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All Journal Jurnal Ilmu dan Teknologi Kesehatan Jurnal Pengabdian Kesehatan Jurnal Buana Farma Borneo Journal of Pharmacy Media of Health Research
Prajawanti, Kadeq Novita
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Borneo Journal of Pharmacy

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Antidiabetic and TNF-α Lowering Effect of Tagetes erecta Extract in Alloxan-Induced Diabetic Rats Prajawanti, Kadeq Novita; Negara, Yohanes Ardian Kapri; Arianing, Intan Febiola; Junitasari, Fitri
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6871

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by impaired insulin production or action, often leading to pancreatic β-cell dysfunction and apoptosis. Pro-inflammatory cytokines, notably Tumor Necrosis Factor-alpha (TNF-α), play a critical role in the pathogenesis of type 2 diabetes (T2D). While Tagetes erecta (marigold) has demonstrated potential in lowering blood glucose in hyperglycemic conditions, its anti-inflammatory effects in diabetic models remain underexplored. This study aimed to evaluate the antidiabetic and TNF-α lowering effects of T. erecta extract in alloxan-induced diabetic rats. Twenty-five male Wistar rats were divided into a normal control group (n=5) and a diabetic group (n=20) induced by alloxan (blood glucose ≥126 mg/dL). Diabetic rats were then randomized into four treatment subgroups (n=5 each): untreated diabetic control, and diabetic groups treated with T. erecta extract at doses of 25 mg/kg BW, 50 mg/kg BW, or 75 mg/kg BW (administered intraperitoneally). Statistical analysis revealed that T. erecta extract significantly reduced blood glucose levels in alloxan-induced diabetic rats (p <0.05). Furthermore, the highest dose of T. erecta extract (75 mg/kg BW) effectively attenuated elevated TNF-α levels, demonstrating a significant anti-inflammatory effect. In conclusion, this study provides compelling evidence that T. erecta extract exhibits both antidiabetic and anti-inflammatory properties by significantly lowering blood glucose and TNF-α levels in alloxan-induced diabetic rats, particularly at the 75 mg/kg BW dose.
Co-Authors Anwari, Farida Arianing, Intan Febiola Aristia, Bella Fevi Charisma, Acivrida Mega Junitasari, Fitri Negara, Yohanes Ardi Kapri Negara, Yohanes Ardian Kapri Novia Rahmawati Nurdianto, Arif Rahman Octifani, Amellya Oktavia, Dian Ayu