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All Journal Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Health & Medical Sciences Jurnal Indah Sains dan Klinis
Simanjuntak, Nerly Juli Pranita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Potensi Antihiperglikemia Kombinasi Ekstrak Daun Salam dan Ikan Gabus Razoki, Razoki; Simanjuntak, Nerly Juli Pranita
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.04

Abstract

Background: Flavonoids, as secondary metabolites found in bay leaves, exhibit antioxidant properties that help prevent damage to pancreatic β cells by neutralizing free radicals responsible for cell injury. Protein from snakehead fish plays a role in regulating blood sugar levels by inhibiting the α-glucosidase enzyme. Objective: This study aimed to assess the potential of combining the two extracts to lower blood sugar levels in mice. Method: Six groups were used in the study, each receiving a 250 mg/kg BW dose and 40% glucose inducer: Aquades (A), ethanol extract of bay leaves (EEDS), snakehead fish extract (EIG), and combinations of ethanol extracts of bay leaves and snakehead fish (EEDS-IG) in ratios of 1:1, 2:1, and 3:1 (w/w). Results: The study revealed that EEDS and EIG reduced blood sugar levels by 12.14%, 66.9%, 55.0%, 69.3%, 69.7%, and 69.3% at the 120th minute, respectively, for each group. Conclusion: The combination of EEDS and EIG has the potential to reduce blood sugar levels, particularly at a 2:1 ratio
Antioxidant Activity Test of The Aqueous Fraction of Tetanus Leaves (Leea aequata L.) Using The DPPH Method Siregar, Nurhakiki; Bangar, Roy Indrianto; Kaban, Vera Estefania; Simanjuntak, Nerly Juli Pranita
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 01 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i01.85

Abstract

Antioxidants play a crucial role in neutralizing free radicals, thereby helping to prevent cell damage and maintain overall health. This study aims to evaluate the antioxidant activity of the aqueous fraction of Tetanus (Leea aequata L.) leaf extract using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The extraction process was carried out through maceration using ethanol as a solvent, followed by aqueous fractionation. Antioxidant activity was measured based on the extract’s ability to scavenge DPPH free radicals, expressed as the IC₅₀ value. The results showed that the aqueous fraction of Tetanus leaf extract exhibited high antioxidant activity, with an IC₅₀ value of 30.23 mg/L. The total phenolic and flavonoid contents in the aqueous fraction were 460.70 mg GAE/100g and 12,621.14 mg QE/100g, respectively. These findings align with pre vious studies indicating that the ethanolic extract of Leea angulata leaves also possesses strong antioxidant activity with a similar IC₅₀ value. Therefore, the aqueous fraction of Tetanus leaf extract has the potential to be an effective natural antioxidant source and can be further developed as a raw material for health supplements or pharmaceutical products.
Study of Administrative, Pharmaceutical, and Clinical Aspects of Hypertension Patient Prescriptions at Advent Hospital, Medan Saragih, Maria Lady; Simanjuntak, Nerly Juli Pranita; Novriani, Erida
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.111

Abstract

Hypertension is a common chronic disease requiring precise pharmacological management to prevent complications. Inappropriate prescriptions may lead to treatment failure or adverse events. This study aimed to evaluate the completeness of prescriptions for hypertensive outpatients at Advent Hospital Medan based on administrative, pharmaceutical, and clinical aspects. This descriptive retrospective study analyzed 303 prescriptions collected from January to March 2024. Evaluation criteria included patient and prescriber identity, dosage form, drug strength, usage instructions, indication accuracy, dosage accuracy, and potential drug interactions. Results showed administrative completeness was high, with 100% inclusion of most identity elements, but 0% for weight and height. Pharmaceutical completeness was suboptimal, with only 25.08% including dosage form. Clinically, all prescriptions were appropriate in terms of indication, dose, and timing, and showed no duplication. However, 88.11% of prescriptions contained potential drug interactions, with 68 major interactions identified. The most frequent were Amlodipine–Simvastatin and Spironolactone–Candesartan combinations. These findings indicate that while clinical accuracy was excellent, pharmaceutical documentation and interaction screening need improvement. Collaboration between prescribers and pharmacists is essential to enhance medication safety.
Effect of Garlic (Allium sativum) and Turmeric (Curcuma domestica Val.) Extract Combination in Type 2 Diabetic Rats. Ndruru, Titi Marlina; Simanjuntak, Nerly Juli Pranita; Novriani, Erida
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.112

Abstract

Type 2 diabetes mellitus (T2DM) often leads to kidney damage due to chronic hyperglycemia and oxidative stress. Garlic (Allium sativum) and turmeric (Curcuma domestica Val.) are traditional medicinal plants with known antioxidant and anti-inflammatory properties. This study evaluated the nephroprotective effect of their combined extracts in streptozotocin (STZ)-induced diabetic rats. Twenty-five male rats were divided into five groups: negative control, positive control (metformin 500 mg/kg BW), and three treatment groups receiving extract combinations at doses of 100, 200, and 300 mg/kg BW. Blood glucose, urea, and creatinine levels were measured, followed by histopathological examination. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, and other secondary metabolites. Although statistical analysis showed no significant difference in glucose, urea, and creatinine levels among groups (p > 0.05), the 200 mg/kg BW group exhibited the most favorable trends in reduced blood glucose (226.70 ± 89.70 mg/dL) and kidney biomarkers. These results suggest the combination extract may offer protective effects on kidney function in diabetic conditions, warranting further investigation.
The Uji Aktivitas Antibakteri Sediaan Gel Semprot Ekstrak Etanol Daun Sintrong (Crassocephalum crepidiodes) Terhadap Staphylococcus aureus Pada Luka Infeksi Diabetes Mellitus Sipayung, Sry Anita; Natalia , Astriani; Meutia, Rena; Simanjuntak, Nerly Juli Pranita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.887

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder that impairs wound healing. Wounds in diabetic patients tend to heal slowly due to high blood glucose levels that disrupt immune function and blood circulation. Long-term antibiotic use may lead to resistance, necessitating natural antibacterial alternatives such as sintrong leaves (Crassocephalum crepidioides), which contain flavonoids, polyphenols, saponins, and tannins with antibacterial activity. The ethanol extract of sintrong leaves was formulated into a spray gel for its advantages in wound application, including ease of use, sterility, and good penetration ability. Objective: This study aimed to formulate sintrong leaf ethanol extract into a spray gel at various concentrations (5%, 10%, 15%, 20%), evaluate its physical stability, and test its antibacterial activity against S. aureus. Methods: Sintrong leaf extract was obtained through 96% ethanol maceration and formulated into a spray gel using Carbopol 940 as the base. Stability evaluation included organoleptic, viscosity, pH, drying time, and spray pattern tests. Antibacterial activity was assessed using the disc diffusion method. Results: The spray gel exhibited good physical stability over 21 days of storage. Antibacterial testing showed inhibition zones with diameters of 8.05 mm (5%), 8.02 mm (10%), 8.44 mm (15%), and 9.57 mm (20%), indicating moderate effectiveness. The 20% concentration showed the highest inhibition, though lower than the positive control (1% clindamycin). Conclusion: Sintrong leaf ethanol extract can be formulated into a stable spray gel with antibacterial activity against S. aureus, demonstrating the highest efficacy at 20% concentration. This study presents a potential natural alternative for diabetic wound infection treatment.
Rationality of Drug Administration in Patients with Diabetes Mellitus at Royal Prima Hospital Medan Lubis, Graida Tsuraiya; Simanjuntak, Nerly Juli Pranita; Razoki
Health & Medical Sciences Vol. 2 No. 4 (2025): August
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/phms.v2i4.436

Abstract

Acute and chronic diseases caused by poor lifestyle choices or genetics are becoming more common over time and do not seem to be decreasing each year.  This study aims to determine whether the treatment of type 2 diabetes mellitus patients with or without hypertension at Royal Prima Medan Hospital is appropriate.  Descriptive research methodology, namely cross-sectional data, was used in this study.  Retrospective data collection was conducted using information from medical records at one of the Royal Prima Medan University Hospitals from November 2023 to April 2024. Based on 93 medical records, the findings showed that the right drug, right indication, and right dose were all 100% rational.  Moderate drug interactions accounted for 67% of all drug interactions, major interactions 18%, and minor interactions 15%.  In conclusion, Royal Prima University Hospital in Medan had 100% rational medical data for the period November 2023-April 2024.
Antidiabetic Activity Test of Ethanol Extract of Bandotan Leaves (Ageratum conyzoides L.) in Alloxan-Induced White Rats Puput, Puput Virgia Ningrum; Erida Novriani; Simanjuntak, Nerly Juli Pranita
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.96

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels, causing significant morbidity and mortality globally. Indonesia is one of the countries with the highest prevalence of diabetes. This study aimed to evaluate the antidiabetic activity of ethanol extract from Bandotan leaves (Ageratum conyzoides L.) in alloxan-induced diabetic white rats. This experimental research used 30 white rats divided into six groups: normal control (distilled water), negative control (distilled water+alloxan), positive control (glibenclamide 0.65 mg/kg BW+alloxan), and three groups receiving ethanol extract of Bandotan leaves (EEBL) at doses of 100, 200, and 400 mg/kg BW with alloxan induction. Extraction of Bandotan leaves was carried out using the maceration method using 96% ethanol, resulting in a yield of 37,35%. Phytochemical screening showed the extract contained alkaloids, steroids, quinones and saponins. Induction of diabetes was carried out by intraperitoneal injection of alloxan 30mg/kgBB. Blood sugar levels were measured on days 5, 10, 15, 20, 25, 30 after induction. The results showed that administration of EEDB significantly (p<0,005) reduced blood sugar levels with the best effect at a dose of 400mg/kgBB. The ethanol extract of bandotan leaves was proven to have effective antidiabetic activity in alloxan- induced mice, with the potential for development as an affordable and easily accessible alternative diabetes therapy.
Histopathological Features of the Pancreas in Alloxan-Induced Diabetic White Rats Treated with Bandotan (Ageratum conyzoides L.) Extract Hasibuan, Fitriah Parmadami; Novriani, Erida; Simanjuntak, Nerly Juli Pranita
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 3 No. 01 (2025): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/nsmrj.v3i01.99

Abstract

Damage to pancreatic β-cells can lead to hyperglycemia, a hallmark of diabetes mellitus. Ageratum conyzoides L. (bandotan), a plant from the Asteraceae family, is traditionally used in herbal medicine due to its rich content of secondary metabolites. This study aimed to evaluate the histopathological profile of pancreatic tissue in alloxan-induced diabetic rats following treatment with ethanol extract of bandotan leaves. The research employed a true experimental design with a posttest-only control group. A total of 24 white rats were randomly divided into six groups: normal, negative control (aquadest + alloxan), positive control (glibenclamide 0.65 mg/kg BW), and three treatment groups receiving bandotan extract at doses of 100, 200, and 400 mg/kg BW, respectively. Bandotan leaves (4–5 kg) were extracted using ethanol, and histopathological observations were performed under a light microscope at 100x and 400x magnification. Pancreatic damage was scored and analyzed using descriptive statistics. The mean pancreatic damage scores were as follows: negative control group = 1.25; positive control group = 1.00; 100 mg/kg BW group = 1.00; 200 mg/kg BW group = 0.25; 400 mg/kg BW group = 0.00; and normal group = 0.00. The results indicate that the 400 mg/kg BW dose of Ageratum conyzoides L. extract was the most effective in preventing pancreatic damage, with histological features comparable to those of the normal group.
Evaluation of Antibiotic Use in Typhoid Fever Patients at Mitra Sejati General Hospital Using the ATC/DDD Method Ndruru, Masiria; Simanjuntak, Nerly Juli Pranita; Lubis, Razoki
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 3 No. 02 (2025): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v3i02.114

Abstract

The inappropriate use of antibiotics can lead to negative consequences, including the development of resistance, worsening of patient conditions, and an increased burden on healthcare services. Therefore, evaluating antibiotic use through the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method is essential to assess the rationality of therapy, particularly for typhoid fever cases, which remain highly prevalent in Indonesia. This study aimed to evaluate the use of antibiotics in typhoid fever patients at Mitra Sejati General Hospital using the ATC/DDD method. This research was a descriptive study with a cross-sectional design, utilizing patient health records of typhoid fever cases hospitalized from January to March 2024. A total of 72 patients were selected using purposive sampling and compared to WHO standards. The results showed that ceftriaxone (34.7%), levofloxacin (19.4%), and cefixime (16.7%) were the most frequently prescribed antibiotics. Based on the ATC/DDD method, only ciprofloxacin, cefotaxime, and cefadroxil met the WHO DDD standard, while the other seven antibiotics deviated from it. In conclusion, the majority of antibiotic use for typhoid fever patients at Mitra Sejati General Hospital did not comply with WHO standards, indicating the need to strengthen monitoring systems and promote education regarding the prudent and rational use of antibiotics in healthcare facilities
Co-Authors Bangar, Roy Indrianto Erida Novriani Hasibuan, Fitriah Parmadami Lubis, Graida Tsuraiya Lubis, Razoki Meutia, Rena Natalia , Astriani Ndruru, Masiria Ndruru, Titi Marlina Novriani, Erida Puput, Puput Virgia Ningrum Razoki Razoki, Razoki Saragih, Maria Lady Sipayung, Sry Anita Siregar, Nurhakiki Vera Estefania Kaban