Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian
Khoirunnisa, Intan
Unknown Affiliation
Computer Science & IT Health Professions Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
REVIEW: PENDEKATAN METABOLOMIK DALAM EKSPLORASI TANAMAN ANTIHIPERTENSI: PROFIL SENYAWA BIOAKTIF DAN PERUBAHAN METABOLIT ENDOGEN Khoirunnisa, Intan; Patonah
Acta Pharmaceutica Indonesia Vol. 50 No. 2 (2025)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v50i2.25029

Abstract

Metabolomic techniques represent an analytical strategy that supports the discovery of natural product-based drugs, including antihypertensive agents. This article aims to review various metabolomic techniques and approaches used to identify and characterize bioactive compounds in medicinal plants, highlighting two primary strategies: (1) plant metabolite profiling to identify potential bioactive biomarkers, and (2) analysis of endogenous metabolite changes in biological samples from hypertensive models treated with plant-based interventions. Literature was searched through databases such as PubMed and Google Scholar using relevant keywords. This review focuses on analytical methods such as LC-MS, NMR, and HPLC, data processing strategies including PCA, PLS-DA, and OPLS, and the integration of metabolomic techniques in the validation and exploration of plant-derived antihypertensive compounds. The findings demonstrate that metabolomic approaches significantly contribute to accelerating natural drug discovery by identifying biomarkers and elucidating mechanisms of action through related endogenous metabolic pathways. 
Eksplorasi Potensi Antibakteri Senyawa Xanton Dalam Garcinia mangostana L. : Review Khoirunnisa, Intan; Rachmawati, Winasih; Susilawati, Elis
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.36090

Abstract

Xanthone compounds are a group of secondary metabolites commonly found in Garcinia mangostana plants. Several studies have shown that the content of these compounds in mangosteen plants exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. This review aims to summarize various findings related to the antibacterial activity of mangosteen, both in extract form and pure xanthone compounds, as well as their mechanisms. A comprehensive literature search was conducted through PubMed, Mendeley, and Google Scholar databases using relevant keywords. Articles that met the inclusion criteria were reviewed to identify findings related to mangosteen's antibacterial activity. The results showed that several mangosteen extracts with different solvents, such as ethanol, methanol, and n-hexane, exhibited different metabolite profiles and activities against Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Among the various xanthone compounds, α-mangostin is the most extensively studied and has shown potential antibacterial activity, although other xanthone metabolites may exhibit similar activity. The antibacterial mechanisms of this compound include membrane damage, increased permeability, and inhibition of biochemical pathways for growth. In conclusion, xanthone compounds have great potential as natural antibacterial candidates, but the exploration of specific metabolites is still limited to α-mangostin, highlighting the need for further exploration of xanthone metabolites and their relationship with antibacterial activity.
Geographical Characterization of West Java Clove by FTIR and Chemometrics PCA Analysis Rachmawati, Winasih; Khoirunnisa, Intan; Asnawi, Aiyi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.61029

Abstract

Clove is a plant native to West Java, Indonesia, and its composition has been scientifically proven to have antioxidant, antibacterial, antinociceptive, and cytotoxic effects. The quality of a plant is influenced by its growth location, harvest time, and genetic attributes. This study was designed to determine the characteristics of the cloves from West Java. This study aimed to develop a clove fingerprint profile using Fourier transform infrared (FTIR) spectroscopy and principal component analysis (PCA) chemometrics across five regions of West Java. Clove flowers were collected from Bandung, Bogor, Purwakarta, Cianjur, and Tasikmalaya, Indonesia. The cloves were then extracted by maceration with 96% ethanol for three 24-hour periods. The extract was analyzed by FTIR over 4000-650 cm-1 and then subjected to preprocessing steps, including smoothing, differentiation, and Standard Normal Variate. A cumulative PC value of 91% formed three clusters with similar qualities in the score plot: Group 1 (Purwakarta), Group 2 (Bandung, Cianjur, and Tasikmalaya), and Group 3 (Bogor). Chemometric analysis can be used to authenticate and classify cloves based on geographical distribution.
Co-Authors Aiyi Asnawi Patonah Rachmawati, Winasih Susilawati, Elis