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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Riki Tenggara
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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DETEKSI ANTIGEN HELICOBACTER PYLORI PADA PASIEN GERD DAN NON-GERD DI RUMAH SAKIT ATMA JAYA Athalia Nofera Kurniawan; Riki Tenggara; Lucky Hartati Moehario
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1234/jinma.v69i8.185

Abstract

Pendahuluan: Helicobacter pylori adalah salah satu bakteri flora normal lambung dan sering diasosiasikan dengan dispepsia, tetapi keterkaitannya terhadap Gastroesophageal Reflux Disease (GERD) masih kontroversial. Diagnosis H. pylori paling sering ditegakkan melalui pemeriksaan histopatologi, tes urease yang invasif, dan urea breath test (UBT) yang relatif mahal. Salah satu uji serologi adalah stool antigen test (SAT) yang lebih murah, non-invasif dan lebih mudah pengerjannya. Penelitian ini bertujuan mendeteksi adanya antigen H. pylori pada pasien GERD dan non-GERD di Rumah Sakit Atma Jaya (RSAJ). Metode: Penelitian ini menggunakan studi potong lintang yang bersifat deskriptif. Inklusi penelitian mencakup pasien dewasa yang dirawat inap pada bulan Agustus 2018 ? November 2018 di RSAJ. Peserta diwawancara dengan kuesioner GERDQ. Sampel feses diperiksa menggunakan SAT (Biocare®). Hasil: Sebanyak 30 responden yang terdiri 22 perempuan dan 8 laki-laki, dengan usia terbanyak adalah kelompok usia dewasa (35?64 tahun). Sebanyak 40% responden termasuk kelompok GERD dengan 75% perempuan. Hasil uji SAT positif pada kelompok GERD 16,67%, non-GERD 11,11% dan hasil uji SAT negatif pada kelompok GERD 91,67%, non-GERD 77,78%. Kesimpulan: Keberadaan antigen H. pylori lebih banyak ditemukan pada perempuan, pada usia dewasa dan tidak ditemukan perbedaan antigen H. pylori pada pasien GERD dan non-GERD di RS Atma Jaya.
Diagnosis and Management Pancolitis in Patient with Ulcerative Colitis Cindy Cindy; Riki Tenggara; Yudistira Panji Santoso; Mario Steffanus
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 2, August 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/112201096-99

Abstract

ABSTRACT Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) that usually affects the rectum and part of the colon, which spreads continuously with no skip area. Pancolitis occurs in 20% of patients with UC. Patients with chronic UC, especially pancolitis, have a higher risk of colon cancer. In patients with pancolitis, the risk of cancer increases by 0.5-1% per year after having 8-10 years of disease. A 72-year-old man came with complaint of bloody-mucus diarrhea associated with abdominal cramps. The colonoscopic appearance of colitis was observed in whole lumen throughout colon. Histopathological analysis demonstrated dense infiltrates of granulocytes and macrophages formed by severe inflammation. Normal appearances were observed in the remaining epithelial cells. No parasites, specific process, or malignancy were found. Moreover, no acid-resistant bacteria were found. However, atypical cells were found in one of the biopsy specimens. The patient was diagnosed with extensive type of severe UC. The initial management of treatment included improvement of his general condition along with antibacterial therapy of metronidazole and ciprofloxacin. Specific treatment of sulphasalazine and prednisone were given after pancolitis appearance was revealed, which has similar clinical manifestations in accordance with UC.   Keywords: pancolitis, ulcerative colitis, chronic diarrhea, inflammatory bowel disease
The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection Riki Tenggara; Visakha Revana Irawan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 2 (2017): VOLUME 18, NUMBER 2, AUGUST 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (373.519 KB) | DOI: 10.24871/182201794-97

Abstract

Background: Helicobacter pylori (H. pylori) infection is the main cause of peptic ulcer disease, gastric mucosa metaplasia, and gastric malignancy. The hypothesis of this study is whether there’s an association between metaplasia and gastric malignancy with H. pylori infection.Method: We conducted a retrospective study on 1.127 dyspepsia subjects who performed endoscopy between 2001 to 2011 at a hospital in North Jakarta. Data is obtained based on endoscopy and histopathology data. Investigation of H. pylori in this study using histopathology examination.Results: Of the 1.127 dyspepsia subjects who performed endoscopy and biopsy, there were 130 (11,54%) H. pylori-positive subjects. Gender proportion was composed of 55,37% men and 44,63% women, with median age was 47 years. On the histopathology examination, we obtained 45 metaplasia subjects with median age of 45 years and 7 malignancy subjects with median age of 64 years. Metaplasia was found in 33 of 997 (3,31%) H. pylori-negative subjects and 12 of 130 (9.23%) H. pylori-positive subjects. All gastric malignancy subjects had H. pylori-negative results.Conclusion: There was an association between metaplasia and H. pylori infection, but no association between gastric malignancy and H. pylori infection.
Co-Authors Athalia Nofera Kurniawan Cindy Cindy Mario Steffanus Purwoko, Agus Visakha Revana Irawan Yudistira Panji Santoso