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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Kedokteran Gigi Indonesia
Wijaya, Rama Insan Kusuma
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Biochemistry, Genetics & Molecular Biology Dentistry Medicine & Pharmacology

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Analgesic, Anti-Inflammatory and Anti-Biofilm-Forming Activity of Potato (Solanum tuberosum L.) Peel Extract Wahyudi, Ivan Arie; Ramadhan, Fahri Reza; Wijaya, Rama Insan Kusuma; Ardhani, Retno; Utami, Trianna Wahyu
Indonesian Journal of Cancer Chemoprevention Vol 11, No 1 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss1pp30-35

Abstract

The utilization of natural resources, one of which is plants, has been researched as an alternative to synthetic drugs because of their natural content. Potato (Solanum tuberosum L.) peels, the parts of potatoes that are often cut off and discarded, have been reported to have some phenolic compounds and flavonoids in their composition. The extract of potato peels was investigated for its analgesic, anti-inflammatory, and anti-biofilm-forming properties. A hot plate test was conducted to assess the analgesic activity in treatment doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg with paracetamol as the reference drug and distilled water as the negative control, while carrageenan-induced paw edema was used to assess anti-inflammatory activity in treatment doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg with diclofenac as the reference drug and distilled water as the negative control. Anti-biofilm-forming activity was tested by using the crystal violet assay. The results showed that, compared with the negative control, treatment doses of 100 mg/kg and 200 mg/kg significantly (p < 0.05) reduced pain stimuli, whereas a treatment dose of 100 mg/kg, 200 mg/kg, and 400 mg/kg significantly (p < 0.05) reduced the edema volume increment. However, compared with the positive control, paracetamol and diclofenac were associated with the least pain stimulus and the least edema volume increment, respectively. Potato peel extract against S. mutans biofilm formation demonstrated effectiveness (p < 0.05). Based on these data, it can be concluded that potato peel extract has analgesic, anti-inflammatory, and anti-biofilm-forming activities, as demonstrated in this study.
The effect of sodium ascorbate application and intracoronal bleaching on the shear bond strength of composite resin Wijaya, Rama Insan Kusuma; Nugraheni, Tunjung; Untara, Tri Endra
Majalah Kedokteran Gigi Indonesia Vol 11, No 3 (2025): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.107996

Abstract

An increase in the frequency of 35% hydrogen peroxide (HP) application during intracoronal bleaching leads to a higher accumulation of free radical residues, which can negatively affect the bonding of composite resin. The removal of these free radicals can be facilitated by the application of 35% sodium ascorbate (SA) combined with 0.4% surfactant. An additional frequency of SA application is required to counteract the increased free radical residues. This study aimed to evaluate the effect of the frequency of 35% SA combined with 0.4% surfactant and different intracoronal bleaching frequencies on the shear bond strength of composite resin. Forty-eight premolar teeth were divided into two main groups of 24 specimens each. Group I received two applications of 0.01 mL HP 35%, while Group II received three applications. After each bleaching session, the specimens were stored in a closed tube for five days per session, then washed and dried. Each group was further divided into three subgroups. Subgroup A was left untreated for seven days; Subgroup B received two applications of 35% sodium ascorbate combined with 0.4% surfactant; and Subgroup C received three applications. All specimens were restored with composite resin and immersed in pH 7 artificial saliva in an incubator for seven days. Shear bond strength was tested using a Universal Testing Machine at a crosshead speed of 0.5 mm/min. Two-way ANOVA revealed a significant effect of sodium ascorbate application frequency and different intracoronal bleaching frequencies on composite resin shear bond strength (p < 0.01). The results indicate that the shear bond strength of composite resin subjected to three applications of 35% sodium ascorbate combined with 0.4% surfactant is statistically comparable to those obtained with two applications of the same formulation.
Co-Authors Ivan Arie Wahyudi Ramadhan, Fahri Reza Retno Ardhani Tri Endra Untara, Tri Endra Trianna Wahyu Utami Tunjung Nugraheni