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All Journal Jurnal Kedokteran Diponegoro Jurnal NERS JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH
Firdha, Azizah Amimathul
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Health Professions Medicine & Pharmacology Nursing Public Health

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CASE REPORT: UNCONTROLLED HYPERTENSION CONTRIBUTES TO WORSENING OF PRESBYCUS SYMPTOMS IN THE ELDERLY Saputri, Faradila Budi; Firdha, Azizah Amimathul; Rahma, Safira; Alda, Rieza Rizqy; Inayasari, Syahwina; Purnami, Nyilo
Journal of Community Medicine and Public Health Research Vol. 1 No. 1 (2020): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.688 KB) | DOI: 10.20473/jcmphr.v1i1.20298

Abstract

Presbycusis is a disease that can befall the elderly, caused by a multifactorial process that should be allowed to disrupt communication and social life and cause mental disorders. According to WHO the proportion of the elderly population rises rapidly which is estimated in 2025, there are about 1,2 billion elderly people with a risk of presbycusis. Mr.S was 84 years old, married and had 2 children, complained of hearing loss since 10 years ago on the patient's left ear. The decline in hearing occurred gradually, giving the last 4 years after his wife's death. Patients was taken to Otorhinolaryngologist and expressed age-related hearing impairment and was advised to use hearing aids. Patients are not routinely using hearing aids. In addition, patients have hypertension and heart disease. Patients consumed Captopril 2x1 tablets, Fundifar 2x1, Furosemide 1x40 mg and Fargoxin 1x0.25 mg. Patients do not routinely consumed cardiac medicine and used hearing aids. From the results of heteroanamnesis, physical examination, and audiogram examination conducted in Mr.S patients, it can be concluded that Mr.S suffers from presbycusis with hypertensive and congestive heart failure. Mr.S was advised to routinely have their hearing check to Otorhinolaryngologist the as an evaluation and routine control to Cardiologist. 
The Role of Midazolam on Status Epilepticus: Systematic Review Firdha, Azizah Amimathul; Puspamaniar, Vania Ayu; Machin, Abduloh
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.38806

Abstract

Background: Status epilepticus is a condition that results either in the failure of the mechanisms responsible for stopping seizures or in initiating mechanisms that cause seizures to be abnormally prolonged. Benzodiazepine is the first-line therapy for status epilepticus. The three usually used Benzodiazepines are Lorazepam, diazepam, and midazolam. Objective: This systematic review was undertaken to determine midazolam's role in managing patients with status epilepticus. Methods: A systematic search from PubMed, Science Direct, and Cochrane was conducted with predetermined keywords. Studies in randomized controlled trials assessing the impact of midazolam on epileptic status were included in the inclusion criteria. Articles are published in English, and the full text is accessible. The authors independently extracted data and assessed the risk of bias for each included study. Results: Of 6410 studies obtained from the search results, 13 studies were found that were relevant and matched the inclusion criteria. Benzodiazepines are the first line of SE therapy in an emergency. This group works by inhibiting GABA receptors and has a rapid effect in stopping seizures. Midazolam can be given intravenously, intramuscularly, or transmucosal (nasal, buccal, or rectal). Intravenous midazolam may be a good choice because of its short onset of action and, therefore, can effectively stop seizures. Conclusion: Effective and safe results have been seen with each Midazolam administration method. This suggests that Midazolam may be an excellent therapeutic option for SE. However, the type of Midazolam administration can be adjusted according to the guidelines and drug availability in each country. 
Potential effect of green tea extract for adjuvant treatment of acute ischemic stroke by s100íŸ upregulation in non-thrombolysis patient Machin, Abdulloh; Suprapto, Djoko Agus; Hanifah, Anny; Suharjanti, Isti; Shodiq, Jakfar; Fatihuddin, M Fata; Kim, Beom Joon; Firdha, Azizah Amimathul
Jurnal Ners Vol. 18 No. 2 (2023): JUNE 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v18i2.45537

Abstract

Introduction: In ischemic stroke, the cerebral cortex suffers from hypoxia-ischemia, leading to inflammation and oxidative stress. Green tea extract has an anti-inflammation effect and antioxidant. This study aimed to determine the efficacy of green tea extract for adjuvant treatment of acute ischemic stroke in non-thrombolysis patients. Methods: A double-blind randomised controlled trial was conducted in November 2020-November 2021. The subjects were all acute ischemic stroke patients who presented to the Emergency Room during recruitment, randomised into control (n=13) and intervention groups (n=18); the intervention groups were given green tea extract 350 mg. Treatment was for 30 days. National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Montreal Cognitive Assessment - Indonesia (MoCAIna), IL-10 and S100íŸ were analysed. Results: Data were compared with a significance level of p<0.05. The differences in NIHSS from day 0 to 7, day 0 to 14 and day 0 to 30 were statistically significant in the intervention group (p=0.019, p=0.002 and p=0.000, respectively). The mRS score was statistically significant in the intervention group on day 30 (p=0.46). The differences in mRS score from day 0 to 14 and day 0 to 30 were statistically significant (p=0.042 and p=0.001, respectively) The S100íŸ were statistically significant in day 7 (p=0.006). The difference in S100íŸ from day 0 to 7 was statistically significant (p=0.001).Conclusions: The green tea extract, through up-regulation S100íŸ, can improve the clinical outcomes of acute ischemic stroke.
Co-Authors Alda, Rieza Rizqy Fatihuddin, M Fata Hanifah, Anny Inayasari, Syahwina Kim, Beom Joon Machin, Abdulloh Machin, Abduloh Nyilo Purnami Puspamaniar, Vania Ayu Rahma, Safira Saputri, Faradila Budi Shodiq, Jakfar Suharjanti, Isti Suprapto, Djoko Agus