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All Journal Medical Journal of Indonesia E-Journal Widya Kesehatan dan Lingkungan Jurnal Ilmiah Widya Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Anakes: Jurnal Ilmiah Analis Kesehatan Indonesian Journal of Medical Chemistry and Bioinformatics
Rizal Subahar
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Multiple cysticercus nodules in skin and brain in a Balinese woman: A case report Margono, Sri S.; Himawan, Sutisna; Purnama, Teddy A.; Subahar, Rizal; Hamid, Abdulbar; Ito, Akira
Medical Journal of Indonesia Vol 11, No 3 (2002): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.905 KB) | DOI: 10.13181/mji.v11i3.65

Abstract

A case of multiple subcutaneous and cerebral cysticercosis in a 33-year-old Balinese female, is reported. The patient suffered from seizures since adolescence, which was not treated. Since three years before admission she started developing multiple nodules in the skin, starting from her forehead and since a year ago also in other parts of the head and body such as shoulders, chest and back. Serum sample tested against cysticercus antigen by immunoblot assay against antigen of Taenia solium was positive. The copro-antigen test was also positive, indicating the presence of the adult worm in the intestines. The patient was treated with praziquantel for the adult T. solium infection and thereafter with albendazole for the larval stages, which resulted in obvious reduction of the cerebral cysts and most of the subcutaneous nodules disappeared. However the adult worm was not recovered in the 24 hours stool specimen and after one year the immunoblot test was still positive. (Med J Indones 2002; 11: 169-73) Keywords: cysticercosis, Taenia solium, praziquantel, albendazole
PENGARUH SUHU DAN KELEMBABAN UDARA TERHADAP KEBERADAAN TUNGAU DEBU RUMAH DI PAMULANG DAN JAKARTA Subahar, Rizal; Aulung, Agus; Firmansyah, Nurhadi Eko; Lubis, Nadar Sukri; Wibowo, Heri
E-Journal Widya Kesehatan dan Lingkungan Vol. 1 No. 2 (2018)
Publisher : E-Journal Widya Kesehatan dan Lingkungan

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Abstract

Tungau debu rumah (TDR) dapat ditemukan di rumah penduduk perkotaan dan keberadaan TDR dipengaruhi oleh suhu dan kelembaban relatif. Penelitian ini bertujuan untuk mengevaluasi suhu dan kelembaban relatif udara mempengaruhi keberadaan TDR di rumah penduduk di wilayah perkotaan Pamulang dan Jakarta. Sebanyak 52 debu rumah penduduk di Pamulang dan 44 di Jakarta diperiksa dengan metode langsung menggunakan mikroskop untuk mendeteksi TDR di dalam sampel debu. Suhu dan kelembaban udara di dalam rumah penduduk diukur dengan alat termohigrometer. Pengambilan debu rumah dilakukan 3 kali dengan selang waktu 2 minggu sekali. Spesies TDR yang ditemukan, yaitu Dermatophagoides pteronyssinus, D.farinae dan Glyciphagus destructor. Secara staitistik, selama 3 kali pengambilan sampel debu, keberadaan TDR pada suhu 30-35oC dan <30oC tidak berbeda bermakna di Pamulang dan Jakarta (p<0,05). Keberadaan TDR pada kelmbaban udara 60-70% berbeda bermakna dengan kelembaban udara <60% pada pengambilan sampel ketiga di Pamulang dan Jakarta (p<0,05). Dapat disimpulkan bahwa keberadaan TDR dipengaruhi oleh kelembaban, tetapi suhu tidak di daerah perkotaan.
KONTAMINASI PARASIT USUS PADA ASINAN SAYURAN MENTAH YANG DIJUAL OLEH PEDAGANG KELILING DI DAERAH TANGERANG SELATAN, BANTEN Manan, Widiastuti S; Susanto, Lisawati; Aulung, Agus; Subahar, Rizal; Maemunah, Ade Siti; Suriptiastuti, Suriptiastuti
Jurnal Ilmiah Widya Vol 4 No 3 (2018)
Publisher : Lembaga Layanan Pendidikan Tinggi Wilayah III Jakarta

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Abstract

ABSTRAK: Konsumsi sayuran mentah memainkan peranan epidemilogi yang penting dalam penularan penyakit parasit yang berasal dari makanan. Tujuan penelitian ini untuk mengetahui penyebaran  parasit usus manusia di dalam air asinan sayuran mentah  yang dijual oleh pedagang, di Tangerang Selatan, Banten. Rancangan penelitian ini , yaitu lintang sewaktu dilaksanakan pada bulan Maret-Mei 2014. Sampel adalah kuah (air) asinan dari asinan sayuran yang  mengaandung asam asetat (CH3COOH) dan dikumpulkan secara acak dari pedagang asinan di 5 wilayah Tangeang  Selatan, yaitu  Ciputat, Pamulang, Pondok Aren, Pondok Benda, dan Serpong. Air asinan disaring dan disentrifus 2500 rpm selama 5 menit untuk mendapatkan sedimen  stadium parasit usus tersebut. Sedimen tersebut diperiksa langsung di bawah mikroskop dengan pewarnaan lugol. Asinan  sayuran terebut terdiri dari kol,  tauge dan wortel. Dari 30 sampel air asinan, semua sampel positif parasit usus (30/30, 100%).  Angka prevalensi parasit usus yaitu 26,7% di Pondok Aren, 26,1%  Pondok Benda, 16,8% Ciputat, 15,7% Serpong, and 14,8% Pamulang. Selain itu, telur Ascaris lumbricoides sebesar 78,1%,  telur Trichuris trichiura 20,1%, telur cacing tambang 1,8%, kista Entamoeba histolytica 62,8%, kista E. coli 9,1%, dan kista Giardia lamblia 28,1%. Penelitian ini menyimpulkan bahwa  parasit usus pada manusia tersebut tersebar luas di wilayah Tangerang Selatan, Banten.Kata kunci: asinan sayur mentah, parasit usus manusia, Tangerang Selatan ABSTRACT: Consumption of raw vegetables plays a major epidemiological role in the transmission of parasitic food-borne diseases. The aim of this study was to know the distribution of the human  intestinal parasites in  water of pickled raw vegetables which were sold by vendors,  in  Southern Tangerang, Banten. A study, cross-sectional design, was undertaken in March to May 2014. The samples were water  of pickled raw vegetables, contained vinegar solution (Acetic acid, CH3COOH), and were randomly collected from vendors in 5 areas in Southern Tangerang, namely Ciputat, Pamulang, Pondok Aren, Pondok Benda, and Serpong. The pickling water was filtered and centrifuged, 2500 rpm for 5 minutes, to obtain sediments of the intestinal parasitic stages. The sediments were direct examined by lugol’s stain..The raw vegetable pickles consisted of cabbage, bean sprouts, and carrot. Of 30 samples, all samples were positive intestinal parasites (30/30, 100%). The prevalence rates of the  intestinal parasites were 26.7% in Pondok Aren, 26.1%  Pondok Benda, 16.8% Ciputat, 15.7% Serpong,, and 14.8% Pamulang. In addition,  Ascaris lumbricoides eggs were 78.1%, Trichuris trichiura eggs 20.1%, hookworm eggs 1.8%, Entamoeba histolytica cysts 62.8%, E. coli cysts 9.1%, and Giardia lamblia cysts 28.1%.This study concluded that the human intestinal parasites were widely distributed in  Southern Tangerang, Banten.Key words:  raw vegetable pickle, human intestinal parasite, South Tangerang.
PREVALENSI DAN FAKTOR RISIKO TUNGAU DEBU RUMAH DI PAMULANG (TANGERANG) DAN PASAR REBO (JAKARTA) Subahar, Rizal; Widiastuti, Widiastuti; Aulung, Agus
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2016): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1763.736 KB) | DOI: 10.33533/jpm.v10i1.4

Abstract

House dust mites (HDM), anaeroallergen which may be found in all of part of the urban house including mattress. The objectives of this study were to find out the prevalence and risk factors of house dust mites in urban communities i.e.,Pamulang (Southern Tangerang) and Pasar Rebo (Nothern Jakarta). The study design was a cross-sectional study. The samples of house dusts were collected from house of respondents, living-room floors, bed-room floors, kitchen-room floors, terrace-room floors, ventilation, kapuk mattress, sofa, spring bed, foam mattress, and carpet. Mites were examined by a direct method. The species of HDM found were Dermatophagoides pteronyssinus, D.farinae, and Glyciphagus destructor. The prevalence rate ofHDM was 66,9% (621/927). Statistically, no significant difference(p>0,05) was found between the prevalence of HDM in Pamulang(59,8% ,307/513) and Pasar Rebo (75,8%, 314/414). In Pamulang, 94.2% (49/52)of the respondent’s houses were HDM positive (+) and 63.6% (28/44) in Pasar Rebo. Mattresses and bed-room floors were risk factors for HDM(OR=1.99 95% CI 1.06-3.72 and OR=1.8 95% CI 1.10-2.90). This study showed that the houses in two urban communities hadrich HDM.
PREVALENSI DAN INTENSITAS INFEKSI Ascaris lumbricoides DAN Trichuris trichiura PADA ANGGOTA KELUARGA DI JAKARTA DAN CIPANAS, JAWA BARAT Subahar, Rizal; Patiah, Patra; Widiastuti, Widiastuti; Aulung, Agus; Wibowo, Heri
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2017): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (298.64 KB) | DOI: 10.33533/jpm.v11i1.208

Abstract

The infection of Ascaris lumbricoides and Trichiuris trichiura may be occured among family members. The aim ofthe study was to know the prevalence and intensity of A.lumbricoidesand T.trichiurainfections among family members in Jakarta and Cipanas, West Java. This study was conducted in two Government Schools, namely SDN Kalibaru 07 Pagi(North Jakarta) and SDN Tarigu(Cipanas, West Jawa) using a cross-sectional design. The feces samples of respondents consisted of father, mother, schoolchildren, as well as other family members. The feces samples were tested by Kato-Katz method. A total of feces samples examined was 842 samples consisting of 242 samples from Kalibaru and 600 from Cipanas. The feces samples were examined by Kato-Katz method. In Kalibaru the prevalences of A. lumbricoides and T.trichiura in father were 27,8% and 13,9%, mother 32,6% and 7,0%, schoolchildren 37,5% and 36,5%, and other family members 30,5% and 21,1% respectively. Statistically, no significant differentiation (p>0.05) of the prevalences of the intestinal helminths among faher, mother, schoolchildren, and other familiy members in Kalibaru. In Cipanas, the prevalences of A. lumbricoides andT.trichiura in fahter were 0,0% and 4,0%, mother 2,0% and 4,70%, schoolchildren 2,0% and 16,7%, and other family members 0,0% and 4,7%. The intensity of A. lumbricoides and T. trichiura infections among the family members in Kalibaru and Cipanans was light to moderate. The A. lumbricoides high infection was only found among schoolchildren in Kalibaru. The family members infected by A. lumbricoides and T. trichiura were a source of infection for transmitting the intestinal helminths in the community.
Pengaruh Air fermentasi Cucian Beras Sebagai Atraktan ovitrap terhadap Jumlah telur Aedes sp. yang terperangkap di Kecamatan Limo Depok Winita, Rawina; Geraldi, Iskandar Purba; Subahar, Rizal
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 9 No. 2 (2023): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v9i2.1804

Abstract

Aedes aegypti (L.) merupakan vektor yang menularkan penyakit seperti demam berdarah, chikungunya, dan virus zika. Chikungunya merupakan penyakit yang menyebabkan morbiditas dan masih terjadi di kecamatan Limo, Kota Depok pada Juni 2018 lalu. Chikungunya paling baik diatasi melalui pengendalian vektornya. Salah satu upaya pengendalian Ae. aegypti adalah dengan menggunakan perangkap telur nyamuk atau ovitrap. Ovitrap merupakan perangkap telur nyamuk yang menggunakan atraktan untuk menarik nyamuk betina bertelur. Atraktan yang sudah sering digunakan adalah air rendaman jerami namun sulit ditemukan pada keadaan sehari-hari sehingga didapatkan ide untuk memanfaatkan air fermentasi cucian beras sebagai atraktan. Penelitian dilakukan dengan desain penelitian eksperimental analitik pada lingkungan. Variabel yang diamati terdiri dari konsentrasi air fermentasi cucian beras yang terdiri dari konsentrasi 10%, 30%, dan 60% dengan kontrol air PAM . Variabel lain yang diamati adalah lokasi pemasangan di luar dan di dalam rumah. Terhadap Atraktan dilakukan perhitungan parameter kimia dan fisika. Hasil penelitian menunjukkan terdapat perbedaan bermakna antara jumlah telur pada ovitrap kontrol dengan ovitrap konsentrasi 10%, 30% dan 60%. Hasil analisis menunjukkan tidak terdapat hubungan bermakna antara konsentrasi air cucian beras terhadap efektivitas ovitrap akan tetapi, terdapat hubungan yang bermakna antara perletakkan ovitrap terhadap efektivitas ovitrap. Hasil Oviposition activity index menunjukkan konsentrasi 30% berpotensi sebagai atraktan. Suhu, kelembapan, parameter kimia, parameter fisika, dan faktor lainnya mempengaruhi hasil penelitianKata kunci: Ovitrap; Atraktan Nyamuk; Aedes aegypti; Air Fermentasi Cucian Beras
Targeting Detoxifying Enzymes in the Lymphatic Filariasis Vector: An In Silico Study on Curcumin, Camphor, and Menthol Subahar, Rizal; Winita, Rawina; Dwira, Surya; El Bayani, Gulshan Fahmi
Indonesian Journal of Medical Chemistry and Bioinformatics
Publisher : UI Scholars Hub

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Abstract

Vector control remains a critical component in the prevention of lymphatic filariasis, a disease transmitted by insect vectors. Natural compounds such as curcumin, camphor, and menthol are being explored for their bio-insecticidal properties due to their potential to inhibit key detoxification and neurological enzymes in insects, including acetylcholinesterase (AChE), glutathione S-transferase (GST), and cytochrome P450 oxidases (CYP450). A molecular docking study using SwissDock was conducted to evaluate the interaction of curcumin, camphor, and menthol with AChE, GST, and CYP450 enzymes. Binding affinity (ΔG), hydrogen bonding, and active site interactions were analyzed to assess the inhibitory potential of each compound. Curcumin showed the highest binding affinity across all target enzymes. AChE (-8.2 kcal/mol), GST (-7.9 kcal/mol), and CYP450 (-7.5 kcal/mol). It formed strong hydrogen bonds with key catalytic residues, suggesting effective inhibition of neurotoxicity and detoxification pathways. Camphor displayed moderate binding affinities with AChE (-7.1 kcal/mol), GST (-6.5 kcal/mol), and CYP450 (-7.2 kcal/mol), primarily through hydrophobic interactions. Menthol exhibited the weakest binding, with limited hydrogen bonding and lower affinities (AChE: -6.4 kcal/mol, GST:-5.9 kcal/mol, CYP450: -6.3 kcal/mol). The findings suggest that curcumin is a promising candidate for insect vector control through inhibition of critical enzyme systems involved in neurotransmission and detoxification. Camphor may offer moderate bioactivity, while menthol appears less potent. These insights support further exploration of phenolic compounds as environmentally friendly, natural insecticidal agents against vectors of lymphatic filariasis.
Co-Authors Abd. Rasyid Syamsuri Abdulbar Hamid Agus Aulung, Agus Akira Ito Dwira, Surya El Bayani, Gulshan Fahmi Firmansyah, Nurhadi Eko Geraldi, Iskandar Purba Lisawati Susanto Lubis, Nadar Sukri Luh Made Indah Sri Handari Adiputra Luh Putu Ratna Sundari Maemunah, Ade Siti Manan, Widiastuti S Patra Patiah, Patra Rawina Winita Sri S. Margono Suriptiastuti Suriptiastuti, Suriptiastuti Sutisna Himawan Teddy A. Purnama