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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan
Agus Aulung
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Health Professions Medicine & Pharmacology

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DAYA HAMBAT EKSTRAK BIJI JINTAN HITAM (Nigella sativa Linn.) TERHADAP PERTUMBUHAN Candida albicans Siti Maryam Istiqomah; Agus Aulung; Luh Eka Purwani
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (2015): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3035.198 KB) | DOI: 10.33533/jpm.v9i1.822

Abstract

Infectious disease caused by candida is called Candidiasis and the species that mostly causes candidiasis is Candida albicans. Some fungal drugs have side effects that evoke discomfort, such as gastrointestinal disorde. Black cumin seed is traditional medicine that contains thymoquinoneas tha main indigredient that acts as an antifungal. This study was designed to study the antifungal inhibition activity of black cumin seed (N. sativa Linn) extract againts Candida albicans growth. This study used an experimental laboratory with the in vitro diffusion method in Sabouraund dextrose agar in order to observe and measure growth inhibition. Black cumin seed extract was obtained from Research Institute for Medicinal an Aromatic Plants (BALITRO) Bogor. The study showed that growth inhibition by the following concentration 100, 80, 60, 40, 20 and 10% with the mean of inhibition activity were 9.00; 4.83; 2.87; 2.49 and 0.19 mm. the data were analyzed by using alternative test and showed the probability score value of p < 0.05. It was concluded that black cumin seed extract had inhibition activity againts Candida albicans growth in vitro.
Larvicidal Activity and Histopathological Midgut Alteration of Aedes Aegypti Larvae Induced by Methanol Extract Mahkota Dewa fruit (Phaleria Macrocarpa (Scheff). Boerl) Nurul Eliza; Rizal Subahar; Agus Aulung
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i2.2983

Abstract

Aedes aegypti is the main vector of DHF in Indonesia. The use of synthetic insecticide results in vector resistance. Mahkota Dewa fruits (Phaleria macrocarpa (Scheff) Boerl) contain flavonoids, saponins, and tannins. Thus, it has the potential as a natural larvicide against Ae. aegypti larvae. The objective of the study was to determine the effectiveness of methanol extract Mahkota Dewa fruit. This research was experimental, used methanol extract Mahkota Dewa fruit at concentration 0.1%, 0.15%, 0.20%, 0.25% and 0.30%, then added 25 larvae each concentration and repeated 3 times. After 24 and 48 hours of exposure, the mortality of larva was counted and then calculated LC50 and anterior midgut histopathology. LC50 values 0,554% (0,391-11,397) and anterior midgut histopathology shows epithelial damage. Mahkota Dewa fruits with methanol extract have activity as larvicide larvae instar III-IV Ae. aegypti.
Co-Authors Luh Eka Purwani Nurul Eliza Rizal Subahar Siti Maryam Istiqomah