliani; Sugito, Sugito; Abrar, Mahdi
Jurnal Medika Veterinaria Vol 13, No 2 (2019): J. Med. Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v13i2.13819

Abstract

About 80% of diabetic people have come from developing countries. Indonesia is seventh of diabetics. Diabetes is a disease as a result of metabolic disorder that caused by lack of insulin secretion and/or insulin do not work properly, so that the sugar highly accumulated in blood (characterized by hyperglycemia). Normally, range of blood sugar is 70 - 110 mg / dL before meals and less than 140 mg / dL after meals. One therapeutic approach to control blood sugar level is to inhibit the activity of starch hydrolysis enzymes, namely -amylase and -glucosidase. The active compounds of plant extracts have a unique and diverse structure compared to synthetic ones. This characteristics are important because the inhibition of enzyme activity by active compounds from plant extracts is known to make the formation of chemical bonds (affinity) between the active compounds and enzymes. A number of active compounds from plant extracts such as tannins, flavonoids, polysaccharides, saponins, terpenoids are known to inhibit the activity of -amylase and -glucosidase. In this study, we discuss some active compounds that inhibit -amylase and -glucosidase enzyme from plant extracts.
Identification and Molecular Characterization of Newcastle Disease Virus Circulates in some districts in Aceh Daud AK, M; Setiyaningsih, Surachmi; Sudirman, Idwan
Jurnal Kedokteran Hewan Vol 13, No 1 (2019): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v13i1.5832

Abstract

The objectives of this study were to assess the diversity of Newcastle Disease Virus (NDV) isolates; to detect and isolate NDV from poultry; and to identify and characterize NDV by serological and molecular assays. A total of 84 cloacal-oropharynx isolates of poultry was collected from privately owned poultries and poultry markets from 12 districts in Aceh Besar and Banda Aceh. Screening was performed by real time reverse transcriptation-polymerase chain reaction (rRT-PCR) to 15 isolates of poultry. Selected isolates were inoculated in 9-11 days old embryonated specific pathogen free (SPF) eggs and showed positive hemagglutination (HA). Characterization was performed through hemagglutination inhibition (HI) test using Komarov and Hitchner B1 antisera, elution test, RT-PCR and realtime RT-PCR fusion (F). All isolates had a higher affinity to Komarov antisera (titer up to 4 log), indicating virulent strain. This was supported by elution test which showed that 93.66% isolates were virulent and 6 % non-virulent. In conclusion, RT-PCR can detect Matrix gene from 15 isolates (100%), while Fusion gene only detected from 11 isolates (73.3%). rRT-PCR is more capable of detecting antigenic diversity compared to RT-PCR.
Co-Authors Idwan Sudirman Juliani Mahdi Abrar Sugito - Surachmi Setiyaningsih