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Effect of Chitosan on Histology of Reproductive Organs of Female Wistar Rats (Rattus norvegicus) Exposed to Acetate Lead Purwitasari, Alief Ayu; Rozifa, Annisa' Wigati; Irawan, Dwi Dianita; Kalsum, Umi; Ratnawati, Retty; Nurdiana, Nurdiana; Anita, Kenty Wantri
Jurnal Kedokteran Brawijaya Vol 30, No 4 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2019.030.04.5

Abstract

Lead is one of the pollutants widely spread in the environment because it is not easily decomposed. Lead can affect system functions such as the ovary and endometrium. Lead can trigger oxidative stress by reducing antioxidant enzymes and increasing Reactive Oxygen Species (ROS). Lead can also reduce Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels by disturbing the hypothalamus. Chitosan is an antioxidant compound that can reduce the toxic effects of lead. The purpose of this study was to study the effects of chitosan administration on the diameter of antral follicles, the number of endometrial arterioles, and the thickness of endometrial rats after lead acetate exposure. This study was an experimental laboratory using a posttest-only control group design approach applied on 25 female rats aged 8 weeks old, body weight 125-175 grams. Lead and chitosan were given orally with a sonde. There were 5 groups, namely, negative control group (without any treatment), positive control group (lead 175mg/kg/BW), treatment group 1 (lead 175mg/kg/BW + chitosan 16mg/kg/BW, treatment group 2 (lead 175mg/kg/BW + chitosan 32mg/kg/BW), and treatment group 3 (lead 175mg/kg/BW + chitosan 64mg/kg/BW) for 30 days. The rats were sacrificed at proestrus phase, which was proven from vaginal swab. Observations were carried out using the Hematoxylin Eosin (HE) staining method. The observations were analyzed using One Way ANOVA and followed by Least Significant Differences (LSD) test. The results showed significant results (p-value <0.05). Chitosan can increase the diameter of the antral follicle, increase the number of endometrial arterioles, and increase the thickness of endometrial rats exposed by lead acetate.
PENINGKATAN PENGETAHUAN KADER KESEHATAN MELALUI PROMOSI ASI EKSKLUSIF DIMASA PANDEMI COVID-19 Sulistiyowati, Sulistiyowati; Amalia, Amirul; Irawan, Dwi Dianita
JMM (Jurnal Masyarakat Mandiri) Vol 5, No 4 (2021): Agustus
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v5i4.5135

Abstract

Abstrak: Menurut Organisasi Kesehatan Dunia (WHO) pada tahun 2010, sekitar 1,5 juta bayi 0-6 bulan meninggal karena pemberian makanan tambahan sebelum waktunya. Pemberian ASI Eksklusif di Indonesia sekitar 52%, angka ini belum mencapai target program Kementerian Kesehatan tahun 2014 sebesar 80%. Dalam kondisi pandemi, ibu menyusui merasa minder apakah positif corona atau tidak. Hal ini menimbulkan masalah bagi ibu yang ragu atau khawatir apakah ASI ibu masih aman untuk diberikan kepada bayinya. Pengabdian kepada masyarakat ini bertujuan untuk menambah pengetahuan kader tentang cara memberikan ASI kepada ibu menyusui yang positif COVID-19 menggunakan media secara online. Ilmu yang diperoleh kader dalam kegiatan ini diharapkan dapat memberikan pengetahuan dan mengubah perilaku masyarakat tentang cara menyusui ibu yang positif Covid-19. Dari hasil kegiatan pengabdian masyarakat yang telah dilakukan, terjadi peningkatan pengetahuan yang cukup signifikan tentang ASI eksklusif bagi Kader kesehatan  setelah diberikan pendidikan kesehatan  Abstract:  According to the World Health Organization (WHO) in 2010, 1.5 million infants 0-6 months died due to premature feeding. Breastfeeding (exclusive breastfeeding) in Indonesia is around 52%, this figure has not reached the 2014 Ministry of Health program target of 80%. In a pandemic, breastfeeding mothers feel inferior whether they are positive for Corona or not. This creates problems for mothers who are unsure or worried about whether mother's milk is still safe to give to their babies. This community service aims to increase the knowledge of cadres on how to give breast milk to breastfeeding mothers who are positive for COVID-19 using online media. The knowledge gained by cadres in this activity is expected to provide knowledge and change people's behavior about how to breastfeed mothers who are positive for Covid-19. From the results of community service activities that have been carried out, there has been a significant increase in knowledge about exclusive breastfeeding for mothers with COVID-19 after being promotion. 
The Incident of Sibling Rivalry on Child with Mother Breastfeeding During Pregnancy Rahmawati, Shinta Alifiana; Dewi, Lukyta Pratika; Rohmah, Amrina Nur; Primindari, Risya Secha; Rahmawati, Elia Ika; Irawan, Dwi Dianita
Jurnal Midpro Vol. 14 No. 1 (2022): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v14i1.346

Abstract

The interval of pregnancy needs to be considered for parents in planning pregnancy. Close proximity of births can trigger neglect of the first child physically and psychologically, which can cause jealousy due to the unpreparedness of sharing affection by their parents. If parents cannot share their attention properly, it will cause jealousy in their younger siblings which can lead to competition between siblings or commonly called sibling rivalry. This research is interesting and different from previous research because the informants are children with mothers who are pregnant or mothers who are breastfeeding. The purpose of the study was to determine the incidence of sibling rivalry in children with breastfeeding during pregnancy in the Gunem Public Health Center, Rembang Regency. This research uses a qualitative study using a phenomenological approach. This study uses a qualitative study with in-depth interviews and observations. The findings from this study showed that from six informants, 4 children experienced sibling rivalry and only 2 children did not experience sibling rivalry. The majority of mothers choose to stop breastfeeding their older children. Sibling rivalry by children like children wants to be tries to prevent the mother from breastfeeding her sister, tries to attract the mother's attention and does not allow the mother to carry her sister, even the child does not hesitate to pinch and hit his sister if the older sister feels neglected.
The Effect of Infusion of Basil Leaves (Ocimum Basilicum L) on Pathological Flour Albus in Women of Childbearing Age Sulistiyowati, Sulistiyowati; Irawan, Dwi Dianita; Sari, Ponco Indah Arista
Jurnal Midpro Vol. 14 No. 1 (2022): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v14i1.413

Abstract

Flour albus is one of three women's problems that were originally considered a common problem but eventually become severe and even cause infection. The problem of this research was the high incidence of pathological flour albus. The purpose of this study was to determine the difference in pathological flour albus before and after administration of basil leaf infusion (in women of childbearing age (WUS) at Independent Midwifery Practice Ny. Aida Hartatik, S.ST Dlanggu-Deket-Lamongan. This research applied pre-experimental research design with one-group pre-test-post-test-design approach. The population was all women of childbearing age who experienced flour albus at BPM Ny. Aida Hartatik, S.ST in February-June 2019. The samples were twenty-five women obtained by incidental sampling. The research variables were pathological flour albus and treatment with basil leaf infusion. The data were taken by interview and observation. Then, the data were analyzed by Wilcoxon Signed Rank statistical test with a significant level of = 0.05. The results showed that 64% of women of childbearing age before being given basil leaves increased while 72% of women of childbearing age after being given basil leaf infusion decreased. There were differences in pathological flour albus before and after infusion of basil leaves in women of childbearing age with Z=-2,800 and p=0,000. In addition to being given basil leaf infusion (Ocimum Sanctum L), another effort to overcome this problem is through the participation of health workers in providing early information about the prevention and treatment of pathological flour albus.
PENINGKATAN KESADARAN REPRODUKSI REMAJA MELALUI PROGRAM ‘KAYA DARO’ DALAM PEMBENTUKAN KELOMPOK KADER SEBAYA DI MA MUHAMMADIYAH 9 AL MIZAN LAMONGAN Primindari, Risya Secha; Irawan, Dwi Dianita; Rohmah, Amrina Nur
Health Care : Journal of Community Service Vol. 2 No. 1 (2024)
Publisher : Rena Cipta Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62354/healthcare.v2i1.8

Abstract

Pengetahuan remaja masih terbatas tentang Kesehatan reproduksi di berbagai negara, termasuk di Indonesia. Berdasarkan survey di MA Muhammadiyah 9 AL-MIZAN Lamongan pada siswa kelas 11 didapatkan bahwa 71% pengetahuan kurang memadai dan 29% pengetahuan memadai tentang cara merawat organ reproduksi, anemia, IMS, kehamilan remaja dan permasalahan seksualitas. Dibutuhkan program KAYA DARO yaitu pembentukan kader sebaya pada remaja yang fokus pada kesehatan reproduksi. Tujuanya adalah Peningkatan pengetahuan tentang Kesehatan reproduksi. Tahapan pelaksanaan kegiatan meliputi audiensi, identifikasi permasalahan, penetapan kegiatan, persiapan kegiatan, pembentukan kader dan pemberian materi kepada kader, penyuluhan dari kader ke remaja dan evaluasi. Materi yang diberikan meliputi personal hygiene. Kehamilan remaja, permasalahan seksualitas, infeksi menular seksual.  Hasil evaluasi menunjukan bahwa kegiatan pengabdian dapat membentuk kader sebaya dan meningkatkan pengetahuan remaja MA Muhammadiyah 9 Al Mizan Lamongan tentang Kesehatan reproduksi.
In vivo study: black cumin extract (Nigella sativa) on antral follicle diameter and granulosa cell layer thickness as an effort to prevent infertility Amalia, Amirul; Primindari, Risya Secha; Irawan, Dwi Dianita
MEDISAINS Vol 22, No 2 (2024)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v22i2.23251

Abstract

Background: Infertility is a health problem that affects approximately 10-15% of couples trying to achieve pregnancy worldwide. Various studies have shown that Nigella sativa (N. Sativa) has many health benefits, including reproductive health. However, studies examining the effectiveness of N. Sativa in preventing folliculogenesis disorders have never been reported.Purpose: This study aims to determine the benefits of administering N. Sativa in preventing folliculogenesis disorders as measured by the diameter of the antral follicles and the thickness of the granulosa cell layer.Methods: This research design uses an experiment with a randomized posttest-only controlled group design approach. There were 27 experimental animals (mice) divided into three groups, namely the negative control group (9 animals) and the positive control group (9 animals), as well as the treatment group (9 animals). The positive control group was exposed to two cigarettes of cigarette smoke per day. The treatment group was exposed to cigarette smoke and N. Sativa 300 mg/KgBW/day for 28 days. After that, the mice were sacrificed to take their ovaries. Then, the ovarian organ samples were stained with Hematoxylin-eosin and examined for the diameter of the antral follicles and the thickness of the granulosa cell layer in the antral follicles with photo slides at 400x magnification in 5 fields of view, statistical analysis using the Independent T-test.Results: There were significant differences in antral follicle diameter and granulosa cell thickness in mice exposed to cigarette smoke and N. Sativa. Administration of N. Sativa extract can increase granulosa cell thickness through estrogenic function. Administration of N. Sativa extract showed estrogenic activity by increasing serum estradiol levels. N. Sativa heterotrophic activity cannot be separated from the flavonoid and phenolic compounds contained in N. Sativa, which have been proven to have high estrogenic activity.Conclusion: N. Sativa extract is efficacious in improving the diameter of antral follicles and the thickness of granulosa cells caused by exposure to cigarettes.
Pengaruh penggunaan media sosial terhadap kesehatan mental remaja: Literature review Rahmawati, Shinta Alifiana; Rohmah, Amrina Nur; Irawan, Dwi Dianita; Rahmawati, Elia Ika; Primindari, Risya Secha
Jurnal Riset Kebidanan Indonesia Vol 8, No 2 (2024): Desember
Publisher : AIPKEMA (Asosiasi Institusi Pendidikan Kebidanan Muhammadiyah-'Aisyiyah Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32536/jrki.v8i2.285

Abstract

Latar belakang: Di era digital saat ini, media sosial telah menjadi bagian integral dalam kehidupan sehari-hari. Penggunaannya membawa berbagai dampak, baik positif maupun negatif. Salah satu dampak yang paling mendapat perhatian adalah pengaruh media sosial terhadap kesehatan mental remaja. Tujuan penelitian: Mengetahui pengaruh penggunaan media sosial terhadap kesehatan mental remaja. Metode: Artikel-artikel dalam penelitian ini diperoleh dari database ScienceDirect dan PubMed menggunakan PRISMA Flow Chart. Metode sintesis yang digunakan adalah modifikasi PEOS (Population, Exposure, Objectives, Study design). Pemilihan artikel dilakukan berdasarkan publikasi yang diterbitkan antara tahun 2019 hingga 2023, menghasilkan 10 artikel yang terpilih setelah melalui proses seleksi dari keseluruhan jurnal yang ada. Hasil: Hasil telaah menunjukkan adanya hubungan atau korelasi antara penggunaan media sosial dan kesehatan mental remaja. Temuan ini mengindikasikan bahwa durasi penggunaan, jenis aplikasi yang digunakan serta frekuensinya memiliki pengaruh terhadap dampak negatif yang ditimbulkan pada remaja. Simpulan: Adanya hubungan signifikan antara penggunaan media sosial dan kesehatan mental pada remaja.