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All Journal Jurnal Kesehatan Terpadu (Integrated Health Journal) Media Gizi Kesmas Media Kesehatan Politeknik Kesehatan Makassar Poltekita: Jurnal Ilmu Kesehatan
Zurimi, Suardi
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Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Efek Asupan Antioksidan Kaya Enzim Cytochrome P450 2E1 (CYP2E1) Terhadap Kadar Leukosit M. Subandi, Baharuddin; Zurimi, Suardi; Rohim Tualeka, Abdul; Bella Puspitaloka, Nanda
Media Kesehatan Politeknik Kesehatan Makassar Vol 19 No 2 (2024): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v19i2.1051

Abstract

The human body has an enzymatic antioxidant system, but its capacity is not always sufficient when the amount of free radicals is excessive. The approach of consuming antioxidants rich in the CYP2E1 enzyme is used to help the body detoxify benzene metabolites so they can be excreted from the body. The aim of this study is to analyze the effect of consuming antioxidants rich in the CYP2E1 enzyme on changes in leukocyte levels among workers in the Tambak Osowilangun Surabaya home-based shoe industry. This type of research is a pre-experimental study using a one-group pre-test post-test design. The sample used in this study was total population sampling, consisting of all 27 workers in the Tambak Osowilangun home-based shoe industry. The intervention provided was in the form of antioxidant supplements in powder form, with a dosage of 15 grams, consumed twice a day for 5 consecutive days. Leukocyte levels were measured by taking blood samples from the workers on the first day before the intervention and on the fifth day after the intervention. The results of the study showed changes in the leukocyte levels of all workers after the treatment. There was an increase in the number of workers who reached normal leukocyte levels (92.6%). However, some workers did not reach normal leukocyte levels (7.4%) despite experiencing changes in their leukocyte levels. The conclusion of this study is that the intervention was effective in normalizing the workers' leukocyte levels, particularly in female workers, those of productive age, with normal BMI, non-smokers, those who engage in physical activity/exercise, and those who do not use personal protective equipment (PPE). It is recommended that workers regularly engage in exercise that suits their preferences and body needs, adopt a balanced diet, consume foods rich in antioxidants, use brushes when applying glue, and use standard PPE such as N95 masks, gloves, and aprons..  Keywords: leukocyte count; antioxidant; CYP2E1
Impact of Coconut Water (Cocos Nucifera L) on Total Cholesterol Levels of Patients with Hypercholesterol Djafar, Ida Ida; Zurimi, Suardi; Rasako, Hairudin; Nendissa, Mintje Maria
Jurnal Kesehatan Terpadu (Integrated Health Journal) Vol 16 No 1 (2025): Jurnal Kesehatan Terpadu (Integrated Health Journal)
Publisher : Poltekkes Kemenkes Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32695/jkt.v16i1.670

Abstract

High levels of cholesterol in the blood increase the risk of atherosclerosis resulting in lipid plaque formation, especially with increased levels of low-density lipoprotein (LDL-C). This study was conducted to determine the impact of coconut water (Cocos nucifera L.) on total cholesterol levels of hypercholesterolemia patients. This type of research is a quasi-experiment. The design used is one group pretest-posttest design, which is research using the same group. Measurements were taken twice before the intervention and after the intervention. The research was conducted in the working area of the Hative Kecil Health Center, Ambon City in September - November 2024. The number of samples was 6 respondents. The pretest research variable shows the mean value obtained is 220.5 mg/dl, the maximum value is 243 mg/dl, the minimum value is 206 and the std. deviation value is 14.7. The posttest variable shows the mean value obtained of 203.8 mg/dl, the maximum value of 238 mg/dl, the minimum value of 183 mg/dl and the std. deviation value of 20.1. The results of the Paired t-Test test, it is known that the significance number shows a value of p = 0.003 < α = 0.05, which means that there is an effect of giving young coconut water (cocos nucifera l.) on total cholesterol levels. Keywords: total cholesterol; cocos nucifera L.water
Systematic Review: Impact of Air Pollution on DNA Methylation Akbar, Muhammad Ihzario Ibrahim; Tualeka, Abdul Rohim; Zurimi, Suardi; Jalaludin, Juliana
Media Gizi Kesmas Vol 14 No 1 (2025): MEDIA GIZI KESMAS (JUNE 2025)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgk.v14i1.2025.165-175

Abstract

Background: Quality of life is an important. It is influenced by exposure to chemicals in the body, such as air pollution, which can damage supporting life in the future. Objective: The aim of writing this systematic review is to specify the impact of air pollution on DNA methylation. Methods: The method in this study uses the Preferred Reporting Items for Systematic Review and Meta-analyses, this methode is carried out by searching for data in the form of articles or journals, which is carried out using the keywords "Air pollution" and "DNA methylation". Overall data from articles or jurnals based on searches using the keywords "Air pollution" and "DNA Methylation" (n=25), data from articles or journals focused on this research and articles or journals that can be accessed for free with the year publication year in the last 10 years (n=20), after which they are adjusted to the inclusion criteria of this study (n=15). Result: In this study, the results of the systematic review were obtained that this long-term impact will affect a person's quality of life, apart from that, it can also cause serious complications such as repeated respiratory infections, which can lead to decreased lung function and a higher risk of death. Conclusion: DNA is a logical tool for understanding the impact of air pollution on genome function and downstream activities that benefit health.
Gambaran Pengetahuan Dan Sikap Ibu Tentang Kesiapan Toilet Training Pada Balita Di WIlayah Kerja Puskesmas Belakang Soya Kecamatan Sirimau Kota Ambon Zurimi, Suardi; Tomasoa, Johanna; Nendissa, Mintje Maria; Rasako, Hairudin
Jurnal Kesehatan Terpadu (Integrated Health Journal) Vol 16 No 2 (2025): Jurnal Kesehatan Terpadu (Integrated Health Journal)
Publisher : Poltekkes Kemenkes Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32695/jkt.v16i2.730

Abstract

Toilet Training pada anak merupakan suatu usaha untuk melatih anak agar mampu mengontrol dalam melakukan buang air besar dan buang air kecil. Toilet Training ini dapat berlangsung pada kehidupan balita. dalam melakukan buang air besar dan buang air kecil pada ibu balita membutuhkan persiapan baik secara fisik, psikologis maupun secara intelektual. Penulisan ini bertujuan untuk mengetahui Gambaran Pengetahuan dan Sikap Ibu Tentang Kesiapan Toilet Training pada Ibu Balita di Wilayah Kerja Puskesmas Waihoka Kecamatan Sirimau Kota Ambon. Rancangan penulisan yang digunakan adalah cross sectional, yaitu rancangan penulisan dengan cara mengukur variabel bebas dan variabel terikat dalam waktu yang bersamaan (menggunakan kuesioner). Jumlah sampel dalam penulisan ini adalah sebanyak 40 responden yang diambil secara Total sampling. Hasil penulisan diuji dengan menggunakan uji statistik Chi square dengan tingkat kesalahan ????=0.05 dan didapatkan gambaran bermakna antara pengetahuan dengan kesiapan toilet training dan ada gambaran antara sikap dengan kesiapan toilet training dengan demikian dapat disimpulkan bahwa ada gambaran pengetahuan dan sikap ibu tentang kesiapan toilet training pada ibu balita di wilayah kerja Puskesmas Waihoka Kecamatan Sirimau Kota Ambon. Keywords: Knowledge, Attitude, Readiness for Toilet Training
Toluene Exposure Concentration and Neurotoxic Risk Quotient among Industrial Workers in Surabaya: A Cross-Sectional Study Zurimi, Suardi; Tualeka, Abdul Rohim
Poltekita: Jurnal Ilmu Kesehatan Vol. 19 No. 3 (2025)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v19i3.4213

Abstract

Background: Toluene poses significant health hazards to humans. Occupational exposure among workers who use toluene as a solvent may lead to various adverse health effects, including dizziness, vertigo, ocular and skin irritation, respiratory disturbances, as well as disorders of the liver, kidneys, and central nervous system. This study aimed to examine the association between toluene concentration and non-carcinogenic risk characteristics with neurotoxic effects across five industrial settings in the Surabaya region. Methods: This observational study employed a cross-sectional design and was conducted in five industries in Surabaya that utilize toluene as a solvent in their production processes, located in Osowilangun, Ketintang, Jemursari, Kalijudan, and AUP Which will be implemented in 2025. The study population consisted of 90 workers exposed to toluene, of whom 77 participants were selected using an accidental sampling technique. The variables examined included toluene concentration, toluene risk quotient (RQ), and neurotoxic effects. Results: Overall, 50 workers (65%) had unsafe risk quotient (RQ) levels, and 48 workers (62.3%) experienced neurotoxic effects. Although the majority of workers (52.0%) were exposed to toluene concentrations below the threshold limit value, those exposed to concentrations above the threshold had a 1.38-fold higher risk of neurotoxic effects, and workers with unsafe RQ had a 1.4-fold increased risk compared with those with safe RQ. Statistical analysis showed no significant association between toluene concentration or RQ and neurotoxic effects (p > 0.05). Conclusion: Although not statistically significant, the study suggests that the Risk Quotient (RQ) of toluene is a key determinant of neurotoxic risk, highlighting the importance of monitoring and controlling exposure in the workplace.
Co-Authors Abdul Rohim Tualeka Akbar, Muhammad Ihzario Ibrahim Bella Puspitaloka, Nanda Djafar, Ida Ida Jalaludin, Juliana M. Subandi, Baharuddin Nendissa, Mintje Maria Rasako, Hairudin Tomasoa, Johanna