Wardhana, Agung Satria
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Chitosan From Haruan (Channa Striata) Fish Scale Accelerate Wound Healing By Promoting Angiogenesis And Fibroblast Proliferation Putri, Deby Kania Tri; Fitriyana, Annisa; Raudah, Siti; Wardhana, Agung Satria; Wydiamala, Erida; Sarifah, Norlaila; Budipramana, Melisa
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.%p

Abstract

Background: Damage to the integrity of some body tissues due to trauma commonly referred to as injury can occur intentionally or unintentionally. Angiogenesis and fibroblast proliferation are important stages in the proliferation stage in determining the success of the wound healing process. Chitosan from haruan fish scales has active functional groups in the form of anti-inflammatory and antioxidants that are effective in accelerating wound healing. Method: This study was a pure experimental study with a post-test only design with a control group design which was divided into a treatment group and a control group. The treatment group consisted of chitosan haruan fish scales at concentrations of 1%, 3%, and 5%. The control group consisted of povidone iodine as a positive control and no treatment as a negative control. All rats were injured on the back and then euthanized on days 3, 5, 7, and 14. Result: The chitosan from haruan fish scales affected the formation of new blood vessels and fibroblasts on day-3, increase the number of new blood vessels on day-5, decrease the number of new blood vessels accompanied by increase the number of fibroblasts on day-7, and also decrease the number of fibroblasts on day-14.Conclusion:  3%, and 5% chitosan from haruan fish scale proved to be effective against angiogenesis and fibroblast proliferation in wound healing. 
Chitosan From Haruan (Channa Striata) Fish Scale Accelerate Wound Healing By Promoting Angiogenesis And Fibroblast Proliferation Putri, Deby Kania Tri; Fitriyana, Annisa; Raudah, Siti; Wardhana, Agung Satria; Wydiamala, Erida; Sarifah, Norlaila; Budipramana, Melisa
Odonto : Dental Journal Vol 11, No 1 (2024): July 2024
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.11.1.%p

Abstract

Background: Damage to the integrity of some body tissues due to trauma commonly referred to as injury can occur intentionally or unintentionally. Angiogenesis and fibroblast proliferation are important stages in the proliferation stage in determining the success of the wound healing process. Chitosan from haruan fish scales has active functional groups in the form of anti-inflammatory and antioxidants that are effective in accelerating wound healing. Method: This study was a pure experimental study with a post-test only design with a control group design which was divided into a treatment group and a control group. The treatment group consisted of chitosan haruan fish scales at concentrations of 1%, 3%, and 5%. The control group consisted of povidone iodine as a positive control and no treatment as a negative control. All rats were injured on the back and then euthanized on days 3, 5, 7, and 14. Result: The chitosan from haruan fish scales affected the formation of new blood vessels and fibroblasts on day-3, increase the number of new blood vessels on day-5, decrease the number of new blood vessels accompanied by increase the number of fibroblasts on day-7, and also decrease the number of fibroblasts on day-14.Conclusion:  3%, and 5% chitosan from haruan fish scale proved to be effective against angiogenesis and fibroblast proliferation in wound healing. 
Color Stability of Nanohybrid Resin Composites Immersed in Kalangkala (Litsea angulata) Leaf Extract and Non-Alcoholic Mouthwash Wardhana, Agung Satria; Ruzhanah, Huda; Dewi, Renie Kumala; Erlita, Isyana; Hamdani, Riky; Utami, Juliyatin Putri
Denta Journal Kedokteran Gigi Vol 20 No 2 (2026): August
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v20i2.5

Abstract

Background: Dental caries is commonly treated using tooth-colored restorative materials such as resin composites. However, composite resin restoration may discolor due to long term exposure of mouthwash. Newest herbal research introduces an extract of Kalangkala (Litsea angulata) leaves as a potential mouthwash derived from Kalimantan’s local plant. Kalangkala leaf extract has demonstrated antibacterial activity against oral bacteri. Kalangkala leaf also has a potential in reducing side effects from synthetic ingredients in conventional mouthwash. Objective: To analyze color stability of nanohybrid resin composite after immersion in 3% Kalangkala extract and non-alcoholic mouthwash. Materials and Methods: This experimental study used a post-test and control group design using 30 samples of resin composite using ISO 4049(2000) standardization. Group 1 was immersed in kalangkala extract, group 2 immersed in non-alcohol mouthwash, and group 3 in distilled water for 31 hours. The picture was taken with a high-resolution digital camera and lightning device for brightness standardization. Color changes were measured using MATLAB software with CIELAB color system. Data were analyzed statistically using ANOVA. Results: Although the Kalangkala extract group showed the highest mean color change, no statistically significant difference were found among the three immersion solutions (p=0.971). Conclusion: The Immersion in kalangkala leaf extract did not significantly affect the color change of nanohybrid resin composite.