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All Journal Cendekia Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Rahayu, Anis Puji
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Medicine & Pharmacology

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AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAN FRAKSI UMBI LOBAK PUTIH (Raphanus Sativus L.) TERHADAP BAKTERI STAPHYLACOCCUS AUREUS SECARA IN VITRO Putri, Nadian Jelita; Lestari, Dwintha; Rahayu, Anis Puji; Tugon, Titian Daru Asmara; Syaputri, Fauzia Ningrum
Cendekia Journal of Pharmacy Vol 8, No 1 (2024): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v8i1.269

Abstract

Umbi lobak putih (Raphanus sativus L.) merupakan salah satu bahan alam yang memiliki senyawa aktif yang dapat berpotensi sebagai antibakteri. Pertumbuhan bakteri patogen yang berlebihan dapat mengakibatkan penyakit berupa infeksi pada tubuh. Dampak negatif dari pertumbuhan bakteri Staphylacoccus aureus dapat menyebabkan infeksi kulit dan saluran pernapasan. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri, KHM dan KBM ekstrak etanol dan fraksi umbi lobak putih terhadap bakteri Staphylacoccus aureus. Aktivitas antibakteri ekstrak etanol dan fraksi umbi lobak putih diujikan menggunakan metode difusi cakram, Konsentrasi Hambah Minimum (KHM) dan Kadar Bunuh Minimum (KBM) ditentukan dengan metode dilusi padat. Hasil penelitian menunjukkan bahwa ekstrak etanol dan fraksi umbi lobak putih dapat menghambat pertumbuhan bakteri lemah pada konsentrasi 40 mg/mL dengan diameter hambatan 9,25 mm pada ekstrak etanol umbi lobak putih, 7,5 mm pada fraksi air, 8,5 mm pada fraksi etil asetat dan tidak terdapat daya hambat pada fraksi n-Heksan. Berdasarkan pengujian KHM dan KBM pada ekstrak etanol umbi lobak putih tidak terdapat nilai KHM dan KBM begitupun dengan fraksi air dan fraksi n-Heksan. Adapun pada fraksi etil asetat terdapat KHM pada konsentrasi 10 mg/mL dan KBM pada konsentrasi 20 mg/mL.
FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF Camellia sinensis KOMBUCHA ETHYL ACETATE EXTRACT AND CREAM FORMULATION Bethasari, Maulidwina; Rahayu, Anis Puji; Safitri, Novis
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 4 (2025): Forthcoming Issue
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i4.1786

Abstract

Kombucha, a fermented tea beverage made using a symbiotic culture of bacteria and yeast (SCOBY), is gaining interest due to its bioactive compounds, particularly flavonoids, which are known for their antioxidant properties. These natural antioxidants, derived from the tea leaves of Camellia sinensis, may offer functional benefits when applied in topical formulations such as creams. This study aimed to determine the flavonoid concentration in kombucha extracts after fermentation for 7 and 14 days and to evaluate the antioxidant activity of a cream formulation containing kombucha extract. Kombucha extract was obtained using a liquid-liquid extraction method with ethyl acetate as the solvent. Antioxidant activity was measured using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, where a lower IC50 value indicates stronger antioxidant activity. The results showed that The total flavonoid content in the kombucha extract fermented for 7 days (H7) was 125.79 ± 0.192 mg QE/g, while the extract fermented for 14 days (H14) contained 35 ± 0.333 mg QE/g. Antioxidant activity testing revealed IC50 values of 6.84 for the H7 extract and 7.48 for the H14 extract, indicating that the 7-day fermented kombucha had a higher antioxidant potential. These findings suggest that fermentation duration significantly affects the flavonoid content and antioxidant capacity of kombucha extracts, which may influence their efficacy when incorporated into topical formulations, such as creams. This study highlights the potential of kombucha extracts as natural antioxidant agents for cosmetic and pharmaceutical applications. Keywords: antioxidant, Camellia sinensis, flavonoid, kombucha, SCOBY
Co-Authors Bethasari, Maulidwina Fauzia Ningrum Syaputri, Fauzia Ningrum Lestari, Dwintha Putri, Nadian Jelita Safitri, Novis Tugon, Titian Daru Asmara