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All Journal Journal of Islamic Pharmacy JURNAL FARMASIMED (JFM) Jurnal Kesehatan Tambusai
Mustamin, Faizal
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Management Therapy of ST-Segment Elevation Myocardial Infarction: A Literature Review Novrianti, Irma; Wijaya, Dhani; Mustamin, Faizal; Wijayanti, Sari
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.8989

Abstract

Coronary Heart Disease (CHD) is the cardiovascular disease due to plaque build-up in the coronary artery, reducing the blood follow to the heart. STEMI (ST-segment elevation myocardial infarction) is the CHD due to the ST-segment elevation in 12 and the cardiac marker elevation as Troponin I. The elevation is due to a blockage in the coronary artery, causing the blood perfusion and oxygen supply for the heart to decrease. The objective of the article review is to describe the correct STEMI therapy based on the research findings and references listed in the literary review. This review was made with the study of literature published in 1993-2019. Conclusion: STEMI therapy management is discomfort management and reperfusion therapy. The reperfusion therapy is aimed to recover the myocardial blood flow, to heal the heart, and to reduce the mortality level. The primary coronary artery reperfusion can be administered with the primary percutaneous coronary intervention (PCI). PCI can open a blockage in the coronary artery and has a good effect on the short-term and long-term clinical results. Besides, it reduces the death risk, myocardial infarction, or repetitive stroke. Meanwhile, reperfusion using fibrinolytics is conducted when PCI is unavailable. Moreover, anticoagulant, antithrombotic, and vasodilators are supporting therapies for STEMI patients to reduce chest pain and prevent reinfarction
Testing the Antioxidant Activity of Ethanol Extract on Terap Fruit Seeds (Artocarpus odoratissimus) using the DPPH Method: Uji Aktivitas Antioksidan Ekstrak Etanol Pada Biji Buah Terap (Artocarpus odoratissimus) Menggunakan Metode DPPH Aisya Maulidia; Wijayanti, Sari; Mustamin, Faizal; Ubrusun, Jufri
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2350

Abstract

Plants contain compounds that are classified as secondary metabolites. One of them is terap fruit (Artocarpus odoratissimus). Terap (Artocarpus odoratissimus) is a plant that grows a lot in Kalimantan. Most of the Artocarpus genus have pharmacological properties. One of the benefits of these compounds is as an antioxidant. Antioxidants can remove free radical compounds in the body and prevent the onset of disease. Secondary metabolite compounds found in plants have been isolated and used as components in medicine. The study was intended to determine the antioxidant activity of ethanol extract of terap fruit seeds (Artocarpus odoratissimus) using the DPPH method. The method in this study was quantitative experimental, which included collecting and collecting plants, making simplicia, making extracts from terap seeds (Artocarpus odoratissimus) using 96% ethanol solvent, and for antioxidant activity testing using the DPPH method. The presence of antioxidant compounds in plant extracts can cause a change in the color of DPPH from purple to yellow. This color change will indicate antioxidant activity against DPPH free radicals and is measured by UV-Vis Spectrophotometry. Antioxidant activity was measured using the IC50 value (50% Inhibitory Concentration). From the results of the antioxidant activity test using the DPPH method, it can be concluded that the ethanol extract of terap fruit seeds obtained from the Tarakan area showed antioxidant activity. The IC50 value of 197.45 mg/ml indicates that its antioxidant ability is impaired as a weak antioxidant.
GAMBARAN PENYIMPANAN DAN DISTRIBUSI OBAT DI GUDANG FARMASI RSUD DR. H. JUSUF SK Amanda, Cindy Septiana; Wijayanti, Sari; Mustamin, Faizal
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.43387

Abstract

Kebutuhan masyarakat terhadap pelayanan kesehatan semakin mengalami peningkatan, yang mendorong rumah sakit untuk terus memajukan kualitas pelayanan, termasuk pengelolaan obat. Tujuan  utama penelitian ini untuk menggambarkan kondisi penyimpanan dan distribusi obat di gudang farmasi RSUD Dr. H. Jusuf SK Kota Tarakan sesuai dengan Permenkes No. 72 Tahun 2016. Penelitian menggunakan metode observasi deskriptif yang dilakukan melalui pengumpulan data menggunakan checklist pada bulan Desember 2024. Hasil penelitian menunjukkan jika sebagian besar aspek penyimpanan obat telah memenuhi standar dengan nilai persentase 94,74%. Pada distribusi obat, hasil penelitian mencapai 100% dengan sistem distribusi yang sesuai dengan SOP dan standar pengelolaan farmasi yang baik, termasuk pengawasan kualitas dan penerapan sistem FIFO/FEFO. Berdasarkan hasil penelitian, sistem distribusi obat di Gudang Farmasi RSUD Dr. H. Jusuf SK telah memenuhi standar Permenkes No. 72 Tahun 2016. Namun dalam penyimpanan obat, terutama pemisahan obat LASA masih perlu perbaikan.
IDENTIFIKASI SENYAWA FLAVONOID EKSTRAK ETANOL 96% BATANG PIDADA PUTIH (SONNERATIA ALBA) DENGAN METODE KLT Isnada, Febi; Ubrusun, Jufri; Mustamin, Faizal
Jurnal Kesehatan Tambusai Vol. 6 No. 1 (2025): MARET 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i1.43887

Abstract

Pidada putih (Sonneratia alba) merupakan jenis tanaman mangrove dari keluarga Lythraceae yang tumbuh didaerah tropis dan subtropis tanaman ini juga merupakan rantai makanan di lingkungan perairan dan pesisir Analisis kualitatif bertujuan padakandungan senyawa flavonoid dalam ekstrak etanol dan fraksi metanol batang pidada putih (Sonneratia alba) asal Kabupaten Tana Tidung Provinsi Kalimantan Utara. Metode observasional deskriptif digunakan yakni pengamatan data hasil identifikasi senyawa metabolit sekunder, dengan hasil uji KLT berupa perubahan warna dan nilai faktor reterdasi (Rf). Tanaman yang digunakan telah dideterminasi langsung Badan Riset dan Inovasi Nasional (BRIN) pada bulan Desember tahun 2024. Penelitian ini dilakukan proses ekstraksi melalui proses simplisia. Hasil ekstrak batang pidada putih dilakukan uji kemurnian melalui KLT dengan eluen fase diam plat silica gel G60 F254 dan fase gerak n-heksan:etil asetat 1:3 penyemprotan reagen sitroborat didapatkan bercak noda kuning kecoklatan nilai Rf 0,31 cm dan saat diamati pada sinar uv 366 nm menghasilkan warna noda berflourensi biru terang dengan nilai Rf 0,32 cm. Disimpulkan bahwa ekstraksi batang pidada putih (Sonneratia alba) mengandung flavonoid.
Co-Authors Aisya Maulidia Amanda, Cindy Septiana Dhani Wijaya, Dhani Isnada, Febi Novrianti, Irma Sari Wijayanti Ubrusun, Jufri