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All Journal Jurnal Kesehatan Terpadu (Integrated Health Journal) Media Gizi Kesmas Media Kesehatan Politeknik Kesehatan Makassar
Zurimi, Suardi
Unknown Affiliation
Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Efek Asupan Antioksidan Kaya Enzim Cytochrome P450 2E1 (CYP2E1) Terhadap Kadar Leukosit M. Subandi, Baharuddin; Zurimi, Suardi; Rohim Tualeka, Abdul; Bella Puspitaloka, Nanda
Media Kesehatan Politeknik Kesehatan Makassar Vol 19 No 2 (2024): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v19i2.1051

Abstract

The human body has an enzymatic antioxidant system, but its capacity is not always sufficient when the amount of free radicals is excessive. The approach of consuming antioxidants rich in the CYP2E1 enzyme is used to help the body detoxify benzene metabolites so they can be excreted from the body. The aim of this study is to analyze the effect of consuming antioxidants rich in the CYP2E1 enzyme on changes in leukocyte levels among workers in the Tambak Osowilangun Surabaya home-based shoe industry. This type of research is a pre-experimental study using a one-group pre-test post-test design. The sample used in this study was total population sampling, consisting of all 27 workers in the Tambak Osowilangun home-based shoe industry. The intervention provided was in the form of antioxidant supplements in powder form, with a dosage of 15 grams, consumed twice a day for 5 consecutive days. Leukocyte levels were measured by taking blood samples from the workers on the first day before the intervention and on the fifth day after the intervention. The results of the study showed changes in the leukocyte levels of all workers after the treatment. There was an increase in the number of workers who reached normal leukocyte levels (92.6%). However, some workers did not reach normal leukocyte levels (7.4%) despite experiencing changes in their leukocyte levels. The conclusion of this study is that the intervention was effective in normalizing the workers' leukocyte levels, particularly in female workers, those of productive age, with normal BMI, non-smokers, those who engage in physical activity/exercise, and those who do not use personal protective equipment (PPE). It is recommended that workers regularly engage in exercise that suits their preferences and body needs, adopt a balanced diet, consume foods rich in antioxidants, use brushes when applying glue, and use standard PPE such as N95 masks, gloves, and aprons..  Keywords: leukocyte count; antioxidant; CYP2E1
Impact of Coconut Water (Cocos Nucifera L) on Total Cholesterol Levels of Patients with Hypercholesterol Djafar, Ida Ida; Zurimi, Suardi; Rasako, Hairudin; Nendissa, Mintje Maria
Jurnal Kesehatan Terpadu (Integrated Health Journal) Vol 16 No 1 (2025): Jurnal Kesehatan Terpadu (Integrated Health Journal)
Publisher : Poltekkes Kemenkes Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32695/jkt.v16i1.670

Abstract

High levels of cholesterol in the blood increase the risk of atherosclerosis resulting in lipid plaque formation, especially with increased levels of low-density lipoprotein (LDL-C). This study was conducted to determine the impact of coconut water (Cocos nucifera L.) on total cholesterol levels of hypercholesterolemia patients. This type of research is a quasi-experiment. The design used is one group pretest-posttest design, which is research using the same group. Measurements were taken twice before the intervention and after the intervention. The research was conducted in the working area of the Hative Kecil Health Center, Ambon City in September - November 2024. The number of samples was 6 respondents. The pretest research variable shows the mean value obtained is 220.5 mg/dl, the maximum value is 243 mg/dl, the minimum value is 206 and the std. deviation value is 14.7. The posttest variable shows the mean value obtained of 203.8 mg/dl, the maximum value of 238 mg/dl, the minimum value of 183 mg/dl and the std. deviation value of 20.1. The results of the Paired t-Test test, it is known that the significance number shows a value of p = 0.003 < α = 0.05, which means that there is an effect of giving young coconut water (cocos nucifera l.) on total cholesterol levels. Keywords: total cholesterol; cocos nucifera L.water
Systematic Review: Impact of Air Pollution on DNA Methylation Akbar, Muhammad Ihzario Ibrahim; Tualeka, Abdul Rohim; Zurimi, Suardi; Jalaludin, Juliana
Media Gizi Kesmas Vol 14 No 1 (2025): MEDIA GIZI KESMAS (JUNE 2025)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgk.v14i1.2025.165-175

Abstract

Background: Quality of life is an important. It is influenced by exposure to chemicals in the body, such as air pollution, which can damage supporting life in the future. Objective: The aim of writing this systematic review is to specify the impact of air pollution on DNA methylation. Methods: The method in this study uses the Preferred Reporting Items for Systematic Review and Meta-analyses, this methode is carried out by searching for data in the form of articles or journals, which is carried out using the keywords "Air pollution" and "DNA methylation". Overall data from articles or jurnals based on searches using the keywords "Air pollution" and "DNA Methylation" (n=25), data from articles or journals focused on this research and articles or journals that can be accessed for free with the year publication year in the last 10 years (n=20), after which they are adjusted to the inclusion criteria of this study (n=15). Result: In this study, the results of the systematic review were obtained that this long-term impact will affect a person's quality of life, apart from that, it can also cause serious complications such as repeated respiratory infections, which can lead to decreased lung function and a higher risk of death. Conclusion: DNA is a logical tool for understanding the impact of air pollution on genome function and downstream activities that benefit health.
Co-Authors Abdul Rohim Tualeka Akbar, Muhammad Ihzario Ibrahim Bella Puspitaloka, Nanda Djafar, Ida Ida Jalaludin, Juliana M. Subandi, Baharuddin Nendissa, Mintje Maria Rasako, Hairudin