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All Journal INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi YARSI Medical Journal
Nurrokhman, Nurrokhman
Unknown Affiliation
Computer Science & IT Decision Sciences, Operations Research & Management Medicine & Pharmacology

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OTOVAKSIN SEBAGAI TERAPI ALTERNATIF INFEKSI MYCOBACTERIUM TUBERCULOSIS PADA TIKUS PUTIH (RATTUS NORVEGICUS) Praseno, Praseno; Nurrokhman, Nurrokhman; Fiatiningsih, Istiana
Jurnal Kedokteran YARSI Vol 15, No 3 (2007): SEPTEMBER-DESEMBER 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v15i3.1077

Abstract

Tuberculosis (TB) is still an important public health problem, especially in developing countries such as Indonesia. Efforts have been made to overcome the problem, however, number of cases is still high. This is due to various factors which might affect the development of the disease. Increasing number of resistant strains against antimycobacterial drugs is one of the major factors. Therefore, alternative method to control TB is needed.The aim of this study was to evaluate the effectiveness of autogenous vaccine on healing process of infection caused by Mycobacterium tuberculosis in rats. Eighteen Wistar rats (Rattus norvegicus) were infected with 109 colony forming unit of M. tuberculosis subcutaneously. One week after infection, the rats were divided randomly into 2 groups, first group were treated with autogenous vaccine and the other were left untreated (control group). Autogenous vaccine was given subcutaneously with the dose of 108 cfu/0,1 ml every 7 days 3 times. Subcutaneous nodules were evaluated every 3 days and weight gain was evaluated 3 times. Laboratory examinations were done, including acid fast bacilli stain, histopatological feature and serologic test. The result showed that recovery of subcutaneous nodules in autovaccine treated group of rats was faster than that of untreated control group. Acid fast bacilli staining showed that the number of micobacteria found in the lung, liver, spleen and kidney of autovaccine treated group were much lower than those found in the control group. Histopathology features showed that lymphocytes infiltration in the lung and other organs was heavier in the control group than that of treated group. In conclusion, animal study on rats showed that autogenous vaccine had effective therapeutic effect on healing process for M. tuberculosis infection.   
Utilization of Social Network Analysis (SNA) in Knowledge Sharing in College Nurrokhman, Nurrokhman; Dwi Purnomo, Hindriyanto; Dwi Hartomo, Kristoko
INTENSIF: Jurnal Ilmiah Penelitian dan Penerapan Teknologi Sistem Informasi Vol 4 No 2 (2020): August 2020
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (709.035 KB) | DOI: 10.29407/intensif.v4i2.14460

Abstract

Campus competition in Central Java creates superior and empowered human resources to make XYZ campus optimize the Knowledge Sharing process. In optimizing the Knowledge Sharing process on the XYZ campus through interaction and communication between students in the study program. This study aims to identify the Knowledge Sharing collaboration of students on the XYZ campus in three study programs with 100 respondents using the Social Network Analysis (SNA) method. The parameters used in this study include density, degree centrality, closeness centrality, betweenness centrality, and clicks (subgroups). Based on the analysis of the results obtained by the level of density level of 4.7% or weak ties because under 50%. Actor 98 has the highest degree of centrality with outdegree value 32 and indegree 7, while actor 65, which has the highest closeness centrality with inCloseness value 16,952 and outCloseness value 1,020. Actor 15 also has the highest centrality betweenness with an amount of Betweenness 2750,148 and nBetweenness 28,346. In this study, it can be concluded that there is collaboration in the Knowledge Sharing of students on the XYZ campus from each divided into three study programs, namely, informatics engineering, accounting computerization, and graphic design.
Co-Authors Fiatiningsih, Istiana Hindriyanto Dwi Purnomo Kristoko Dwi Hartomo Praseno Praseno