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All Journal Media Farmasi Indonesia Indonesian Journal of Jamu
Rahardian, Muhammad Ryan Radix
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Other

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Pemanfaatan Ekstrak Khamir Phaffia rhodozyma Sebagai Sumber Karotenoid Pada Penghambatan Tirosinase Rahardian, Muhammad Ryan Radix; -, Wulandari
Media Farmasi Indonesia Vol. 12 No. 1 (2017): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.262 KB)

Abstract

Abstrak Ekstrak khamir Phaffia rhodozyma mengandung senyawa karotenoid berupa astaxhantin yang memiliki aktivitas sebagai penghambat tirosinase. Senyawa ini dapat menghambat tirosinase dalam mekanisme pembentukan melanin. Ekstrak khamir Phaffia rhodozyma diperoleh dengan cara menyari khamir dengan pelarut aseton dan dikeringkan menggunakan gas N2. Pengukuran aktivitas penghambatan tirosinase dilakukan dengan pengukuran dopakrom menggunakan spektrofotometer UV-Vis pada panjang gelombang 480,5 nm. Hasil penelitian menunjukkan bahwa nilai IC50 hidrokuinon lebih besar dari sampel Ekstrak karotenoid khamir Phaffia rhodozyma, yang mana masing-masing kontrol positif hidrokuinon memiliki nilai IC50 sebasar 90,34 µg/ml dan IC50 Ekstrak karotenoid khamir Phaffia rhodozyma sebasar 113,85 µg/ml.
In Vitro and In Silico Evaluation of Pancreatic Lipase Inhibition by Avicennia marina and Bruguiera gymnorrhiza Fruit Flour Extracts Chairunnisa, Afra; Rahardian, Muhammad Ryan Radix; Pangestuti, Ratih; Franyoto, Yuvianti Dwi; Kusmita, Lia
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia (In Progress)
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.483

Abstract

Indonesia is rich in mangrove species, including Avicennia marina (brayo) and Bruguiera gymnorrhiza (lindur), whose fruits contain bioactive metabolites with potential anti-obesity activity. This study evaluated pancreatic lipase inhibition by brayo and lindur fruit flour extracts (raw and boiled) using in vitro and in silico approaches. Extracts were prepared by remaceration with 70% ethanol. Lipase inhibition was measured using a multimode microplate reader, while metabolites were identified by LC-HRMS and evaluated by molecular docking. Raw brayo showed the highest inhibition (84.29 ± 4.24%), followed by boiled brayo (83.01 ± 4.59%), raw lindur (75.24 ± 3.02%), and boiled lindur (73.88 ± 4.00%). Docking indicated strong binding of luteolin (−8.23 kcal/mol), 9-oxo-10(E),12(E)-octadecadienoic acid (−6.75 kcal/mol), and methyl eleostearate (−6.59 kcal/mol) to pancreatic lipase. These findings support mangrove fruit flour as a natural source of lipase inhibitors for obesity management.
Co-Authors Chairunnisa, Afra Franyoto, Yuvianti Dwi Lia Kusmita Pangestuti, Ratih Wulandari -, Wulandari