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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Folia Medica Indonesiana
Asmaningsih, Ninik
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Effects of Atorvastatin on Lipid Profiles and CETP (Cholesteryl Ester Transfer Protein) Levels in Pediatric Patients with Refractory Nephrotic Syndrome Pondawinata, Marizki; Yulistiani; Asmaningsih, Ninik
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.13734

Abstract

Atorvastatin is one of the statin groups indicated for curing and healing in pediatric with hyperlipidemia because it has high potential and safe with  less drug side effects. Several studies have reported the impact of atorvastatin on CETP levels, however the findings remain inconclusive. This study aimed to assess the effect of atorvastatin on lipid profiles and CETP levels in pediatrics patients with refractory nephrotic syndrome and hyperlipidemia. A double-blind, randomized clinical trial (RCT) using pre- and post- test design was conducted over for 4 weeks, involving the treatment group (atorvastatin) and the control group (placebo). The research took place at the pediatric nephrology outpatient clinic of Dr. Soetomo Hospital from December 2019 to March 2020. Baseline assessments at week 0 included measurements of total cholesterol, LDL, HDL, TG, CETP, and other laboratory parameters. Follow-up testing was performed after 4 weeks. The difference in average total cholesterol and LDL at week 0 and week 4 in the control group and the treatment group was significant (p <0.05). Giving atorvastatin reduced total cholesterol (29.2%), LDL cholesterol (30.8%), TG level (7.5%), and did not yet have an increase in HDL cholesterol levels. The mean CETP level in the treatment group were not significant differences despite a decrease in CETP level of 8%. Patients giving atorvastatin showed a relationship between changes in CETP level with LDL level and total cholesterol. These findings suggest that atorvastatin significantly lowers total cholesterol, LDL, and CETP levels in pediatric refractory nephrotic syndrome with hyperlipidemia.
Analysis of High Dose and Long-Term Prednisone Therapy on Trap 5B Level Change in Children with Steroid Sensitive Nephrotic Syndrome Setyani, Dessy Surya; Qibtiyah, Mariyatul; Asmaningsih, Ninik; Yulistiani, Yulistiani
Folia Medica Indonesiana Vol. 54, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Nephrotic syndrome is a condition which is characterized by protein leakage from the blood to the urine through glomeruli. It leads to hypoproteinemia and generalised oedema. Patients with nephrotic syndrome need high dose and long term glucocorticoid such as prednisone. High dose and long term glucocorticoid can increase bone resorption. Biological marker is a valuable tool to evaluate efficacy of therapy. TRAP 5B is a sensitive biological marker for bone resorption because it reflects the number of osteoclasts. TRAP 5B is not affected by renal dysfunction and food. It also has a low diurnal variation than other bone resorption marker. The aim of this study was to analyze the changes of TRAP 5B levels at induction and alternate phase in children with steroid sensitive nephrotic syndrome. This observational prospective study was conducted from May to October 2016. Venous blood samples obtained at 08.00-10.00 am. TRAP5B levels were measured before and after induction phase and after alternate phase using ELISA. Fifteen patients were included in this study (60% boys). Majority of their age was 6 - <12 years and 40% were dependent steroid NS. TRAP 5B serum levels in induction phase increased by 37.41%±56.22%. In alternate phase, TRAP 5B serum levels increased by 28.75%±66.55% compared to the induction phase. However, the level change of both phases were not significant. As a conclusion, TRAP 5B levels increased in induction and alternate phase after high dose and long-term prednisone treatment in nephrotic syndrome.
Co-Authors Mariyatul Qibtiyah Pondawinata, Marizki Setyani, Dessy Surya Yulistiani Yulistiani Yulistiani, Yulistiani