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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) BioEksakta : Jurnal Ilmiah Biologi Unsoed
Adrir, Mutia Syarifah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Aktivitas Enzimatik Isolat Trametes spp. dari Kebun Raya Baturraden dalam Pewarna Batik dengan Variasi Konsentrasi Indigosol Blue Glukosa Adrir, Mutia Syarifah; Dewi, Ratna Stia; Sari, Ajeng Arum
BioEksakta : Jurnal Ilmiah Biologi Unsoed Vol 2 No 2 (2020): BioEksakta
Publisher : Fakultas Biologi Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.bioe.2020.2.2.1810

Abstract

Indigosol Blue merupakan salah satu zat warna sintetik Antraquinon yang digunakan sebagai pewarna biru pada industri pencelupan tekstil dan bersifat rekalsitran dan non-biodegradable, sehingga tidak mudah rusak oleh perlakuan kimia maupun fotolitik. Isolat Trametes sp. diyakini memiliki kemampuan mentransformasi komponen pewarna melalui mekanisme degradasi enzimatik. Trametes sp. mampu menghasilkan enzim ekstraseluler ligninolitik yang dapat mendegradasi komponen xenobiotik dalam limbah pewarna indigosol menjadi bentuk yang tidak toksik di lingkungan. Penelitian bertujuan untuk mengetahui kemampuan tiga isolat uji dalam menghasilkan enzim dalam pewarna Indigosol Blue pada konsentrasi glukosa berbeda serta mengetahui isolat dengan konsentrasi glukosa optimum yang memiliki aktivitas enzim terbaik dalam pewarna Indigosol Blue. Pengukuran aktivitas enzimatik dilakukan dengan metode spektrofotometri. Hasil penelitian menunjukkan bahwa isolat-isolat uji dapat menghasilkan enzim dalam pewarna Indigosol Blue pada konsentrasi glukosa berbeda. Aktivitas enzim pada masing-masing perlakuan berbeda-beda dan menunjukkan hasil yang signifikan. Data uji lanjut memperlihatkan bahwa isolat Trametes sp. strain A memiliki aktivitas enzim terbaik dalam pewarna Indigosol Blue dengan konsentrasi glukosa 0,5%. Penelitian juga menunjukkan bahwa konsentrasi glukosa di atas 0.5% dapat menghambat aktivitas lakase, sehingga aktivitas lakase dalam zat pewarna rendah. Kata kunci: enzim ligninolitik, fungi, glukosa, Indigosol Blue, Trametes sp.
Genetic Variation and Antifungal Susceptibility Profile of Candida auris Adrir, Mutia Syarifah; Setianingrum, Findra; Adawiyah, Robiatul; Hasyim, Ammar Abdurrahman; Rozaliyani, Anna
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.1-13

Abstract

Candida auris is an invasive yeast that has spread worldwide since it was first identified in Japan in 2009. C.auris has spread through four genetic clades that emerged between 2008 and 2013 and caused nosocomial outbreaks. The mortality rates of C.auris infections vary significantly between regions, ranging from 30 to 60%. C.auris infections can cause fungemia, invasive candidiasis, and spread to various organs. C.auris has a defense mechanism against the innate immune response and virulence factors that are not fully understood. High thermal and salinity tolerance, excretion of protease enzymes, and the ability to form biofilms are the main virulence factors that influence the pathogenicity of C.auris. Due to limited facilities, the diagnosis of C.auris infections is still hampered in some countries. Accurate strain identification methods are essential to prevent the rapid spread of this pathogen. Molecular techniques, including PCR and sequencing of the D1/D2 region of 28s rDNA or internal transcribed spacer using specific primers, are recommended for faster and more accurate identification. Genetic analysis revealed single-nucleotide polymorphisms (SNPs) that differed between clades, especially in the nuclear and mitochondrial genomes. C.auris exhibits high resistance to fluconazole, amphotericin B, and echinocandins, with some strains being resistant to all three. Resistance mechanisms include ERG11 gene mutations, Erg11p overexpression, and efflux pump activity. The rise of multidrug-resistant strains and high genetic variation complicates infection management, requiring heightened attention to prevent further spread.
Co-Authors Anna Rozaliyani Hasyim, Ammar Abdurrahman Ratna Stia Dewi Robiatul Adawiyah Sari, Ajeng Arum Setianingrum, Findra