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All Journal Majalah Kesehatan Indonesia Farmasis: Jurnal Sains Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Bethasari, Maulidwina
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pengaruh Perbedaan Konsentrasi Polimer HPMC pada Sediaan Patch Transdermal Ekstrak Buah Stroberi (Fragaria vesca L.) Syaputri, Fauzia Ningrum; Bethasari, Maulidwina; Triana, Aldi Muhammad
FARMASIS: Jurnal Sains Farmasi Vol 5 No 1 (2024): Farmasis: Jurnal Sains Farmasi Vol 5. No. 1 (2024)
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v5i1.8746

Abstract

Latar Belakang: Patch transdermal merupakan pengobatan yang ditempelkan pada kulit tanpa menyentuh secara langsung. Hal ini diperlukan dalam pengobatan luka terbuka pada kulit yang rentan terjadinya infeksi oleh bakteri Staphylococcus aureus. Buah stroberi mengandung senyawa flavonoid yang berfungsi untuk menghambat pertumbuhan bakteri Staphylococcus aureus yang dapat menyebabkan infeksi pada luka. Maka dilakukanlah penelitian ekstrak buah stroberi sebagai zat aktif untuk sediaan farmasi patch transdermal. Tujuan: untuk mengetahui karakteristik fisik, menentukan formula sediaan patch ekstrak buah stroberi (Fragaria vesca L.) dengan variasi konsentrasi HPMC sebagai polimer dalam sediaan patch, dan untuk mengetahui aktivitas antibakteri dari patch ekstrak buah stroberi (Fragaria vesca L.) terhadap bakteri Staphylococcus aureus. Metode: Formulasi sediaan patch ekstrak buah stroberi menggunakan variasi konsentrasi HPMC 6, 8, dan 10 persen. Evaluasi terhadap sediaan patch meliputi organoleptis, keseragaman bobot, ketebalan, pH, ketahanan lipat, kelembapan dan stabilitas freeze thaw. Hasil: uji evaluasi diperoleh F1, F2, F3 patch transdermal ekstrak buah stroberi dengan karakteristik fisika dan kimia sediaan yang baik. Kesimpulan:  formula optimum sediaan patch pada formula 3 dengan konsentrasi HPMC 10 persen, dan patch ekstrak buah stroberi (Fragaria vesca L.) tidak memiliki aktivitas antibateri Staphylococcus aureus.
FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF Camellia sinensis KOMBUCHA ETHYL ACETATE EXTRACT AND CREAM FORMULATION Bethasari, Maulidwina; Rahayu, Anis Puji; Safitri, Novis
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 4 (2025): Forthcoming Issue
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i4.1786

Abstract

Kombucha, a fermented tea beverage made using a symbiotic culture of bacteria and yeast (SCOBY), is gaining interest due to its bioactive compounds, particularly flavonoids, which are known for their antioxidant properties. These natural antioxidants, derived from the tea leaves of Camellia sinensis, may offer functional benefits when applied in topical formulations such as creams. This study aimed to determine the flavonoid concentration in kombucha extracts after fermentation for 7 and 14 days and to evaluate the antioxidant activity of a cream formulation containing kombucha extract. Kombucha extract was obtained using a liquid-liquid extraction method with ethyl acetate as the solvent. Antioxidant activity was measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, where a lower IC50 value indicates stronger antioxidant activity. The results showed that The total flavonoid content in the kombucha extract fermented for 7 days (H7) was 125.79 ± 0.192 mg QE/g, while the extract fermented for 14 days (H14) contained 35 ± 0.333 mg QE/g. Antioxidant activity testing revealed IC50 values of 6.84 for the H7 extract and 7.48 for the H14 extract, indicating that the 7-day fermented kombucha had a higher antioxidant potential. These findings suggest that fermentation duration significantly affects the flavonoid content and antioxidant capacity of kombucha extracts, which may influence their efficacy when incorporated into topical formulations, such as creams. This study highlights the potential of kombucha extracts as natural antioxidant agents for cosmetic and pharmaceutical applications. Keywords: antioxidant, Camellia sinensis, flavonoid, kombucha, SCOBY
From Business to Care: An Analysis of Pharmaceutical Service Compliance Across Indonesian Pharmacies Bethasari, Maulidwina
Majalah Kesehatan Indonesia Vol. 7 No. 1 (2026)
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2026275

Abstract

Pharmaceutical services in Indonesian community pharmacies play a critical role in ensuring safe and effective medication use. However, despite the establishment of the Ministry of Health Regulation No. 73 of 2016, significant disparities in compliance persist, which may compromise patient safety and the quality of pharmaceutical care. This study analyzes pharmacy compliance across various regions of Indonesia in implementing pharmaceutical service standards, focusing on three key domains: pharmaceutical supply management, clinical services, and human resources. A total of 43 eligible studies were systematically reviewed and categorized according to the regulatory indicators. The results showed that pharmaceutical supply management demonstrated the highest compliance levels (average 88–94%), as it directly supports pharmacy profitability. In contrast, clinical services such as counseling, Home Pharmacy Care (HPC), and Drug Therapy Monitoring (DTM) exhibited low implementation rates (23–40%), primarily due to limited remuneration and insufficient pharmacist engagement. Only 36.87% of pharmacies conducted self-evaluations, yet these showed significantly higher compliance compared to those that did not. Pharmacist attendance alone did not correlate with improved clinical service provision, indicating that competency and institutional support are more critical determinants of compliance. In conclusion, the findings highlight that Indonesian pharmacies remain largely business-oriented, with clinical services underperformed relative to managerial aspects. Strengthening policy enforcement and professional capacity-building is essential to enhance compliance and support a shift toward patient-centered pharmaceutical care.
Co-Authors Fauzia Ningrum Syaputri, Fauzia Ningrum Rahayu, Anis Puji Safitri, Novis Triana, Aldi Muhammad