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All Journal Indonesian Journal of Urology Scientific Journal of Reflection : Economic, Accounting, Management and Business
Nugroho, Achmad
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Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Public Health

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EFFECT OF VITAMIN E (α TOCOPHEROL) ADMINISTRATION ON APOPTOSIS OF GERMINAL CELLS EPITHELIUM TESTIS IN SPRAGUE DAWLEY WHITE STRAIN RATS AFTER EXPOSED BY CISPLATIN Nugroho, Achmad; Djatisoesanto, Wahjoe; Soebadi, Doddy M
Indonesian Journal of Urology Vol 26 No 1 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i1.546

Abstract

Objective: To determine the differences of germinal epithelial testicular cell apoptosis in white Sprague Dawley strain rat that received combination of cisplatin and vitamin E compared to Sprague Dawley strain rat that received cisplatin only. Material & Methods:  Twenty four Sprague Dawley rats were divided into 4 groups randomly. Group 1 Negative Control (NC) was given an injection of 1 cc 0.9% normal saline intraperitoneally as a placebo, group 2 Positive Control (PC) was given 5 mg/kgBW cisplatin intraperitoneally, group 3 (P1) was given cisplatin injection 5 mg/kgBW intraperitoneally + vitamin E (α tocopherol) 50 mg/kgBW by gavage and group 4 (P2) was given cisplatin injection 5 mg/kgBW intraperitoneally + vitamin E (α tocopherol) 200 mg/kgBW by gavage. Vitamin E (α tocopherol) was given 3 weeks before up to 4 weeks after cisplatin injection. Observation of the germinal epithelial cells apoptosis was carried out by calculating germinal epithelial cells apoptosis in the cross-section preparations of the seminiferous tubule which gave a positive reaction to the apoptag staining, using a 400x magnification light microscope. Results: Apoptosis on positive control (PC) group was different significantly compared to the negative control (NC) group (p<0.05). There was a significant difference in the apoptosis of germinal epithelial testicular cells in the cisplatin + vitamin E 50 mg/kgBW compared to the PC group (p<0.05). The cisplatin + vitamin E 200 mg/kgBW group; had a lower number of apoptosis compared to the cisplatin + vitamin E 50 mg/kgBW (p<0.05). Conclusion: Vitamin E provides a protective effect on decreasing the amount of apoptosis due to cisplatin exposure. The protective effect of vitamin E is dose-dependent.
Pengaruh Pelayanan dan Fasilitas Poli Gigi terhadap Kesiapan Tempur Prajurit Pasmar 2 Nugroho, Achmad; Herman, Juli; Ilmi, Muhammad Irfan
SCIENTIFIC JOURNAL OF REFLECTION : Economic, Accounting, Management and Business Vol. 8 No. 2 (2025): SCIENTIFIC JOURNAL OF REFLECTION: Economic, Accounting, Management, & Business
Publisher : Sekolah Menengah Kejuruan (SMK) Pustek

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37481/sjr.v8i2.1087

Abstract

The Marine Corps is tasked with developing the strength and operational readiness of its units and fostering maritime potential into a force for sea defense and security under the Chief of Naval Staff's responsibility. This study aims to analyze the impact of service quality and dental clinic facilities at on the combat readiness of Pasmar 2 personnel. Using a quantitative approach with a descriptive method, the research involved 98 respondents selected from a total population of 7,461 personnel. Data was collected through questionnaires designed to assess respondents' perceptions of the service quality and dental clinic facilities and their impact on combat readiness. The independent variables include service quality and the completeness of dental clinic facilities, while the dependent variable is the combat readiness of personnel. Data analysis was conducted using SPSS version 27, covering validity tests, reliability tests, and regression analysis. The results indicate that both service quality and dental clinic facilities significantly affect personnel's combat readiness, both individually (partial) and collectively (simultaneous). Key influencing factors include the availability of specialist medical staff, adequate medical equipment, and the efficiency of dental health care processes.
Co-Authors Doddy M Soebadi Herman, Juli Ilmi, Muhammad Irfan wahjoe djatisoesanto