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All Journal Biology, Medicine, & Natural Product Chemistry Budapest International Research in Exact Sciences (BirEx Journal)
Jeff, Iteku Bekomo
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Medicine & Pharmacology Physics Public Health Transportation

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Antisickling and Antibacterial Activities of Anthocleista schweinfurthii Gilg. (Gentianaceae) from Non-human Primates Pharmacopoeia in Democratic Republic of the Congo Ngunde-te-Ngunde, Samy; Lengbiye, Emmanuel Moke; Joseph, Tshidibi Dipa; Franck, Kengo Velantia; Djolu, Ruphin D.; Mesango, Colette Ashande; Gbolo, Benjamin Z.; Jeff, Iteku Bekomo; Mpiana, Pius Tshimankinda; Ngbolua, Koto-te-Nyiwa
Budapest International Research in Exact Sciences (BirEx) Journal Vol 1, No 3 (2019): Budapest International Research in Exact Sciences, July
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v1i3.345

Abstract

The aim of the present study was to evaluate the Chemical composition and bioactivity of Anthocleista schweinfurthii Gilg (Gentianaceae) fruits, leaves, root bark and stem bark extracts against Sickle cell disease (SCD) and associated bacteria. The antisickling and antibacterial activities were carried out using Emmel and micro-dilution methods respectively. The results revealed that the fruits, leaves, root bark and stem bark extracts  of A. schweinfurthii contains various secondary metabolites such as the alkaloids, saponins, total polyphenols, flavonoids, tannins, anthocyanis, leuco-anthocyanins and quinones.  The ethyl acetate and methanol extracts displayed antisickling activity. While, the antibacterial activity of different plant extracts tested was weak toward tested bacterial strains (CMI ≥125μg/mL). The antibacterial activity can be improved by bio-guided fractionation of the n-hexane, ethyl acetate or methanol soluble fraction. This study provides for the first time a scientific basis for the in vitro antisickling activity of A. schweinfurthii.
Nutritional Value Assessment of Marasmiellus inoderma Sporophores Cultivated on Maize Cobs and Coffee Grounds Gertrude, Mbumbu Luswamu; Alain, Tshisuaka Nkongolo; Carmelle, Dibaluka Nlandu; Mawunu, Monizi; Jeff, Iteku Bekomo; Joseph, Lumande Kasali; Justin, Mundele Mukongo; Ngbolua, Koto-Te-Nyiwa; Simon, Dibaluka Mpulusu; Félicien, Lukoki Luyeye
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1459-1467

Abstract

The Democratic Republic of Congo possesses significant agricultural potential, yet its population faces food insecurity, malnutrition, and limited access to essential foodstuffs, resulting in famines in several provinces. This study conducted a comparative analysis of yields and protein content in Marasmiellus inoderma sporophores cultivated on maize cobs and coffee grounds, as well as those collected from the wild. Experiments were carried out at four sites: the Luki Biosphere Reserve (Kongo Central), the experimental garden, the soil laboratory, and the myciculture laboratory. Average yields after four flushes were 31.7 % on maize cobs and 28.23 % on coffee grounds. Protein content was higher in sporophores cultivated on maize cobs (29.37 %) than on coffee grounds (24.98 %), with laboratory-grown samples consistently exhibiting greater protein levels than wild-collected sporophores. These results indicate that cultivating M. inoderma on locally available agro-industrial substrates offers a promising strategy to enhance food security and reduce malnutrition in the DRC, with strong potential for dissemination among both urban and rural producers.
Co-Authors Alain, Tshisuaka Nkongolo Carmelle, Dibaluka Nlandu Djolu, Ruphin D. Félicien, Lukoki Luyeye Franck, Kengo Velantia Gbolo, Benjamin Z. Gertrude, Mbumbu Luswamu Joseph, Lumande Kasali Joseph, Tshidibi Dipa Justin, Mundele Mukongo Lengbiye, Emmanuel Moke Mawunu, Monizi Mesango, Colette Ashande Mpiana, Pius Tshimankinda Ngbolua, Koto-te-Nyiwa Ngunde-te-Ngunde, Samy Simon, Dibaluka Mpulusu