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All Journal Pharmasipha Reka Buana : Jurnal Ilmiah Teknik Sipil dan Teknik Kimia Sasambo Journal of Pharmacy
Julianti, Andi Ika
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Public Health

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Effect of extraction method on total phenolic content and antioxidant activity of Terminalia catappa (L.) leaves Akmal, Tubagus; Julianti, Andi Ika; Tanjung, Yenni Puspita; Mutiara, Pipyt; Febriyanti, Sapitri
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 8 No. 2 (2024): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v8i2.11363

Abstract

The potential for encountering free radicals poses a significant concern. Ketapang (Terminalia catappa L.) is a plant with antioxidant properties due to secondary metabolites, specifically phenolic compounds. The objective of this study was to determine the total phenolic content and antioxidant activity of ketapang leaves through the utilization of several extraction techniques. The extraction of Ketapang leaves is conducted using various methods, namely maceration, stirring-assisted extraction (SAE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE) with 1:10 solid-solvent ratio. The total phenolic content of the Ketapang leaf extract was determined using the Folin-Ciocalteu technique and quantified using a UV-Visible spectrophotometer set at a wavelength of 782nm. Meanwhile, antioxidant activity measurements were carried out using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and measured at a wavelength of 516nm. The study investigated the total phenolic content and antioxidant activity of Ketapang leaf extract using the maceration method of stirring-assisted extraction (SAE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE), respectively, were 68.495%+2.891, 75.709%+0.106, 84.269%+0.159, and 65.065%+3.965 mgGAE/g and 20.891, 17.569, 15.427, and 21.353 µg/mL. The findings of this study indicate that the ultrasound-assisted extraction technique exhibits the greatest overall phenolic content and antioxidant activity.   Keywords: antioxidant, Terminalia catappa, total phenolic content, ultrasound-assisted extraction
Influence of extraction method on total phenolic content and antioxidant activity of Sappan Wood (Caesalpinia sappan L.) extract Akmal, Tubagus; Tanjung, Yenni Puspita; Julianti, Andi Ika; Lestari, Aulia Gustiani; Aljan, Aljan
Sasambo Journal of Pharmacy Vol. 5 No. 2 (2024): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v5i2.364

Abstract

Sappan wood is a botanical species that contains a high concentration of phenolic compounds, which contribute to several pharmacological properties, including antidiabetic, antibacterial, antioxidant, and wound-healing activities. In order to achieve phenolic compounds of high quality and quantity, it is crucial to select an appropriate extraction procedure. Plant extraction is an important step for chemical isolation, chemical analysis, and evaluating the biological and pharmacological activities of plant compounds. Therefore, determining the most favorable extraction conditions is a critical undertaking in order to maximize both the quantity of active plant compounds and the extraction yield. This research aimed to compare extraction methods based on total phenolic content (TPC) and antioxidant activity (IC50). The extraction techniques employed include maceration, stirring-assisted extraction (SAE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE). The results show TPC values for maceration, SAE, UAE, and MAE, which are 132.85±1.44, 150.99±1.69, 206.70±6.56, and 115.70±1.44 mg GAE/g DE, respectively. The DPPH antioxidant activity (IC50) values are 32.33±2.64, 25.01±0.34, 20.68±0.29, and 29.18±0.70 µg/mL, respectively. The research findings indicate that various extraction procedures can impact the extraction yield, total phenolic content (TPC), and antioxidant activity (IC50) of sappan wood, and UAE is the best extraction method.
Optimization of Phenolic and Flavonoid Extraction in Lavandula Angustifolia using Ultrasonic Assistance Extraction Ananda, Della; Julianti, Andi Ika; Akmal, Tubagus
Reka Buana : Jurnal Ilmiah Teknik Sipil dan Teknik Kimia Vol 10, No 1 (2025): EDISI MARET 2025
Publisher : Universitas Tribhuwana Tunggadewi Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/rekabuana.v10i1.6608

Abstract

Lavender contains active compounds such as flavonoids, tannins, coumarins, phytosterols, and minerals, which possess antioxidant properties and pharmacological potential. This study optimized the extraction process of lavender flowers to maximize bioactive phenolic and flavonoid yields. Ultrasonic-assisted extraction (UAE) was employed, and optimization was conducted using a Box-Behnken design in Design Expert 13.0.5.0 software. The influence of ethanol concentration, liquid-solid ratio (LSR), and extraction time on total phenolic content (TPC) and total flavonoid content (TFC) was evaluated. Results revealed that LSR significantly impacted the responses. Optimal conditions were determined as an LSR of 50 mL/g, extraction time of 26 minutes, and ethanol concentration of 26.12%. Validation under these conditions yielded a TPC of 152.26 mg GAE/g DE and a TFC of 68.59 mg QE/g DE, with percentage errors of −7.7% and 3.5%, respectively, demonstrating excellent agreement with the predicted values.
Co-Authors Akmal, Tubagus Aljan, Aljan Ananda, Della Febriyanti, Sapitri Lestari, Aulia Gustiani Mutiara, Pipyt Tanjung, Yenni Puspita