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All Journal Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia
Khoirunnisa, Intan
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Computer Science & IT Medicine & Pharmacology

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REVIEW: PENDEKATAN METABOLOMIK DALAM EKSPLORASI TANAMAN ANTIHIPERTENSI: PROFIL SENYAWA BIOAKTIF DAN PERUBAHAN METABOLIT ENDOGEN Khoirunnisa, Intan; Patonah
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25029

Abstract

Metabolomic techniques represent an analytical strategy that supports the discovery of natural product-based drugs, including antihypertensive agents. This article aims to review various metabolomic techniques and approaches used to identify and characterize bioactive compounds in medicinal plants, highlighting two primary strategies: (1) plant metabolite profiling to identify potential bioactive biomarkers, and (2) analysis of endogenous metabolite changes in biological samples from hypertensive models treated with plant-based interventions. Literature was searched through databases such as PubMed and Google Scholar using relevant keywords. This review focuses on analytical methods such as LC-MS, NMR, and HPLC, data processing strategies including PCA, PLS-DA, and OPLS, and the integration of metabolomic techniques in the validation and exploration of plant-derived antihypertensive compounds. The findings demonstrate that metabolomic approaches significantly contribute to accelerating natural drug discovery by identifying biomarkers and elucidating mechanisms of action through related endogenous metabolic pathways. 
Geographical Characterization of West Java Clove by FTIR and Chemometrics PCA Analysis Rachmawati, Winasih; Khoirunnisa, Intan; Asnawi, Aiyi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.61029

Abstract

Clove is a plant native to West Java, Indonesia, and its composition has been scientifically proven to have antioxidant, antibacterial, antinociceptive, and cytotoxic effects. The quality of a plant is influenced by its growth location, harvest time, and genetic attributes. This study was designed to determine the characteristics of the cloves from West Java. This study aimed to develop a clove fingerprint profile using Fourier transform infrared (FTIR) spectroscopy and principal component analysis (PCA) chemometrics across five regions of West Java. Clove flowers were collected from Bandung, Bogor, Purwakarta, Cianjur, and Tasikmalaya, Indonesia. The cloves were then extracted by maceration with 96% ethanol for three 24-hour periods. The extract was analyzed by FTIR over 4000-650 cm-1 and then subjected to preprocessing steps, including smoothing, differentiation, and Standard Normal Variate. A cumulative PC value of 91% formed three clusters with similar qualities in the score plot: Group 1 (Purwakarta), Group 2 (Bandung, Cianjur, and Tasikmalaya), and Group 3 (Bogor). Chemometric analysis can be used to authenticate and classify cloves based on geographical distribution.
Co-Authors Aiyi Asnawi Patonah Winasih Rachmawati