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Siagian, Forman E.
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Profil dan Prevalensi Blastocystis hominis di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia Ronny; Destifani, Nadia L.; Yuwono, Edho; Siagian, Forman E.; Wahyuningsih, Retno
Majalah Kedokteran UKI Vol. 36 No. 2 (2020): MEI - AGUSTUS
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v36i2.3093

Abstract

Abstrak Blastocystis hominis merupakan emerging disease yang terdistribusi luas di dunia, dengan prevalensi 10% di negara maju hingga 60% di negara berkembang. Perannya sebagai mikroorganisme patogen masih kontroversial. Diduga angka kejadian B. hominis lebih banyak didapatkan pada curah hujan yang rendah dan daerah tropis/ sub-tropis. Penelitian dilakukan untuk mengetahui prevalensi, profil B. hominis di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia, serta hubungan antara angka kejadian infeksi B. hominis dengan curah hujan dan kelembaban pada musim penghujan dan kemarau. Penelitian potong lintang deksriptif berdasarkan data pemeriksaan feses di Laboratorium Parasitologi Fakultas Kedokteran Universitas Kristen Indonesia selama 20 tahun sejak Januari 2000 sampai dengan Desember 2019. Sampel feses diperiksa dari sediaan basah dengan pewarnaan eosin dan lugol, dan hasilnya dilaporkan dengan sistem skoring semi kuantitatif. Data curah hujan dan kelembaban didapatkan dari Badan Meteorologi Klimatologi dan Geofisika Stasiun Meteorologi Kemayoran Jakarta.Didapatkan 3270 sampel, dengan hasil sampel positif B. hominissebanyak 440 sampel (14%), Prevalensi pada perempuan lebih tinggi dibandingkan laki-laki dan terbanyak pada kelompok usia 21-60 tahun (67,4%). Persentase tertinggi ditemukan pada feses dengan konsistensi cair. Tidak ditemukan hubungan antara prevalensi infeksi B. hominis dengan curah hujan (P=0,285) dan kelembaban (P=0,204). Kata kunci: prevalensi, konsistensi, curah hujan, kelembaban, musim Profile and Prevalence of Blastocystis hominis at Parasitology Laboratory, Medical Faculty Universitas Kristen Indonesia Abstract Blastocystis hominis is an emerging disease that is widely distributed in the world, with a prevalence of 10% in developed countries to 60% in developing countries. Its role as a pathogen is still controversial. It is suspected that the incidence of B. hominis is mostly found in low rainfall and tropical/ sub-tropical areas. The study was conducted to determine the prevalence and profile of B. hominis in the Laboratory of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia.and the relationship between incidence of B. hominisinfection with rainfall and humidity in the rainy and dry seasons.This descriptive cross-sectional study was based on fecal examination data at the FK UKI Parasitology Laboratory for 20 years. from January 2000 to December 2019. Stool examination was carried out by making eosin and lugol wet preparations to examine intestinal protozoa, and the results were reported using a semi-quantitative scoring system.Rainfall and humidity data are obtained from the Meteorology, Climatology and Geophysics Agency of the Stasiun MeteorologiKemayoran, Jakarta. As many as3270 samples were obtained, feses with B. hominis positive results was 440 samples (14%). Based on gender, 53.1% of B. hominisinfected were women and most patients were found in the age range from 21 to 60 years (67.4%). The highest percentage was found in watery stool. There was no statistically significant between the prevalence of B. hominis infection with rainfall (p= 0.285) and humidity (p= 0.204). Key words: prevalence, consistency, rainfall, humidity, season
Efektivitas Penggunaan Obat Antihelmintik Secara Massal Terhadap Soil Transmitted Helminths Di Indonesia Sebuah Scoping Article Imanuel, Rizki; Siagian, Forman E.; Sinurat, Robert; Ronny
Majalah Kedokteran UKI Vol. 38 No. 3 (2022): SEPTEMBER - DESEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v38i3.5718

Abstract

Obat anti helmintik digunakan pada infeksi Soil Transmitted Helminths (STH) untuk mengobati dan mencegah terjadinya infeksi berat yang mengakibatkan anemia dan gangguan tumbuh kembang anak. Pemberian obat anti helmintik dapat dilakukan secara berkala sebagai pencegahan terhadap infeksi maupun reinfeksi. Albendazole 400 mg dan Mebendazole 500 mg merupakan obat antihelmintik spektrum luas yang direkomendasikan World Health Organization (WHO) karena efektif, murah, mudah untuk diberikan, dan memiliki efek samping yang kecil. Tujuan penelitian ini adalah untuk mengetahui efektivitas penggunaan antihelmintik secara massal di Indonesia untuk infeksi STH. Studi literatur ini merupakan artikel scoping yang memakai Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Tinjauan literatur ini dibuat melalui penelusuran artikel pada database Pubmed® dan Google Scholar dengan menggunakan kata kunci "parasite infection" OR "worm infection" OR "helminth infection" AND “Soil Transmitted Helminth”. Hasil penelitian menunjukkan bahwa obat yang memiliki efektifitas tinggi dalam pengobatan massal anthihelmintik terhadap infeksi STH adalah Albendazole. Lama pemberian antihemintik yang efektif untuk pemberian obat secara massal terhadap infeksi STH adalah dalam dua minggu dengan sekaligus diadakannya evaluasi secara berkala. Kesimpulan dalam penelitian ini, mebendazole sebagai pengobatan lini pertama memiliki efektifvitas yang lebih baik. Sementara, albendazole dan mebendazole serta pirantel pamoat tetap memiliki efektivitas yang baik terhadap infeksi Ascaris lumbricoides, Trichuris trichiura, dan cacing tambang dengan efektifitas 9% sampai 97%. Kata Kunci: Infeksi parasit, Kecacingan, Albendazol Anti-helminthic drugs are used in soil transmitted helminth (STH) infections to treat and prevent the occurrence of heavy infection that causes anemia and childhood developmental problems. Administration of anti-helminthic drugs could be given periodically as prevention towards infection or reinfection. Albendazole 400 mg and mebendazole 500mg are wide spectrum that are recomended bu the World Health Organization (WHO) because it is effective, affordable, easy to administer, and has minimal side effects. The purpose of this study is to understand the effectivity of mass anti-helminthic drug use in Indonesia for STH infections. This literature study (review) is an article scoping using the Preffered Reporting Items for Systematic Review and Meta Analysis (PRISMA) (pake metode ga si?). This literature review is made by searching for articles in the PubMed and Google Scholar databases by using the keywords "parasite infection" OR "worm infection" OR "helminth infection" AND "soil transmitted helminth". The findings of this study find that the drug that has the highest effectivity in mass antihelminthic administration towards STH infections is albendazole. The duration of effective antihemintic administration for mass drug administration against STH infection is within 2 weeks, with periodic evaluations being held at the same time. The conclusion of this study is mebendazole has better effectivity as a first line drug, while albendazole and mebendazole as well as pyrantel pamoate still have good effectivity against Ascaris lumbricoides, Trichiuris trichiura, and hookworm infections with an effectivity between 9% to 97%. Keywords: parasite infection, worm infection, Soil Transmitted Helminth