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All Journal Acta Pharmaceutica Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian
Khoirunnisa, Intan
Unknown Affiliation
Health Professions Medicine & Pharmacology

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REVIEW: PENDEKATAN METABOLOMIK DALAM EKSPLORASI TANAMAN ANTIHIPERTENSI: PROFIL SENYAWA BIOAKTIF DAN PERUBAHAN METABOLIT ENDOGEN Khoirunnisa, Intan; Patonah
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25029

Abstract

Metabolomic techniques represent an analytical strategy that supports the discovery of natural product-based drugs, including antihypertensive agents. This article aims to review various metabolomic techniques and approaches used to identify and characterize bioactive compounds in medicinal plants, highlighting two primary strategies: (1) plant metabolite profiling to identify potential bioactive biomarkers, and (2) analysis of endogenous metabolite changes in biological samples from hypertensive models treated with plant-based interventions. Literature was searched through databases such as PubMed and Google Scholar using relevant keywords. This review focuses on analytical methods such as LC-MS, NMR, and HPLC, data processing strategies including PCA, PLS-DA, and OPLS, and the integration of metabolomic techniques in the validation and exploration of plant-derived antihypertensive compounds. The findings demonstrate that metabolomic approaches significantly contribute to accelerating natural drug discovery by identifying biomarkers and elucidating mechanisms of action through related endogenous metabolic pathways. 
Eksplorasi Potensi Antibakteri Senyawa Xanton Dalam Garcinia mangostana L. : Review Khoirunnisa, Intan; Rachmawati, Winasih; Susilawati, Elis
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.36090

Abstract

Xanthone compounds are a group of secondary metabolites commonly found in Garcinia mangostana plants. Several studies have shown that the content of these compounds in mangosteen plants exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. This review aims to summarize various findings related to the antibacterial activity of mangosteen, both in extract form and pure xanthone compounds, as well as their mechanisms. A comprehensive literature search was conducted through PubMed, Mendeley, and Google Scholar databases using relevant keywords. Articles that met the inclusion criteria were reviewed to identify findings related to mangosteen's antibacterial activity. The results showed that several mangosteen extracts with different solvents, such as ethanol, methanol, and n-hexane, exhibited different metabolite profiles and activities against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Among the various xanthone compounds, α-mangostin is the most extensively studied and has shown potential antibacterial activity, although other xanthone metabolites may exhibit similar activity. The antibacterial mechanisms of this compound include membrane damage, increased permeability, and inhibition of biochemical pathways for growth. In conclusion, xanthone compounds have great potential as natural antibacterial candidates, but the exploration of specific metabolites is still limited to α-mangostin, highlighting the need for further exploration of xanthone metabolites and their relationship with antibacterial activity.
Co-Authors Patonah Rachmawati, Winasih Susilawati, Elis