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All Journal International Journal of Public Health Science (IJPHS) The New Ropanasuri Journal of Surgery The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Ibrahim, Febiansyah
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Global Leadership Initiative on Malnutrition criteria for predicting surgical site infection in elective laparotomy patients Octaviani, Pauline; Wulandari, Yohannessa; Ibrahim, Febiansyah; Andayani, Diyah Eka
International Journal of Public Health Science (IJPHS) Vol 13, No 4: December 2024
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v13i4.24175

Abstract

Laparotomy surgery patients are at risk for complication including surgical site infections (SSI) which are associated with high morbidity and mortality. Malnutrition has been identified as a risk factor for the occurrence of SSI but preoperative malnutrition identification remains low. The Global Leadership Initiative on Malnutrition (GLIM) has published a new, practical, and easily applicable definition of malnutrition. This study aims to evaluate whether malnutrition according to GLIM criteria is a predictor of SSI in elective laparotomy patients. This prospective cohort study involved 123 subjects aged 18-65 years undergoing elective laparotomy, without diabetes history. Their malnutrition status was assessed using GLIM criteria with bioelectrical impedance analysis (BIA) to evaluate muscle mass. A total 62 subjects were categorized into the malnutrition group and the remaining into nonmalnutrition group and then monitored for the presence of SSI up to 10 days postoperatively. SSI occurred in 13.8% of the subjects. The analysis showed a strong association between malnutrition and SSI in elective post laparotomy (RR 4.6; 95%CI 1.4-15.1; p=0.005). Malnutrition according to GLIM criteria is a significant predictor of SSI in elective post laparotomy patients.
The Role of Circulating Tumour Cells and Carcinoembryonic Antigen as Diagnostic Tool for Metastatic Colorectal Cancer in Indonesia Angraeni, Sri; Abdullah, Murdani; Hasan, Irsan; Rinaldi, Ikhwan; Fauzi, Achmad; Martin, Cleopas; Shatri, Hamzah; Irawan, Cosphiadi; Nursyirwan, Saskia Aziza; Ibrahim, Febiansyah; Siregar, Lianda; Loho, Imelda Maria; Waspodo, Agus Sudiro; Margaluta, Ariansah; Firsyada, Fajar; Darnindro, Nikko; Lutfiah, Evah; Tanadi, Caroline; Ilyas, Mohammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 3 (2025): VOLUME 26, NUMBER 3, December, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2632025245-254

Abstract

Background: Patients with metastatic colorectal cancer (CRC) have a poor prognosis, with a 5-year survival rate of only 14%. Early detection and early intervention may improve outcome. Both circulating tumour cells (CTC) and serum carcinoembryonic antigen (CEA) have been suggested as diagnostic biomarkers for metastatic CRC. This study explored the performance of CTC and CEA as a tools for the detection of metastatic colorectal cancer in Indonesia.Methods: This study was conducted from December 2024 to April 2025 on metastatic colorectal cancer patients from three hospitals in Jakarta. CTC was analysed using the gradient density method and flow cytometry. CEA was analysed using chemiluminescent microparticle immunoassay.Results: This study recruited 160 patients with colorectal cancer patients of whom, 45% were known to have metastatic colorectal cancer. The median age was 57 (47—66) years and analysis was done at one time point only. The area under the curve (AUC) for CTC, CEA, and the combination of both CTC and CEA in diagnosing metastatic colorectal cancer was 0.579, 0.811, and 0.703, respectively. CTC showed 56.94% sensitivity and 50.00% specificity in detecting metastatic colorectal cancer. Meanwhile, CEA showed higher sensitivity (72.22%) and specificity (72.72%). Combination of both CTC and CEA increased sensitivity to 91.67%, but with a lower specificity of 37.50%. The optimal cut-off for CTC and CEA were 34.5 cells/3 ml and 18.31 ng/ml, respectively.Conclusion: CEA showed a better performance than CTC in diagnosing metastatic colorectal cancer. Combination of CTC and CEA showed promising potential as a valuable surveillance tool for detecting metastasis in colorectal cancers, but not as a primary diagnostic tool. 
A Glimpse of Liver Resection Profile in An Indonesian Tertiary Hospital: A Retrospective Descriptive Study Vaniara, Florencia V; Lalisang, Arnetta NL; Lalisang, Toar JM; Mazni, Yarman; Putranto, Agi S; Jeo, Wifanto S; Ibrahim, Febiansyah; Syaiful, Ridho A; Sihardo, Lam; Marbun, Vania MG
The New Ropanasuri Journal of Surgery Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. In-depth liver resection profile is needed for evaluation to improve the procedure’s outcome. This study aims to describe the clinical characteristics and outcomes of liver resection in HCC patients in Cipto Mangunkusumo Tertiary Hospital. Methods. This study retrospectively analyzed the clinical data of 19 HCC patients who underwent liver resection in Cipto Mangunkusumo Tertiary Hospital from 2021 to 2024. Demographic, clinical, laboratory, operative, and pathological data were collected. Postoperative complications were assessed using the Clavien-Dindo classification system within 30- and 90-day postoperative periods. Result. Nineteen patients were included, comprising 12 (63.2%) males and 7 (36.8%) females. Sixteen patients (84.2%) had Child-Pugh (CP) class A liver function with 10 (62.5%) CP A(5) patients and 6 (37.5%) CP A(6) patients; 3 (15.8%) patients had CP class B(7). There were 6 (31.6%) patients with thrombocytopenia and 4 (21.1%) patients with portal hypertension. Liver resection was done laparoscopically in 4 (21.1%) patients and with an open approach in 15 (78.9%) patients. Left hepatectomy was done in 3 patients (15.78%), right hepatectomy in 2 (10.5%), right anterior sectionectomy in 4 (21%), left lateral sectionectomy in 1 (5.26%), bisegmentectomy in 1 (5.26%), segmentectomy in 6 (31.58%), and non-anatomical resection in 2 (10.52%). Based on histopathologic examination, HCC was found in 13 (68.41%) patients. Among 19 patients, 12 (63.2%), 5 (26.3%), and 2 (10.5%) patients had 1 tumor, 2 tumors, and 3 tumors respectively (total tumors resected: n=28). About 16 (84.21%) patients had elevated alpha fetoprotein (AFP) (> 10 ng/mL). The mean intraoperative blood loss was 884 mL. No postoperative complications classified as Clavien-Dindo grade I-IV were observed. Two patients (10.5%) experienced postoperative mortality within 90 days (Clavien-Dindo grade V), both due to circulatory failure. Conclusion. This study presents a descriptive overview of liver resection in an Indonesian tertiary hospital. Comparative conclusions should be interpreted with caution due to the limited sample size.
Management of Gastrointestinal Tract Arteriovenous Malformations in Adults: A Literature Review Ibrahim, Febiansyah; Beatrice, Angie
The New Ropanasuri Journal of Surgery Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Arteriovenous malformations (AVMs) of the gastrointestinal (GI) tract are rare vascular lesions that can cause significant GI bleeding, posing a diagnostic challenge in clinical practice. This literature review examines the management strategies for AVMs in adults, focusing on identifying optimal treatment approaches and minimizing recurrence, particularly in Indonesia where no standardized treatment guidelines are available. Method. A literature search was conducted from August 24, 2022, to September 11, 2023, using PUBMED®, Cochrane®, Proquest®, and Scopus® databases. The inclusion criteria were studies published in English or Indonesian within the last 25 years, including case series, cohort studies, or systematic reviews involving patients with GI AVMs. The Joanna Briggs Institute Critical Appraisal Checklist was used for evaluating study quality. After screening for relevance and duplicates, 5 studies met the inclusion criteria. Result. Database search using specific keywords obtained in total of 1012 titles. Screening of titles and abstracts then 5 studies met the criteria. AVMs were reported in various anatomical locations of gastrointestinal tract. Including ileum, colon, and duodenum. Treatment strategis tailored into three major approaches: operative, non-operative (minimally invasive including interventional radiology), and medical. Transarterial embolization (TAE) which emerged as the most frequent employed and effective modality in both emergent and elective settings. Recurrence rates following TAE varied but were generally lower than those observed with conservative or incomplete interventions. Endovascular embolization also served as a valuable alternative in patients who declined surgical intervention or when lesions were inaccessible surgically. Conclusion. Advancement in endovascular interventional radiology and super-selective embolization have led to effective management of non-variceal gastrointestinal bleeding, including AVMs with minimal recurrence, though organ ischemia remains a risk. Surgical intervention is crucial when embolization fails or complications arise. Innovations in intraoperative AVM localization have improved surgical accuracy and reduced recurrrence.
Co-Authors Achmad Fauzi Agus Sudiro Waspodo Andayani, Diyah Eka Angraeni, Sri Beatrice, Angie Cosphiadi Irawan E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Firsyada, Fajar Ikhwan Rinaldi Ilyas, Mohammad Imelda Maria Loho, Imelda Maria Irsan Hasan Jeo, Wifanto S Lalisang, Arnetta NL Lianda Siregar Lutfiah, Evah Marbun, Vania MG Margaluta, Ariansah Martin, Cleopas Mazni, Yarman Murdani Abdullah Nikko Darnindro Octaviani, Pauline Putranto, Agi S Saskia Aziza Nursyirwan, Saskia Aziza Sihardo, Lam Syaiful, Ridho A Tanadi, Caroline Toar J.M. Lalisang Vaniara, Florencia V Wulandari, Yohannessa