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All Journal Jurnal Penelitian Farmasi dan Herbal Buletin Kedokteran dan Kesehatan Prima TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES (TIRES) Journal of Pharmaceutical and Sciences. Jurnal Novem Medika Farmasi
Sembiring, Novitaria Br
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Antibacterial Potential of Parem Karo to Treat Staphyloccocus aureus Infection in Diabetic Foot Patients Tarigan, Jenny Alfa Dilla Br; Sembiring, Novitaria Br; Bangar S., Roy Idrianto
TRANSPUBLIKA INTERNATIONAL RESEARCH IN EXACT SCIENCES Vol. 4 No. 2 (2025): APRIL
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/tires.v4i2.1789

Abstract

One of the chronic and serious complications of diabetes mellitus is diabetic foot. Staphylococcus aureus bacteria is the most common bacteria found in this type of wound. The purpose of this study is to determine the antibacterial activity of parem Karo, which is one of the traditional medicines of the ethnic culture of the Karo tribe which is rich in spices. The results showed inhibitory activity at higher concentrations with the largest average inhibition diameter at 75% concentration against Staphyloccocus aureus bacteria (8.23 ± 0.72 mm) followed by 50% concentration with an average inhibition diameter (7.52 ± 0.2 mm) and at 25% concentration showed no inhibition zone at all. The conclusion obtained from this study is that there is antibacterial activity of Karo hot parem extract at a concentration of 75% and 50% against the growth of Staphyloccocus aureus bacteria.
Skrining Resep untuk Identifikasi Interaksi Obat pada Pasien Diabetes Melitus dan Hiperurisemia Periode Oktober 2023 hingga Maret 2024 di Rumah Sakit Advent Surbekti , Destiana Tata; Sembiring, Novitaria Br; Lubis, Asyrun Alkhairi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.894

Abstract

Background: Diabetes mellitus (DM) and hyperuricemia are frequently encountered comorbidities in clinical practice with increasing prevalence. Long-term pharmacological therapy for these conditions carries the potential for drug interactions and other drug-related problems. Prescription completeness evaluation and drug interaction identification are necessary to ensure therapeutic safety and efficacy. Objectives: This study aimed to identify medications prescribed for patients with DM and hyperuricemia, evaluate potential drug interactions, and assess prescription completeness based on administrative standards according to Indonesian Ministry of Health Regulation No. 72 of 2016. Methods: This retrospective descriptive study with a cross-sectional design analyzed 50 outpatient prescriptions at Advent Hospital Medan from October 2023 to March 2024. The analysis covered administrative, pharmaceutical, and clinical aspects. Drug interactions were identified using Drugs.com with classification as major, moderate, and minor. Results: The most frequently prescribed antidiabetic drugs were metformin (82%), glimepiride (76%), and acarbose (64%), while for hyperuricemia they were allopurinol (88%) and meloxicam (72%). Ten drug interactions were identified, consisting of 8 moderate (80%), 1 major (10%), and 1 minor (10%). Administrative evaluation showed 92% completeness for mandatory components, but patient weight (48%), physician address (64%), and physician phone number (56%) were frequently omitted. Conclusion: The study revealed a significant prevalence of moderate drug interactions between antidiabetic drugs and non-steroidal anti-inflammatory drugs (NSAIDs). Optimization of prescription screening systems and completion of patient clinical data are required to enhance therapy safety.
Efek Nefroprotektif Ekstrak Etanol Jahe Merah (Zingiber officinale var. rubrum) Terhadap Gambaran Histopatologi Ginjal Tikus (Rattus norvegicus) Yang Diinduksi oleh Etilen Glikol Anselia , Bella; Lubis , Asyrun Alkhairi; Sembiring, Novitaria Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1021

Abstract

Background: The kidney is a vital organ susceptible to damage from exposure to nephrotoxic compounds such as ethylene glycol. Red ginger (Zingiber officinale var. rubrum) is known to contain bioactive compounds with antioxidant and anti-inflammatory potential that may protect the kidney from injury. However, its effectiveness as a nephroprotective agent needs to be scientifically validated. Objective: To evaluate the nephroprotective effect of ethanol extract of red ginger against ethylene glycol–induced kidney damage in male white rats (Rattus norvegicus), Wistar strain. Methods: An experimental study using a post-test only control group design was conducted to minimize bias by ensuring equivalent baseline conditions among groups. A total of 25 rats were divided into five groups: normal control (distilled water), negative control (0.75% ethylene glycol), and three treatment groups (ethylene glycol + red ginger extract at doses of 100, 200, and 300 mg/kgBW/day). Parameters measured included serum creatinine levels and kidney histopathology. Data were analyzed using one-way ANOVA (p < 0.05) followed by LSD post hoc test. Results: Red ginger extract significantly reduced serum creatinine levels (p < 0.05), with the greatest reduction observed at a dose of 300 mg/kgBW (0.528 ± 0.082 mg/dL). Histopathological improvement of the kidney was also evident, indicated by decreased necrosis, cellular degeneration, and inflammatory cell infiltration. The kidney damage score in the treatment groups (score 1) was lower than in the negative control group (score 2). Conclusion: Ethanol extract of red ginger exhibits a nephroprotective effect against ethylene glycol–induced kidney injury, with the optimal dose being 300 mg/kgBW/day. These findings support the potential of red ginger as an alternative therapy for kidney disorders, although further studies are needed to elucidate the molecular mechanisms and conduct clinical trials.
POTENSI ANTIBAKTERI PAREM KARO UNTUK MENANGANI INFEKSI Staphylococcocus aureus PADA PENDERITA DIABETIC FOOT Br Tarigan, Jenny Alfa Dilla; Sembiring, Novitaria Br; Bangar S, Roy Idrianto
Jurnal Penelitian Farmasi Dan Herbal Vol 8 No 1 (2025): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v8i1.2411

Abstract

One of the cronic and serious complications of diabetes mellitus is diabetic foot. Staphyloccocus aureus bacteria is the most common bacteria found in this type of wound. The purpose of this study is to determine the antibacterial activity of parem Karo, which is one of the traditional medicines of the ethnic culture of the Karo tribe which is rich in spices. Testing the antibacterial activity of Karo hot parem against staphylococcus aureus bacteria using disc diffusion method with 255, 50% and 75% concentration of Karo hot parem extract, positive control Ciprofloxacin Disks (5µg) and negative control DMSO 10%. This disc diffusion method was carried out to determine the diameter of the inhibition formed by Karo hot parem extract in inhibiting the growth of Staphyloccocus aureus bacteria. The results showed inhibitory activity at higher concentrations with the largest average inhibition diameter at 75% concentration against Staphyloccocus aureus bacteria (8.23 ± 0.72 mm) followed by 50% concentration with an average inhibition zone at all. The conclusion obtained from this study is that there is antibacterial activity of Karo hot parem extract at a concentration of 75% and 50% against the growth of Staphyloccocus aureus bacteria.
Effectiveness test of avocado seeds on the renal histopathology of white rats induced by isoniazid Lubis, Khairunnisya; Lubis, Asyrun Alkhairi; Sembiring, Novitaria Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7692

Abstract

The kidneys are a pair of organs within the urinary system, located in the upper retroperitoneal cavity, functioning in blood filtration, reabsorption, and secretion through diffusion processes involved in blood purification and urine formation. The kidneys are highly susceptible to damage from exposure to nephrotoxic drugs, one of which is isoniazid. Avocado seeds (Persea americana Mill.) are known to contain antioxidant compounds with potential protective effects against renal tissue damage. This study aimed to examine the effect of avocado seed extract on the histopathological changes in the kidneys of white rats induced with isoniazid. The research employed an experimental design using 25 male rats divided into five groups: positive control (K+), negative control (K–), and three treatment groups receiving avocado seed extract at doses of 100 mg/kg body weight (P1), 200 mg/kg body weight (P2), and 400 mg/kg body weight (P3). Isoniazid induction was administered to all groups except the positive control. After a 14-day treatment period, kidney samples were collected for histopathological analysis using hematoxylin-eosin (HE) staining. The observations indicated that avocado seed extract effectively improved renal histological structure in white rats (Rattus norvegicus) induced with isoniazid. In the treatment group III, renal histological improvement was observed, with only 5–25% structural damage or a score of 1, compared to groups I and II, which showed 25–50% damage or a score of 2.
Skrining Fitokimia Dan Profil Total Fenol Serta Flavonoid Pada Ekstrak Daun Seledri (Apium graveolens L.) Situmorang, Carmenita M. Cindy Tiara; Yunus, Muhammad; Sembiring, Novitaria Br
Jurnal Novem Medika Farmasi Vol. 5 No. 1 (2026): volume 5 issue 1 2026
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v5i1.2174

Abstract

ABSTRAK Daun seledri (Apium graveolens L.) merupakan salah satu tanaman herbal yang diketahui mengandung senyawa metabolit sekunder yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui golongan senyawa yang terkandung serta menentukan kadar total fenol dan flavonoid pada ekstrak daun seledri. Simplisia daun seledri diekstraksi menggunakan etanol 96% dengan metode maserasi. Skrining fitokimia dilakukan untuk mengidentifikasi kandungan senyawa metabolit sekunder. Penetapan kadar total fenol menggunakan metode Folin–Ciocalteu dengan baku pembanding asam galat dan pengukuran pada panjang gelombang 765 nm. Penetapan kadar total flavonoid menggunakan metode kompleksasi AlCl3 dengan baku kuersetin pada panjang gelombang 434 nm. Hasil penelitian menunjukkan bahwa ekstrak daun seledri mengandung flavonoid, alkaloid, polifenol, tanin, sterol, dan triterpenoid. Kadar total fenol sebesar 209,79 mg GAE/g ekstrak dan kadar total flavonoid sebesar 12,50 mg QE/g ekstrak.
Efikasi Gel Ekstrak Daun Seledri (Apium graveolens L.) terhadap Gambaran Makroskopik Ulkus pada Model Tikus Diabetes induksi Aloksan Putri, Tamy Yolanda; Yunus, Muhammad; Sembiring, Novitaria Br
Jurnal Novem Medika Farmasi Vol. 5 No. 1 (2026): volume 5 issue 1 2026
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v5i1.2175

Abstract

Diabetes melitus masih menjadi penyakit dengan angka penderita yang terus meningkat setiap tahun dan masih menjadi masalah utama dalam kesehatan di seluruh dunia. Tanaman herbal yang digunakan sebagai alternatif pengobatan yaitu daun seledri (Apium graveolens L.). Penelitian ini bertujuan untuk melihat pengaruh perbedaan konsentrasi ekstrak daun seledri dalam sediaan gel terhadap proses penyembuhan ulkus pada model tikus diabetes yang diinduksi aloksan. Penelitian ini dibagi dalam enam kelompok. Kelompok ini terbagi atas : Kelompok normal, kelompok negatif, kelompok positif, kelompok perlakuan 1 dengan pemberian ekstrak daun seledri konsentrasi 5 %, kelompok perlakuan 2 dengan pemberian ekstrak daun seledri 10 %, dan kelompok perlakuan 3 dengan pemberian ekstrak daun seledri konsentrasi 15 %. Parameter pengamatan yang digunakan adalah diameter ulkus selama 14 hari. Hasil penelitian menunjukkan bahwa evaluasi maksroskopik paling baik terdapat pada kelompok perlakuan 2 dengan gel daun seledri konsentrasi 10 % dan kelompok perlakuan 3 dengan gel daun seledri konsentrasi 15 %. Hal ini membuktikan bahwa gel ekstrak daun seledri (Apium graveolens L.) memiliki potensi sebagai alternatif terapi penyembuhan ulkus pada kondisi diabetes akibat induksi aloksan.
Formulasi Krim yang Mengandung Ekstrak Biji Kopi Robusta (Coffea canephora L.) dan Tantangannya dalam Menghambat Staphylococcus aureus: Studi Potensi Terapi Luka pada Penderita Diabetes Andari, Putri; Sembiring, Novitaria Br; Ginting, Astriani Natalia Br
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1425

Abstract

Diabetes mellitus is a chronic metabolic disorder that can cause wounds that are difficult to heal and susceptible to bacterial infection, especially Staphylococcus aureus. This study aims to formulate an antibacterial cream preparation containing robust coffee bean extract (Coffea canephora L.) and evaluate its activity against Staphylococcus aureus. The extract was obtained through maceration with 96% ethanol with a crude yield of 30% and an extract yield of 14.05%. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, phenols, saponins, and terpenoids. Antibacterial testing of the extract showed inhibitory activity against Staphylococcus aureus at concentrations of 30% (7.73–8.44 mm) and 50% (8.52–13.16 mm). The extract was then formulated into creams with varying concentrations of 0%, 30%, and 50%. All formulations met the physical parameters, except for the cream that did not contain the extract, which showed a pH higher than the ideal range for topical application and showed a decrease in spreadability with increasing extract concentration. However, testing the antibacterial activity of the cream preparations using the disk diffusion method did not produce an inhibition zone in any of the formulations tested. The results of this study indicate that although Robusta coffee bean extract shows activity in vitro, it has not been successfully applied in cream formulations with the existing bases and testing methods. These findings highlight the major challenges in developing natural topical preparations, particularly regarding the selection of formulation bases and appropriate evaluation methods for semisolid preparations.
Co-Authors ANDARI, Putri Anselia , Bella Asyrun Alkhairi Lubis Bangar S, Roy Idrianto Bangar S., Roy Idrianto Br Tarigan, Jenny Alfa Dilla Ginting, Astriani Natalia Br Lubis, Khairunnisya Muhammad Yunus Putri, Tamy Yolanda Situmorang, Carmenita M. Cindy Tiara Surbekti , Destiana Tata Tarigan, Jenny Alfa Dilla Br