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Uji Antibakteri Ekstrak Daun Lantana camara L. terhadap Staphylococcus epidermidis, Staphylococcus aureus, dan Escherichia coli Sari, Melia; Diana, Vivi Eulis; Hidayah, Yusriah
Journal of Islamic Pharmacy Vol 8, No 1 (2023): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v8i1.17308

Tembelekan disebut Lantana camara L. atau Lantana aculeata L. termasuk kedalam famili tumbuhan Verbenaceae. Tanaman ini dikenal dengan nama daerah bunga pagar, kayu singapur dan teterapan merupakan jenis tumbuhan yang banyak dimanfaatkan oleh masyarakat secara tradisional sebagai obat luka, bisul, peluruh air seni, batuk, peluruh keringat, dan penurun panas. Tanaman ini tumbuh liar dan memiliki metabolit sekunder yang beragam, khususnya pada bagian daun, seperti senyawa terpenoid yang termasuk senyawa atsiri, flavonoid, fenol, saponin, alkaloid, steroid, tanin, dan quinon. Penelitian ini bertujuan untuk melihat efek penggunaan ekstrak daun tembelekan (Lantana camara L.) dengan konsentrasi 3%, 6%, 9% dapat menghambat pertumbuhan bakteri Staphylococcus aureus, Staphylococcus epidermidis, dan Escherichia coli. Jenis penelitian yang digunakan yaitu penelitian eksperimental laboratorium, meliputi penyiapan sampel, pembuatan ekstrak, uji skrining fitokimia, dan pengujian aktivitas antibakteri. Hasil penelitian menunjukkan ekstrak etanol daun tembelekan mengandung senyawa flavonoid, alkaloid, saponin, dan tanin sehingga memiliki potensi antibakteri terhadap S. aureus dengan konsentrasi 9% sebesar 17,06±0,24 mm, S. epidermidis dengan konsentrasi 9% sebesar 17,53±0,22 mm sedangkan E. coli dengan konsentrasi 9% sebesar 16,9±0,08 mm. Kategori zona hambat yang terbentuk adalah kuat, sedangkan kontrol positif memiliki kategori sangat kuat dengan rata-rata zona hambat ketiga bakteri yaitu S. aureus 24,5 mm, S. epidermidis 24,95 mm, dan E. coli 23,65 mm.

Formulation of Mouth Mouth From Ethanol Extract of Carrot (Daucus Carota L.) Tubes as an Antifungal Against The Growth of Candida Albicans Diana, Vivi Eulis; Abadi, Hafizhatul
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.633

One of the causes of canker sores and bad breath is the presence of fungus in the oral cavity. This can be overcome by gargling using mouthwash. Research has been carried out on the formulation of mouthwash preparations from ethanol extract of carrot (Daucus carota L.) tubers as an antifungal against the growth of Candida albicans. Objectives: The aim of this study was to see the antifungal activity of carrot tuber extract mouthwash preparations. Methods: This research is a type of laboratory experimental research using the paper disc diffusion method on agar media to see the antifungal activity of carrot root extract mouthwash preparations. Carrot tuber extract mouthwash was made into four formulas, namely F0 (preparation without extract), F1 (5% carrot extract), F2 (15% carrot extract) and F3 (30% carrot extract). Evaluation of mouthwash preparations includes examination of organoleptic, pH, viscosity and stability. Results: indicate that mouthwash preparations can provide antifungal activity against the growth of Candida albicans. The diameter of the inhibition zone obtained at concentrations of 5% (2.9 mm), 15% (3.9 mm) and 30% (5.3 mm). All mouthwash formulations have a weak category of inhibitory power. The results of organoleptic evaluation, pH, viscosity and stability of mouthwash preparations gave good results, were stable and fulfilled the requirements for mouthwash preparations. Conclusion is that the ethanol extract of carrot root can be formulated into mouthwash and has weak antifungal activity.

Formulation of Mouth Mouth From Ethanol Extract of Carrot (Daucus Carota L.) Tubes as an Antifungal Against The Growth of Candida Albicans Diana, Vivi Eulis; Abadi, Hafizhatul
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.633

One of the causes of canker sores and bad breath is the presence of fungus in the oral cavity. This can be overcome by gargling using mouthwash. Research has been carried out on the formulation of mouthwash preparations from ethanol extract of carrot (Daucus carota L.) tubers as an antifungal against the growth of Candida albicans. Objectives: The aim of this study was to see the antifungal activity of carrot tuber extract mouthwash preparations. Methods: This research is a type of laboratory experimental research using the paper disc diffusion method on agar media to see the antifungal activity of carrot root extract mouthwash preparations. Carrot tuber extract mouthwash was made into four formulas, namely F0 (preparation without extract), F1 (5% carrot extract), F2 (15% carrot extract) and F3 (30% carrot extract). Evaluation of mouthwash preparations includes examination of organoleptic, pH, viscosity and stability. Results: indicate that mouthwash preparations can provide antifungal activity against the growth of Candida albicans. The diameter of the inhibition zone obtained at concentrations of 5% (2.9 mm), 15% (3.9 mm) and 30% (5.3 mm). All mouthwash formulations have a weak category of inhibitory power. The results of organoleptic evaluation, pH, viscosity and stability of mouthwash preparations gave good results, were stable and fulfilled the requirements for mouthwash preparations. Conclusion is that the ethanol extract of carrot root can be formulated into mouthwash and has weak antifungal activity.

Analisis Kepuasan Pasien Rawat Inap Kelas III Terhadap Mutu Pelayanan Kesehatan di Rumah Sakit Umum Daerah Simeulue Kabupaten Simeulue Aprinaldi, Aprinaldi; Nyorong, Mappeaty; Diana, Vivi Eulis
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 8, No 2 (2022): OKTOBER 2022
Publisher : Universitas Ubudiyah Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33143/jhtm.v8i2.2398

Perkembangan manajemen mutu di bidang pelayanan kesehatan khususnya pelayanan rumah sakit umum daerah simeulue masih dirasakan kurang. Penelitian bertujuan mengetahui tingkat mutu pelayanan yang dilihat berdasarkan tingkat kesesuaian nilai harapan dan nilai kenyataan terhadap kepuasan pasien yang ditinjau dari dimensi kenyataan (tangible), kehandalan (reliability), ketanggapan (responsiveness), jaminan (ansurance), dan empati (emphaty) yang dilaksanakan di ruang rawat inap kelas III RSUD Simeulue Kabupaten Simeulue Tahun 2020.Â Â Â Penelitian ini deskriptif analitik dengan desain cross sectional. Pengumpulan data dilakukan dengan wawancara menggunakan kuesioner. Populasi seluruh pasien dirawat diruang penyakit dalam, ruang obgyn dan ruang bedah RSUD Simeulue Kabupaten Simeulue. sampel 91 responden dengan menggunakan teknik proportional random sampling. Metode analisis kenyataan dan harapan/ importance performance analisis.Hasil penelitian diperoleh bahwa kualitas pelayanan kenyataan terhadap kepuasan pasien rawat inap (86,15%), Kualitas pelayanan kehandalan terhadap kepuasan pasien rawat inap (92,05%), Kualitas pelayanan ketanggapan terhadap kepuasan pasien rawat inap (92,50%),kualitas pelayanan jaminan terhadap kepuasan pasien rawat inap (86,15%),kualitas pelayanan empati terhadap kepuasan pasien rawat inap (91,52%) dan rata-rata pelayanan terhadap kepuasan pasien rawat inap (89,87%). Dengan demikian mutu pelayanan dan kepuasan pasien rawat inap masih dibawah 100%. Melalui kepala RSUD Simeulue diharapkan kepada petugas kesehatan untuk memberikan pelayanan kepada pasien rawat inap dengan sebaik-baiknya dari dan memeriksa kembali sarana dalam pelayanan rawat inap.Kata Kunci : Mutu pelayanan, harapan dan kenyataan, pasien rawat inapThe development of quality management in the field of health services, especially the services of the Simeulue regional general hospital, is still lacking. This study aims to determine the level of service quality which is seen based on the level of conformity of the expected value and the reality value to patient satisfaction in terms of the dimensions of reality (tangible), reliability, responsiveness, assurance, and empathy. in the class III inpatient room at the Simeulue Hospital, Simeulue Regency in 2020.This research was descriptive analytic with cross-sectional design. Data collection was done by interview using a questionnaire. The entire population of patients treated in internal medicine, space obgyn and surgery hospital of Regency. The sample were taken 91 respondents using proportional random sampling technique. The method of analysis of reality and hope/importance performance analysis.The results showed that the quality of service in reality on inpatient satisfaction (86.15%), quality of service reliability on inpatient satisfaction (92.05%), service quality responsiveness to inpatient satisfaction (92.50%), quality of service guarantee service to inpatient satisfaction (86.15%), the quality of empathy service to inpatient satisfaction (91.52%) and the average service to inpatient satisfaction (89.87%). Thus the quality of service and satisfaction of inpatients was still below 100%.Through the head of the Simeulue Hospital, it is hoped that health workers will provide services to inpatients as well as possible from and re-examine the facilities in inpatient services.Keywords: Quality of service, expectations and reality, inpatients

Difference in Effectiveness Gel Dosage form Green Papaya (Carica papaya L.) Skin Ethanol Extract and Gel Dosage form Green Papaya Seed Against Cutibacterium acnes Bacteria Diana, Vivi Eulis; Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9330

Many things can cause acne, including stress, fatty foods, inappropriate or unsuitable makeup, and pollution. Cosmetics made from plants are safer to use. Papaya skin and seeds (Carica papaya L.) have antibacterial properties in the form of alkaloids, tannins, steroids, saponins, and flavonoids. This study aims to determine the comparison of the antibacterial power of young papaya skin ethanol extract gel and young papaya seed ethanol extract gel against Cutibacterium acnes bacteria. The research method is experimental with various formulas consisting of F0 (0%), F1 (11%), F2 (12%), and F3 (13%). The results of the study obtained antibacterial gel preparations from the three concentrations showed that the organoleptic test of the young papaya fruit skin ethanol extract gel preparation was light brown, blackish brown, dark blackish brown. The homogeneity test was homogeneous. The pH test was 5.9, 6.5, 7.0, and the seed ethanol extract gel preparation was light brown, dark brown, thick dark brown. The homogeneity test was homogeneous. Test pH 5.0, 5.6, 5.5, 5.1. The conclusion of this study is that the antibacterial effectiveness of young papaya fruit skin ethanol extract gel is greater than young papaya fruit seed ethanol extract gel at a concentration of 13% against Cutibacterium acnes bacteria.

Formulation and release testing of mecobalamin in gelatin capsule derived from striped Snakehead (Channa striata) Sari, Mayang; Diana, Vivi Eulis; Siahaan, Azmialamsyah Putra
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.30001

Capsules are medicinal preparations wrapped in hard or soft capsule shells. The material for making capsule shells is gelatin obtained from partial hydrolysis of animal skin or bones. One source of gelatin that can be used as a basic material for forming capsule shells is snakehead fish skin. This study aimed to produce capsule shells from snakehead skin, varying the gelatin concentration in the capsule shells, and to assess the drug release properties. The evaluation of the capsule shells included measurements of length, diameter, thickness, weight, volume, disintegration time, swelling degree, and mecobalamin release using a dissolution apparatus in a simulated gastric fluid medium, with mecobalamin levels measured by UV spectrophotometry. The results showed that the snakehead capsule displayed good physical properties. The best swelling degree was observed in formula 2, with a value of 24.59%, which is close to the 27.58% swelling degree of commercial capsules (mecobalamin) at the 10-min. The mecobalamin release test indicated that the capsules from formula 2 released 30.40% of the drug at the 30-min when tested at 278 nm, compared to 33.50% from commercial capsules. Testing at a wavelength of 352 nm for formula 2 was 29.25% compared to commercial mecobalamin capsules at 34.67%. These findings highlight the promising utility of gelatin from snakehead skin in the formulation of effective drug delivery systems.

Formulation and Effectiveness Test of Liquid Soap from Siam Weed (Chromolaena odorata (L.) Leaves Ethanol Extract Against Staphylococcus aureus Diana, Vivi Eulis; Abadi, Hafizhatul; Andry, Muhammad
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7981

Chromolaena odorata (L.) is one of the plants known as weeds. Alkaloids, flavonoids, saponins, tannins, and glycosides are active chemicals found in Siam weed leaves. The study aimed to see if an ethanol extract of Siam weed leaves can be made into liquid soap and has antibacterial action against Staphylococcus aureus germs. The liquid soap of Siam weed (Chromolaena odorata L.) leaf ethanol extract at concentrations of 3%, 6%, and 9% was carried out experimentally in the laboratory, along with physical liquid soap evaluation tests such as organoleptic test, homogeneity test, pH test, foam height test, specific gravity test, test irritation, and hedonic test. Staphylococcus aureus bacteria were then tested. The assessment test criteria were met by making liquid soap preparations of ethanol extract of Siam weed leaves at concentrations of 3%, 6%, and 9%. The color of the solid soap was brown - dark brown, and the texture was liquid with a lemon scent; the homogeneity test showed that all preparations were homogeneous; the pH test of the soap was 9.1 -9.7; the foam height test was 53-66 mm; the specific gravity test was 1-1.01 g/ml; and the irritation test revealed that all preparations had no reaction to redness, itching, and swelling on the skin. The hedonic test on skin revealed that all preparations obtained favorable evaluations from the panelists. The antibacterial activity of liquid soap against Staphylococcus aureus germs was F1 3.65 mm, F2 5.75mm, and F3 6.5mm. Based on the results of the Staphylococcus aureus test, it could be concluded that in the formula F1 (3% concentration), F2 (6% concentration) and F3 (9% concentration) had an inhibition zone.

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