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All Journal Jurnal Ilmiah Farmasi Usadha Journal of Pharmacy
Prabowo, Muhammad Hatta
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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BIOMARKER DISCOVERIES AND POTENTIAL BIOMARKERS IN LUNG CANCER : A NARRATIVE REVIEW Mahendra, Andika Dwi; Prabowo, Muhammad Hatta; Prawiningrum, Aisyah Fitriannisa
Usadha Journal of Pharmacy Vol. 2 No. 4 (2023): November
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v2i4.167

Abstract

Lung cancer is the second most common cause of death worldwide after breast cancer. This is associated with late diagnosis, which reduces the survival rate. Early diagnosis is one approach that may be employed to improve outcome for the patient with lung cancer. When a small level of cancer is present in the body, a biomarker can be utilized as a diagnostic marker. Liquid biopsy is minimal invasive which can be done to obtain multi-biomarkers in lung cancer. In this article, we will discuss and explore about potential biomarkers for lung cancer early diagnosis.
Gold nanoparticles as drug nanocarriers: therapeutic applications, safety, and translational challenges Salsadila, Ummu; Prabowo, Muhammad Hatta; Istikharah, Rochmy
Jurnal Ilmiah Farmasi Vol. 22 No. 2 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss2.art14

Abstract

Background: Gold nanoparticles (AuNPs) are promising drug nanocarriers due to tunable physicochemical properties, surface functionalization, colloidal stability, and biological interactions. These characteristics may improve drug delivery and therapeutic efficacy.Objective: This review aimed to evaluate AuNP-drug conjugation strategies, therapeutic applications, safety profiles, and challenges that remain for clinical implementation. Methods: A narrative review was performed using PubMed. This review summarized the in vitro and in vivo studies published in English from 2014 to 2025 on AuNP loading or conjugation with drugs. We excluded reviews, conference abstracts, duplicate studies, and studies that did not have relevant therapeutic or safety outcomes.Results: AuNP-based systems exhibit superior therapeutic efficacy in antibacterial, antiviral, antifungal, antidiabetic, and anticancer applications. The effects are associated with enhanced stability of the drug, cellular uptake, accumulation at the target site, controlled release, membrane disruption, and modulation of oxidative stress. Efficacy and safety are affected by particle size, morphology, surface charge, coating, and functionalization. However, differences in synthesis, characterization, experimental models, toxicity assessment, biodistribution, and clearance limited comparison among studies.Conclusion: AuNPs are versatile nanocarriers with high therapeutic potential, but standardization of the production processes, long-term safety evaluation, and regulatory guidelines are still required.
Co-Authors Mahendra, Andika Dwi Prawiningrum, Aisyah Fitriannisa Rochmy Istikharah Salsadila, Ummu