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PENGARUH PEMBERIAN AJUVAN ASAM FOLAT TERHADAP FUNGSI PERSONAL DAN SOSIAL PASIEN SKIZOFRENIA KRONIK Suprapti, Rini; Fitrikasari, Alifiati; Pudjo, Rihadini; Asikin, Hang Gunawan; Noerhidajati, Elly
Journal of Nutrition College Vol 10, No 3 (2021): Juli
Publisher : Departemen Ilmu Gizi, Fakultas Kedokteran, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v10i3.30725

Abstract

 Latar Belakang : Hasil pengobatan skizofenia menunjukkan sebanyak 85% mengalami penurunan fungsi. Remisi klinis tidak selalu mengarah pada pemulihan fungsi. Defisiensi folat diidentifikasi sebagai salah satu faktor risiko skizofrenia.Tujuan : Mengetahui manfaat ajuvan asam folat dalam memperbaiki fungsi personal dan sosial pasien skizofrenia kronis.Metode : Penelitian eksperimental dengan desain double blind – randomized controlled trial, pre post test design. Semua subjek yang memenuhi kriteria inklusi diambil menurut waktu (consecutive sampling), kemudian secara blok random dikelompokkan dalam kelompok perlakuan dan kelompok kontrol. Perlakuan dengan ajuvan asam folat 2 mg / hari selama 4 minggu. Kelompok kontrol mendapatkan anti psikotik dengan plasebo. Anti psikotik yang digunakan tidak sama. PSP diukur sebelum dan sesudah perlakuan. Instrumen penelitian menggunakan kuesioner sosiodemografi dan kuesioner wawancara terstruktur Personal and Social Performance Scale versi Indonesia.Hasil :  Terdapat 66 subjek yang memenuhi kriteria inklusi, 2 diantaranya Drop Out karena kejang dan SNM. Uji komparatif karakteristik demografik kelompok perlakuan dan kelompok kontrol tidak ada perbedaan bermakna. Terdapat peningkatan skor PSP yang bermakna secara statistik p <0,01 di kedua kelompok dengan peningkatan skor PSP kelompok perlakuan lebih tinggi (p = 0,029).Simpulan : Ajuvan asam folat memperbaiki fungsi sosial dan personal pasien skizofrenia kronis.
Disorders of Sex Development: A Review of Medical and Psychosocial Aspects Saktini, Fanti; Asikin, Hang Gunawan; Sarjana A.S, Widodo; Utari, Agustini
Diponegoro International Medical Journal Vol 5, No 2 (2024): December 2024
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v5i2.25084

Abstract

Background: Disorders of Sex Development (DSD) refer to a spectrum of congenital conditions involving atypical chromosomal, gonadal, or phenotypic development. Although recent studies have improved our understanding of the medical management of DSD, the psychosocial impact and the role of multidisciplinary care in addressing these challenges remain less well known.Objective: This review aims to examine the classification, diagnostic approaches, and medical and psychosocial challenges associated with DSD, while also highlighting the importance of multidisciplinary support.Methods: A narrative review was conducted to explore the current research and clinical guidelines on DSD, including studies on medical management and psychosocial interventions.Results: The review found that early diagnosis and management are essential to reducing life-threatening risks and psychosocial distress in individuals with DSD. The impact of societal stigma, gender identity complexities, and increased rates of anxiety and depression were observed to contribute to body image concerns. A multidisciplinary care team, involving psychiatrists, endocrinologists, and other specialists, was highlighted as critical for holistic patient care.Conclusion: The findings underscore the importance of a multidisciplinary approach in addressing both the medical and psychosocial aspects of DSD. While collaborative decision-making and individualized care strategies showed positive outcomes, further research is needed to optimize long-term health and quality of life for individuals with DSD.