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Pediatric skull bone defect due to epidermoid cyst Sinurat, Robert; Gultom, Fajar Lamhot
Universa Medicina Vol. 40 No. 1 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.52-56

Abstract

BackgroundTumors of the skull usually affect adult patients and less than twenty percent of pediatric patients. As the tumors grow, the surrounding bone may undergo destruction and erosion. When the tumors are located in the fontanel, the timely closure of the fontanel may be inhibited. Epidermoid cysts are benign tumors that are intracranially located and very rarely in the midline of the cranium. Meanwhile about 32% of stratified-squamous epithelial epidermoid cysts affect the head and neck region and only 6.7% occur in the scalp. We report an unusual epidermoid cyst located and growing in the anterior fontanel of a pediatric patient and inhibiting fontanel closure.Case Description A 21-month-old boy and his parents visited our polyclinic because there was a lump on his anterior fontanel since four months before they came to the hospital. The lump was initially the size of a peanut and had grown to become as large as a quail’s egg. The physical examination was normal and the brain CT-scan showed bone destruction without any intracranial lesion. The tumor was excised on the preoperative diagnosis of dermoid cyst. Histopathology examination showed the characteristics of an epidermoid cyst. The cyst had a wall and was full of keratin flakes without hair follicles or sebaceous glands. Follow-up one year after complete excision did not reveal any recurrence. ConclusionEpidermoid cysts in the skull of pediatric patients must be completely excised as soon as possible because their growth can damage the bone and inhibit the closure of the sutures.
Efektivitas Penggunaan Obat Antihelmintik Secara Massal Terhadap Soil Transmitted Helminths Di Indonesia Sebuah Scoping Article Imanuel, Rizki; Siagian, Forman E.; Sinurat, Robert; Ronny
Majalah Kedokteran UKI Vol. 38 No. 3 (2022): SEPTEMBER - DESEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v38i3.5718

Abstract

Obat anti helmintik digunakan pada infeksi Soil Transmitted Helminths (STH) untuk mengobati dan mencegah terjadinya infeksi berat yang mengakibatkan anemia dan gangguan tumbuh kembang anak. Pemberian obat anti helmintik dapat dilakukan secara berkala sebagai pencegahan terhadap infeksi maupun reinfeksi. Albendazole 400 mg dan Mebendazole 500 mg merupakan obat antihelmintik spektrum luas yang direkomendasikan World Health Organization (WHO) karena efektif, murah, mudah untuk diberikan, dan memiliki efek samping yang kecil. Tujuan penelitian ini adalah untuk mengetahui efektivitas penggunaan antihelmintik secara massal di Indonesia untuk infeksi STH. Studi literatur ini merupakan artikel scoping yang memakai Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Tinjauan literatur ini dibuat melalui penelusuran artikel pada database Pubmed® dan Google Scholar dengan menggunakan kata kunci "parasite infection" OR "worm infection" OR "helminth infection" AND “Soil Transmitted Helminth”. Hasil penelitian menunjukkan bahwa obat yang memiliki efektifitas tinggi dalam pengobatan massal anthihelmintik terhadap infeksi STH adalah Albendazole. Lama pemberian antihemintik yang efektif untuk pemberian obat secara massal terhadap infeksi STH adalah dalam dua minggu dengan sekaligus diadakannya evaluasi secara berkala. Kesimpulan dalam penelitian ini, mebendazole sebagai pengobatan lini pertama memiliki efektifvitas yang lebih baik. Sementara, albendazole dan mebendazole serta pirantel pamoat tetap memiliki efektivitas yang baik terhadap infeksi Ascaris lumbricoides, Trichuris trichiura, dan cacing tambang dengan efektifitas 9% sampai 97%. Kata Kunci: Infeksi parasit, Kecacingan, Albendazol Anti-helminthic drugs are used in soil transmitted helminth (STH) infections to treat and prevent the occurrence of heavy infection that causes anemia and childhood developmental problems. Administration of anti-helminthic drugs could be given periodically as prevention towards infection or reinfection. Albendazole 400 mg and mebendazole 500mg are wide spectrum that are recomended bu the World Health Organization (WHO) because it is effective, affordable, easy to administer, and has minimal side effects. The purpose of this study is to understand the effectivity of mass anti-helminthic drug use in Indonesia for STH infections. This literature study (review) is an article scoping using the Preffered Reporting Items for Systematic Review and Meta Analysis (PRISMA) (pake metode ga si?). This literature review is made by searching for articles in the PubMed and Google Scholar databases by using the keywords "parasite infection" OR "worm infection" OR "helminth infection" AND "soil transmitted helminth". The findings of this study find that the drug that has the highest effectivity in mass antihelminthic administration towards STH infections is albendazole. The duration of effective antihemintic administration for mass drug administration against STH infection is within 2 weeks, with periodic evaluations being held at the same time. The conclusion of this study is mebendazole has better effectivity as a first line drug, while albendazole and mebendazole as well as pyrantel pamoate still have good effectivity against Ascaris lumbricoides, Trichiuris trichiura, and hookworm infections with an effectivity between 9% to 97%. Keywords: parasite infection, worm infection, Soil Transmitted Helminth
Clinical Symptoms and Treatment Outcomes of COVID-19 Patients with Stroke Daud, Oskar Yuda; Sinurat, Robert
Althea Medical Journal Vol 11, No 1 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n1.3120

Abstract

Background: COVID-19 patients who come to the emergency room often suffer from stroke. This study aimed to examine clinical symptoms and treatment outcomes of COVID-19 patients with stroke.Methods: This study was a retrospective study using secondary data from medical records of COVID-19 patients with stroke, hospitalized at the Universitas Kristen Indonesia Hospital, Jakarta, Indonesia for the period 2020–2022. Patients with PCR test positive for COVID-19 who had clinical symptoms of stroke, confirmed by  CT scan showing brain ischemic or hemorrhage were included. Data on gender, age, Glasgow coma scale (GCS), subtype of stroke, severity of COVID-19, and outcome were recorded and analyzed using paired t-test and the Spearman correlation.Results: Of the 49 patients included, 91.8% were over 45 years old and suffered from severe COVID-19. Men were slightly more (51.1%) than women and 93.9% of patients suffered from ischemic stroke. The GCS scores of 46.9% of patients decreased significantly during hospitalization (p=0.02). Most of patients (65.3%) had used non-rebreathing mask (NRM), 10.2% ventilators, and others used nasal cannulas. As many as 46.9% of patients died, 44.9% recovered with neurological deficits, and only 8.2% recovered completely. Interestingly, oxygen delivery devices were significantly correlated with outcome (p=0.00). Patients receiving the antiviral favipiravir had better outcomes compared with those taking remdesivir (p=0.021).Conclusion: The mortality rate for stroke patients with severe COVID-19 is high, and the outcome of patients using NRM or ventilator is worse than patients using nasal cannulas. The antiviral Favipiravir has better outcomes for stroke patients with severe COVID-19.