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All Journal Jurnal Biologi Tropis Jurnal Prima Medika Sains Journal of Pharmaceutical and Sciences.
Rumanti, Ruth Mayana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Uji antibakteri gel hand sanitizer ekstrak etanol bunga krisan (Chrysanthemum segetum) terhadap bakteri Staphylococcus aureus Rumanti, Ruth Mayana; Nasution, Rizka Hasmi; Naldi, Jefri
Jurnal Prima Medika Sains Vol. 5 No. 1 (2023): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i1.3595

Abstract

Gel hand sanitizer memiliki kemampuan aktivitas bakteriosida yang baik terhadap bakteri dikulit. Adanya kandungan senyawa flavonoida dalam bunga krisan (Chrysanthemum segetum) berperan sebagai antibakteri aktif dalam menghambat pertumbuhan bakteri Staphylococcus aureus. Studi ini bertujuan untuk menguji aktivitas antibakteri sediaan gel antiseptik tangan (hand sanitizer) ekstrak etanol bunga krisan terhadap bakteri Staphylococcus aureus. Prosedur meliputi pengumpulan, pembuatan simplisia, karakterisasi simplisia, pembuatan ekstrak dengan metode maserasi, sediaan gel dibuat menjadi konsentrasi 10%, 15% dan 20% dilanjutkan pengujian antibakteri metode difusi agar. Hasil uji zona hambat  bakteri pada konsentrasi 10% dengan nilai rata-rata 3,76 mm, konsentrasi 15% sebesar 4,71 mm dan konsentrasi 20% sebesar 5,31 mm dengan kategori sedang.
Difference in Effectiveness Gel Dosage form Green Papaya (Carica papaya L.) Skin Ethanol Extract and Gel Dosage form Green Papaya Seed Against Cutibacterium acnes Bacteria Diana, Vivi Eulis; Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.9330

Abstract

Many things can cause acne, including stress, fatty foods, inappropriate or unsuitable makeup, and pollution. Cosmetics made from plants are safer to use. Papaya skin and seeds (Carica papaya L.) have antibacterial properties in the form of alkaloids, tannins, steroids, saponins, and flavonoids. This study aims to determine the comparison of the antibacterial power of young papaya skin ethanol extract gel and young papaya seed ethanol extract gel against Cutibacterium acnes bacteria. The research method is experimental with various formulas consisting of F0 (0%), F1 (11%), F2 (12%), and F3 (13%). The results of the study obtained antibacterial gel preparations from the three concentrations showed that the organoleptic test of the young papaya fruit skin ethanol extract gel preparation was light brown, blackish brown, dark blackish brown. The homogeneity test was homogeneous. The pH test was 5.9, 6.5, 7.0, and the seed ethanol extract gel preparation was light brown, dark brown, thick dark brown. The homogeneity test was homogeneous. Test pH 5.0, 5.6, 5.5, 5.1. The conclusion of this study is that the antibacterial effectiveness of young papaya fruit skin ethanol extract gel is greater than young papaya fruit seed ethanol extract gel at a concentration of 13% against Cutibacterium acnes bacteria.
Isolasi senyawa flavonoid dari daun bakung (Crinum asiaticum L.) Abadi, Hafizhatul; Rumanti, Ruth Mayana; Andry, Muhammad; Nasution, Muhammad Amin
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.322

Abstract

Introduction Sprains and fractured bones are treated with spider lily leaves (Crinum asiaticum L.). Alkaloids, flavonoids, tannins, steroids, and triterpenoids are among the chemical components found in spider lily leaves. The most significant phytochemicals in plants with wide biological advantages for humans are bioactive flavonoids. The purpose of: The study aimed to isolate flavonoid components from spider lily leaves. Methods: This study was descriptive, using the following steps: plant material collection and preparation, sample processing, simplicia characterization, extract preparation, phytochemical screening, hydrolysis, fractionation, analysis using paper chromatography (KKt), and compound isolation using preparative paper chromatography. The isolates were tested for purity using one-way and two-way KKt, and they were identified using UV-Vis spectrophotometry with a shear reagent. The results: The results of the characterization showed that the water content was 7.21%, the water-soluble extract was 11.21%, the ethanol-soluble extract was 9.23%, the total ash content was 1.99%, and the acid-insoluble ash content was 0.81%. The screening findings indicated the presence of flavonoid chemicals. The KKt analysis results revealed that the best mobile phase was 5% acetic acid with ammonia vapor specks, and the preparative KKt isolation results yielded a single blue isolate, which was then identified by UV-Vis spectrophotometry using a shear reagent, resulting in maximum wavelength absorption (max) at band II of 253nm, presumably identifying the isoflavone group of flavonoids. Conclusion: The conclusion showed the ethyl acetate fraction of spider lily leaves could be separated using paper chromatography and that identification by spectrophotometry UV-Vis using a shear reagent wasolate, which was assumed to be an isoflavone group component.
Formulasi sediaan lip cream ekstrak etanol bunga kecombrang (Etlingera elatior (Jack) R. M. Sm.) dan bunga rosella (Hibiscus sabdariffa L.) sebagai zat pewarna alami Rumanti, Ruth Mayana; Sari , Rika Puspita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.744

Abstract

Introduction: The kecombrang flower and roselle flower are known as sources of natural antioxidants and have the potential to be used as natural dyes in lip cream products. Both types of flowers contain compounds such as tannins, flavonoids, and saponins. The aims of study to analyze the effect of varying concentrations of ethanol extract from the kecombrang flower (Etlingera elatior (Jack) R. M. Sm.) and the roselle flower (Hibiscus sabdariffa L.) on the color of lip cream formulations. The method of research was conducted through laboratory experiments that included sampling, extract preparation, product formulation, physical quality evaluation, and panelist preference testing. Data were analyzed descriptively by calculating the percentage of preference levels and presented in the form of tables and graphs. The results show that the preparation has a semi-solid texture, with colors ranging from light pink to dark pink in certain combinations, and a purplish pink for the 10% roselle extract formulation. The pH of the preparation is in the range of 5.1-5.4, without coarse grains, good spreadability, an average spread distance of 5.5 cm, an average adhesion time of 12.73 seconds, and no irritation. The cycling test indicates color instability, changing from light pink to dark brownish purple. Based on the hedonic test, formulation F5 has the highest preference level, which is 88.33%. The conclusion of this study is that the ethanol extract of kecombrang and rosella flowers produces a light pink lip cream that is suitable for formulation in lip cream preparations. The higher the concentration of the extract used, the darker the pink color produced, with a texture that tends to be more liquid and a decreasing pH.
Co-Authors Abadi, Hafizhatul Diana, Vivi Eulis Muhammad Amin Nasution Muhammad Andry Naldi, Jefri Rizka Hasmi Nasution Sari , Rika Puspita