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Intraoperative Pancreatic Assessment in Pancreaticoduodenectomy The Correlation with Pancreatic Fistula Formation Mazni, Yarman; Syafiuddin, Ardani F; Putranto, Agi S
The New Ropanasuri Journal of Surgery Vol. 5, No. 1
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Background Pancreatic cancer affects 25,000 to 30,000 people in the United States each year and is the fourth or fifth leading cause of cancer-related death in this country. It is generally resected by pancreaticoduodenectomy, with or without preservation of the pylorus and proximal duodenum. Anastomotic leaks, intra-abdominal abscesses, and delayed gastric emptying account for most of the perioperative complications after pancreaticoduodenectomy. Anastomotic leaks of pancreas are resulted pancreatic fistula about 45%. A lot of study that have been done to find risk factors of postoperative pancreatic fistula (POPF) with contradictive results. Method This study was done for 70 patients of pancreaticoduodenectomy procedure. Data was collected from medical record in 2016-2019. The data are pancreatic texture, pancreatic duct diameter, pancreaticojejunal anastomotic technique, use of stent in pancreaticojejunal, and POPF. We analyzed the data bivariat with Spearman. Results There are 41,4% male and 58,6% female, Patient with underweight about 21,4%, normoweight 57,1%, overweight 15,7%, dan obese 5,7%. Patient with Diabetes Melitus (DM) about 11,4% and no DM 88,6%. The mean of blood glucose is 136,03 mg/dl. Patient with no POPF about 21,4% and with POPF 78,6%. The A type POPF about 69,1%, B type 14,5%, and C type 16,4%. Pancreatic duct diameter 78,6% and >3 mm about 21,4%. Soft texture pancreas about 22,9% and hard 77,1%. Use of stent about 21,4% and no stent 78,6%. Pancreaticojejunal anastomotic type of dunking or invaginating about 82,9% and duck to mucosa sebanyak 17,1%. The significant risk factor in univariate analysis is diameter of the pancreatic duct (p=0,007). Conclusion Diameter of the pancreatic duct can be used as a risk factor to predict POPF in pancreaticoduodenectomy procedure.
The use of Laparoscopy In Treatment of Perforated Peptic Ulcer: A Literature Review Soeratman, Alif R; Putranto, Agi S
The New Ropanasuri Journal of Surgery Vol. 5, No. 2
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Quality of Life of Post-Gastrectomy Patients: A Study in Indonesia's National Central Hospital Napitupulu, Herlan; Putranto, Agi S
The New Ropanasuri Journal of Surgery Vol. 6, No. 1
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Introduction. Several studies suggest gastrectomy is associated with deterioration in a patient's quality of life (QOL). This study is conducted to assess the impact of distal (DG), proximal (PG), or total (TG) gastrectomy and the cause of disease on a patient's QOL. Method. This retrospective study was conducted in dr. Cipto Mangunkusumo Hospital with collected data from the medical records throughout July-September 2020. Inclusion criteria were patients after proximal, distal, or total gastrectomy for a tumor or any non-tumor indications. They were assessed using the World Health Organization Quality of Life Questionnaire Abbreviated Version (WHOQOL-BREF). Collected data were further analyzed using statistical univariate and bivariate analysis. Results. Sixty-six patients with a mean age of 47.12 ± 14.5 years were enrolled in the study. We found significant differences between the proximal, distal, and whole groups with the environmental domain and the total WHOQOL-BREF values. The median scores for the environmental domain were 63 (50–88), 69 (50–88), 56 (50–75), and the mean WHOQOL-BREF total scores for proximal, distal, and total gastrectomy patients were 64.42 ± 9.34, 67.19 ± 9.44, 59.12 ± 8.04 for the proximal, distal, and total groups, respectively. Subjects with an etiology of malignancy had a lower median WHOQOL-BREF score in most domains. However, there was no significant difference in WHOQOL-BREF scores between non-tumor and tumor subjects. Conclusion. This study found decreasing patients' QOL after total gastrectomy compared with distal and proximal in the environmental domain and the total WHOQOL-BREF value. There was no difference in post-gastrectomy patients' QOL between tumor and non-tumor etiology in all WHOQOL-BREF domains.
Prediction of Liver Volume from Liver Transplant Donor using Biometric Formula compared with Computed Topography Volumetry Putranto, Agi S; Syafina, Adinda B; Sekarsari, Damayanti; Mazni, Yarman; Moenadjat, Yefta
The New Ropanasuri Journal of Surgery Vol. 6, No. 1
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Introduction. Liver volume calculation is critical in assessing the compatibility and resectability of the graft in living donor liver transplants (LDLT). An accurate estimation of liver volume is a predictor for successful LDLT. The gold standard of liver volume estimation is CT Volumetry. Despite several limitations in the availability of software, facility, and time consumed, there is still disagreement of biometric formula to predict liver volume in Indonesia. Methods: A cross-sectional design study was carried out in Dr. Cipto Mangunkusumo General Hospital, enrolling those who underwent liver transplantation from 1st January 2010 – 3rd October 2019. Bodyweight, body height, body mass index, body surface area, and CT volumetry were the variables of interest in the study and were subjected to analysis. Result. Body weight, body height, and body surface area are found from multivariate analysis in this research. Multivariate logistic regression of body weight with caudal liver volume giving out liver volume estimated equation of estimate liver volume of 479.23 + 13.95 (bodyweight). The equation in this study proposes a biometric formula to estimate liver volume using bodyweight based on Indonesian anthropometry. Conclusion: Bodyweight is proposed for equation formation based on a characteristic patient feature in Indonesia. Accuracy testing of the liver estimation equation discovered in this study proposed an entirely satisfactory result in the Indonesian population
Factors Affecting Renal Function on Ileostomy in Dr. Cipto Mangunkusumo General Hospital: a Cross-sectional study Sihardo, Lam; Putranto, Agi S
The New Ropanasuri Journal of Surgery Vol. 6, No. 2
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Introduction. Every year, about 30—60 ileostomy with various underlying diseases and indications were created in Dr. Cipto Mangunkusumo General Hospital (CMGH). There were a lot of complications attributable to these creations; one is the decline of renal function. The study goal was to find out factors influencing the renal function of ileostomy in CMGH. Method. A cross-sectional study was conducted using medical records in April – May 2021. Samples were taken using the purposive sampling method. Inclusion criteria include male or female patients who underwent ileostomy closure in CMGH in the last four years with complete BMI, ileostomy creation and closure, serum creatinine, and estimated glomerular filtration rate (eGFR). Patients with underlying renal dysfunctions were excluded. The data were analyzed using univariate and bivariate analysis. Spearman’s test was used to analyze the correlation. Results. There were 55 subjects enrolled in the study. BMI (peGFR = 0.044; pcreatinine = 0.015), time of ileostomy closure (peGFR = 0.014; pcreatinine = 0.012), and high output ileostomy (peGFR = 0.032; pcreatinine = 0.018) were statistically significant as risk factor diminishing the renal function. The correlation analysis showed that time of ileostomy closure was significantly different for eGFR and serum creatinine values with p = 0.039 (r = -0.279) and p = 0.021(r = 0.310), respectively. Conclusion. In the study, factors that affect critical renal function in ileostomy were high output ileostomy, time of ileostomy closure, and body mass index. Hydration status, underlying disease, and age did not affect the diminished renal function.
Serum CEA Level in Predicting Liver Metastases of Colorectal Cancer Among Young Adult Patients Sihotang, Ely S.P; Putranto, Agi S
The New Ropanasuri Journal of Surgery Vol. 7, No. 1
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Introduction: Incidence and mortality of CRC are currently increasing in those under 50 years. The study aims to determine the predictive value of serum CEA levels as the liver metastases predictor of colorectal cancer (CRC) in young adults. Methods: A cross-sectional study was conducted using secondary data (patient medical records) from 2015–to 2021. Patients aged <50 years who were diagnosed histopathologically with primary colorectal cancer at dr. Cipto Mangunkusumo General Hospital (CMGH) were recruited. We excluded patients with a history of other malignancies, who had undergone operative management for colorectal cancer, and preexisting liver disease. The outcome of this study is the cut-off of the CEA value obtained by the ROC curve and the sensitivity and specificity of the CEA value in predicting CR liver metastases. Results: Out of 181 subjects enrolled, a total of 43.6% were female. Fifty-nine subjects (32.6%) had liver metastases. The CEA level of the metastases group was 208.1 (2.1–12503.2) ng/mL; this was much higher than the non-metastases group, which was 6.27 (0.8– 1099.4) ng/mL (p <0.001). The AUC value was at 0.904, and the CEA level cut-off was 38.765 ng/mL (Youden's Index = 1.718). The sensitivity and specificity were 91.53% (91.5 CI, 81.32%– 97.19%) and 80.3% (72.16%– 86.97%), respectively. The odds ratio of young colorectal cancer patients having liver metastases was 44.10 (95% CI, 15.92–122.20). Conclusion: CEA level ≥38.765 ng/mL has good sensitivity and specificity in predicting liver metastases among young adults with CRC.
Review: Management of Complex Anal Fistula Putranto, Agi S; Layardi, Winda J
The New Ropanasuri Journal of Surgery Vol. 7, No. 1
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Introduction. Complex anal fistula has a high postoperative recurrence rate and incontinence as well. There have been many emerging surgical techniques, but there are no new recommendations for managing complex anal fistula. One of the critical parameters in evaluating surgical technique outcomes is the recurrence rate and incontinence. This study describes postoperative results in recurrence rates and incontinence in various surgical techniques in managing complex anal fistula. Method. This review commenced with literature searches on online databases, including Cochrane Library, MEDLINE (PubMed), ScienceDirect, and CINAHL (EBSCOhost). Results. The study enrolled two RCTs, four systematic reviews, 14 retrospective and prospective studies, and a case series. The recurrence rate and incontinence of fistulotomy, seton drainage, advancement flap, were 4-19% and 0-4%, 3-47% and 0-7%, 20-27%, and 0-38%, respectively. The recurrence rate of LIFT, VAAFT, PERFACT, and TROPIS were 7-16.1%, 7.5-33%, 20-26.7%, and 14%, respectively; no change in pre– and postoperative continence scores. Conclusions. According to this study, the lowest recurrence rate was in the TROPIS procedure and the highest in fistulotomy. Meanwhile, the lowest incidence of incontinence was in LIFT, VAAFT, PERFACT, and TROPIS, and the highest was in the advancement flap procedure.
Transplantation in Pediatrics Liver Failure Associated with Acute Hepatitis of Unknown Etiology Putra, Afid B; Putranto, Agi S; Risyaldi, Muftah; Nurachman, Luthfian A
The New Ropanasuri Journal of Surgery Vol. 7, No. 2
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Introduction. On 5th April 2022, some cases of severe acute hepatitis of unknown etiology in children were reported in the United Kingdom. Since then, the number has increased rapidly, with 650 probable cases identified worldwide. This review focuses on available information about managing acute liver failure (ALF) in pediatrics with acute hepatitis of unknown etiology through the perspective of hepatobiliary surgery. Method. A literature review proceeded on some databases, namely PubMed and Google Scholar. Epidemiological data and technical policy were obtained from World Health Organization and some government institutions. Results. Severe acute hepatitis can progressively develop into acute liver failure, thus requiring a liver transplantation procedure immediately. There are about 30 patients have received a liver transplant. Fourteen patients reported had died. Liver transplantation is necessary to treat acute liver failure in children with acute hepatitis of unknown etiology. The need for a liver transplant can be avoided if ALF is prevented. Conclusion. The decision to perform or not to perform a liver transplant procedure may consider indications, contraindications, possible outcomes, patient status, availability of donors, and access to transplant centers' facilities and resources.
Quality of Life and Its Associated Factors in Patients After Esophagectomy at a Single National Referral Center Sirirui, Dogma H.; Putranto, Agi S
The New Ropanasuri Journal of Surgery Vol. 7, No. 2
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Introduction. Esophagectomy is the standard surgical treatment for resectable esophageal cancer patients. However, the success rate for this procedure was about 25–35% and was associated with a severe risk of postoperative complications. In addition, patients after esophagectomy have decreased their quality of life (QOL), but no research has been done in Indonesia. Therefore, this study was conducted to determine the quality of life after esophagectomy in Indonesia based on the patient population at Dr. Cipto Mangunkusumo General Hospital (CMGH). Method. A retrospective study was conducted using quality–of–life instruments issued by the European Organization for Research and Treatment of Cancer (EORTC). It consists of the module for esophageal cancer EORTC–QLQ–OES18 and the core questionnaire C30. Subjects were patients after esophagectomy in 2015–2021 at CMGH. Results. About 35 subjects underwent esophagectomy and followed by reconstruction, which comprised 62.9% males and 37.1% females. The mean age was 43.8 + 13.1 years. All subjects' median global health was 83.3 (IQR: 25.0). The overall functional scale question item with the lowest score was cognitive functioning (CF) 66.7 (IQR: 50.0). Meanwhile, based on the question items on the overall symptom scale, the worst scores were nausea and vomiting (NV) 16.7 (IQR: 50.0), pain (PA) 16.7 (IQR: 33.3), dysphagia (OESDYS) 33.3 (IQR: 33.3), eating (OESEAT) 34.5 (IQR: 23.9), choking (OESCH) 33.3 (IQR: 33.3), and coughing (OESCO) 33.3 (IQR: 33.3). Conclusion. The overall QOL after esophagectomy at CMGH based on the EORTC–QLQ–C30 and OES18 questionnaires was good. However, prognostic factors associated with decreased quality of life should be better educated to patients and prepared well before the esophagectomy procedure, thus maximizing quality of life after esophagectomy.
A Glimpse of Liver Resection Profile in An Indonesian Tertiary Hospital: A Retrospective Descriptive Study Vaniara, Florencia V; Lalisang, Arnetta NL; Lalisang, Toar JM; Mazni, Yarman; Putranto, Agi S; Jeo, Wifanto S; Ibrahim, Febiansyah; Syaiful, Ridho A; Sihardo, Lam; Marbun, Vania MG
The New Ropanasuri Journal of Surgery Vol. 10, No. 1
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Introduction. In-depth liver resection profile is needed for evaluation to improve the procedure’s outcome. This study aims to describe the clinical characteristics and outcomes of liver resection in HCC patients in Cipto Mangunkusumo Tertiary Hospital. Methods. This study retrospectively analyzed the clinical data of 19 HCC patients who underwent liver resection in Cipto Mangunkusumo Tertiary Hospital from 2021 to 2024. Demographic, clinical, laboratory, operative, and pathological data were collected. Postoperative complications were assessed using the Clavien-Dindo classification system within 30- and 90-day postoperative periods. Result. Nineteen patients were included, comprising 12 (63.2%) males and 7 (36.8%) females. Sixteen patients (84.2%) had Child-Pugh (CP) class A liver function with 10 (62.5%) CP A(5) patients and 6 (37.5%) CP A(6) patients; 3 (15.8%) patients had CP class B(7). There were 6 (31.6%) patients with thrombocytopenia and 4 (21.1%) patients with portal hypertension. Liver resection was done laparoscopically in 4 (21.1%) patients and with an open approach in 15 (78.9%) patients. Left hepatectomy was done in 3 patients (15.78%), right hepatectomy in 2 (10.5%), right anterior sectionectomy in 4 (21%), left lateral sectionectomy in 1 (5.26%), bisegmentectomy in 1 (5.26%), segmentectomy in 6 (31.58%), and non-anatomical resection in 2 (10.52%). Based on histopathologic examination, HCC was found in 13 (68.41%) patients. Among 19 patients, 12 (63.2%), 5 (26.3%), and 2 (10.5%) patients had 1 tumor, 2 tumors, and 3 tumors respectively (total tumors resected: n=28). About 16 (84.21%) patients had elevated alpha fetoprotein (AFP) (> 10 ng/mL). The mean intraoperative blood loss was 884 mL. No postoperative complications classified as Clavien-Dindo grade I-IV were observed. Two patients (10.5%) experienced postoperative mortality within 90 days (Clavien-Dindo grade V), both due to circulatory failure. Conclusion. This study presents a descriptive overview of liver resection in an Indonesian tertiary hospital. Comparative conclusions should be interpreted with caution due to the limited sample size.