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All Journal Jurnal Ilmiah Mahasiswa Pendidikan Biologi Indonesian Journal of Pharmacology and Therapy
Fitria, Humairah
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology

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FERMENTED SOLUTION (ENSILING) GREEN MUSTARD (BRASSICA JUNCEA) AS A NATURAL PRESERVATIVE OF DENCIS FISH (SARDINELLA LONGICEPS Fitria, Humairah; Safrida, Safrida; Khairil, Khairil; Rahmatan, Hafnati; Iswadi, Iswadi
Jurnal Ilmiah Mahasiswa Pendidikan Biologi Vol 5, No 1 (2020): FEBRUARI 2020
Publisher : Jurnal Ilmiah Mahasiswa Pendidikan Biologi

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Abstract

Ensiling mustard greens is a natural preservation method with a fermentation method with the aim of being a place for the development of lactic acid bacteria that can reduce pH to maintain an acidic atmosphere so that it inhibits the development of spoilage bacteria. The purpose of this study was to determine the effect of green mustard solution on the natural preservation of dencis fish and the organoleptic quality found in dencis fish. The benefit of this research is that it can provide information about the use of green mustard greens as a natural preservative of fresh dencis fish to the public. The method used in this study is an experimental method with a Completely Randomized Design (CRD) consisting of 4 treatments and 5 replications. The treatments were without immersion (P0), 1 hour immersion (P1), 3 hour immersion (P2), and 6 hour immersion (P3). Data analysis with Analysis of Variance (ANAVA) with further testing BJND at ? = 0.05. The provision of green mustard solvent solution greatly affects the organoleptic (taste, color, texture and aroma) and greatly influences the level of panelists' preference for aroma, texture and taste but does not look different in the color of fried dencis fish.Keywords: Dencis fish, mustard greens, organoleptics, ensiling. Ensiling sawi hijau merupakan metode pengawetan alami dengan metode fermentasi  dengan tujuan menjadi tempat berkembangnya bakteri asam laktat yang dapat menurunkan pH untuk mempertahankan suasana asam sehingga menghambat perkembangan bakteri pembusuk. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh larutan ensiling sawi hijau terhadap pengawetan alami ikan dencis dan mutu organoleptik yang terdapat pada ikan dencis. Manfaat dari penelitian ini yaitu dapat memberikan informasi mengenai pemanfaatan ensiling sawi hijau sebagai bahan pengawet alami ikan dencis segar kepada masyarakat. Metode yang digunakan dalam penelitian ini adalah metode eksperimental dengan Rancangan Acak Lengkap (RAL) terdiri atas 4 perlakuan dan 5 ulangan. Perlakuan tersebut adalah tanpa perendaman (P0), perendaman 1 jam (P1), perendaman 3 jam (P2), dan perendaman 6 jam (P3). Analisis data dengan Analisis Varians (ANAVA) dengan uji lanjut BJND pada ?= 0,05. Pemberian larutan ensiling sawi hijau sangat berpengaruh terhadap organoleptik (rasa, warna, tekstur dan aroma) dan sangat mempengaruhi tingkat kesukaan panelis terhadap aroma, tekstur dan rasa namun tidak terlihat berbeda pada warna ikan dencis yang telah digoreng. Kata Kunci: Ikan dencis, sawi hijau, organoleptik, ensiling.
Biomarkers improving decisions making in clinical trials: explanations and examples Faiha, Dhea Kirana; Lupitasari, Florentina Bety Indah; Fitria, Humairah; Salamah, Umi; Supriyati, Vidia Ajeng
Indonesian Journal of Pharmacology and Therapy Vol 5 No 3 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.13088

Abstract

Biomarkers are originate from physiological processes, medical imaging, tissues, or chemicals. They are potentially useful indicators for every type of disease and have important roles on drug discovery and development, disease progression tracking, prognosis, diagnosis, and therapy response. Biomarkers provide precision measurement results, lower bias result, also faster early warning signal. Therefore, they can be used as a basis for clinical decisions. Biomarkers found in tissues, blood, and other bodily fluids. Depend on their purpose of usage, biomarkers can be categorized of diagnostic, prognostic to predicts disease progression, pharmacodynamic to measures the effect of a drug on a biological system, and predictive to predicts response to a specific treatment. In clinical trials, biomarker can be used as basic of decisions making. Therefore, several steps required to incorporate biomarkers in clinical trials are determine roles and functions of biomarkers, choose specific test and laboratory according to purpose of trial, describe test and protocol, carry out and report analysis validation appropriate for trial, implement test in trial, and plan sustainability of biomarker uses in future research. Biomarker have been used as basis of decision making in clinical trials in phase I-IV to recruit participants or making a decision whether the trial will be terminated or continued. In this review, we outlined general explanations about molecular biomarkers, step of biomarkers incorporation in clinical trial, and examples of several studies using molecular biomarkers in clinical trial as basis of decision-making.
Co-Authors Faiha, Dhea Kirana Hafnati Rahmatan Iswadi Iswadi Khairil Khairil Luh Putu Ratna Sundari Lupitasari, Florentina Bety Indah Supriyati, Vidia Ajeng Umi Salamah