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EFEK ANTI MIKROBA EKSTRAK BUNGA CENGKEH (SYZYGIUM AROMATICUM) TERHADAP METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)SECARA IN VITRO. Azizah, Afaf; Suswati, Irma; Agustin, Sulistyo Mulyo
Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol 13, No 1 (2017): JUNI 2017
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.686 KB) | DOI: 10.22219/sm.v13i1.5444

Abstract

Methicillin-Resistant Staphylococcus aureus (MRSA) merupakan salah satu bakteri penyebab infeksi, angka kejadiannya cukup tinggi. MRSA resisten terhadap beberapa antibiotik seperti beta-laktam(18%), rifampisin (6,7%), floroquinolon (84%), linezolid (1,3%) dan ampicillin (93,4%). Ekstrak bunga cengkeh mempunyai efek antimikroba karena mengandung eugenol, flavonoid, tannin, saponin, alkaloid dan phenol yang dapat merusak struktur sel bakteri.Penelitian ini bertujuan untuk mengetahui efek antimikroba ekstrak bunga cengkeh (Syzygium aromaticum) terhadap MRSA secara in vitro.Metode yang digunakan experimental post test only group designdengan metode dilusi tabung berbagai konsentrasi ekstrak bunga cengkeh 0,39%, 0,195%, 0,097%, 0,049%, 0,024%, 0,012%, 0,006%, 0,003%. Analisis data menggunakan One Way Anova.Hasil penelitain menunjukkan Kadar Bunuh Minimal (KBM) adalah 0,39%. Uji One Way Anova p=0,000 (p<0,05) menunjukkan terdapat perbedaan signifikan antara konsentrasi ekstrak bunga cengkeh dengan jumlah koloni MRSA. Ekstrak bunga cengkeh dapat membunuh MRSA dengan cara merusak struktur sel bakteri. Kesimpulan yang dapat ditarik adalah ekstrak bunga cengkeh (Syzygium aromaticum) mempunyai efek antimikroba terhadap MRSA secara in vitro. Kata kunci : Ekstrak bunga cengkeh (Syzygium aromaticum), MRSA, KBM.
Factors Affecting Cognitive Function in Elderly Prihanti, Gita Sekar; Wilyani, Dwi; Hanif, Achmad; Azizah, Afaf; Lilo, Atika Rachmania; Imaniah, Humairoh Nur Permata; Fadhila, Nadia Farah; Nastiti, Tiara Andini Putri; Purnama, Wahyu Dwi
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 1 (2025): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.1.2025.67-78

Abstract

Background: The number of cognitive impairments in elderly increases gradually every year. The increasing number of elderly can bring various impacts. It has a positive impact if the elderly are in good health. It becomes a negative impact if the elderly have health problems. Mini-Mental Status Examination (MMSE) is a standard and simple test to evaluate cognitive function in elderly.Objective: To determine factors affecting cognitive function in elderly at Bandar Lor Sub-District, Sukorame Public Health Center, Kediri.Methods: This study used an analytical observational study with a cross-sectional design. The sample is 448, using simple random sampling technique. Respondents filled out MMSE questionnaire. Bivariate data analysis used chi-square test. Multivariate data analysis used a logistic regression test.Results: Factors affecting cognitive function in elderly are age, education, living together, history of illness, social activity, depression, MNA, work, physical activity, and marital status. Meanwhile gender, insomnia, and smoking have no effect. Multivariate test results found 3 factors that most affects cognitive function are depression (p = 0,000; OR 2,773; CI95% 1,643-4,680), MNA (p = 0.006; OR 1,928; CI95% 1,209-3,706), physical activity (p = 0.001; OR 0.926; CI95% 0.144-0.609).Conclusion: Family relationships and social support are essential to improve cognitive function.