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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Jurnal Indonesia Sosial Sains Gunung Djati Conference Series Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Yulistiani
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OLANZAPINE FOR NAUSEA AND VOMITING IN VARIOUS ETIOLOGIES : A REVIEW Kuswandi, Nabila Aulia Yasmin; Yulistiani
Pharmaceutical Journal of Indonesia Vol. 8 No. 2 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.008.02.1

Abstract

Nausea is an unpleasant response followed by the risk of vomiting that results rapid forced ejection of gastric substance from the stomach upwards and out of the mouth. The Gastrointestinal tract, vestibular system, and thalamus are the sites that cause this event. Serotonin type 3 (5-HT3), Mu, neurokinin-1 (NK-1), kappa opioids, dopamine type 2 (D2) are CTZ receptors that cause emesis. 5-HT3 antagonists, antihistamines, and phenothiazines are common antiemetic agents. Olanzapine is an atypical antipsychotic second-generation medication with antiemetic properties. The article review method involves searching the database for various research articles. The activity of olanzapine with several receptors associated with nausea and vomiting suggests that it may have antiemetic activity. Olanzapine inhibits the 5-HT2C receptor, which is located near small intestine enterochromaffin cells and is required for the emetic response. In CINV therapy, research suggests combining olanzapine 10 mg with a 5-HT3 antagonist, NK-1 antagonist, dexamethasone. Low dose olanzapine at 5 mg is used in hyperemesis gravidarum.
OLANZAPINE FOR NAUSEA AND VOMITING IN VARIOUS ETIOLOGIES : A REVIEW Kuswandi, Nabila Aulia Yasmin; Yulistiani
Pharmaceutical Journal of Indonesia Vol. 8 No. 2 (2023)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2023.008.02.1

Abstract

Nausea is an unpleasant response followed by the risk of vomiting that results rapid forced ejection of gastric substance from the stomach upwards and out of the mouth. The Gastrointestinal tract, vestibular system, and thalamus are the sites that cause this event. Serotonin type 3 (5-HT3), Mu, neurokinin-1 (NK-1), kappa opioids, dopamine type 2 (D2) are CTZ receptors that cause emesis. 5-HT3 antagonists, antihistamines, and phenothiazines are common antiemetic agents. Olanzapine is an atypical antipsychotic second-generation medication with antiemetic properties. The article review method involves searching the database for various research articles. The activity of olanzapine with several receptors associated with nausea and vomiting suggests that it may have antiemetic activity. Olanzapine inhibits the 5-HT2C receptor, which is located near small intestine enterochromaffin cells and is required for the emetic response. In CINV therapy, research suggests combining olanzapine 10 mg with a 5-HT3 antagonist, NK-1 antagonist, dexamethasone. Low dose olanzapine at 5 mg is used in hyperemesis gravidarum.
KEPEMIMPINAN ETIS SEBAGAI STRATEGI TRANSFORMASIONAL DALAM MENINGKATKAN DAYA SAING UMKM KONVENSIONAL DAN SYARIAH Yulistiani
Gunung Djati Conference Series Vol. 56 (2025): Seminar Nasional Ekonomi dan Bisnis Islam
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Usaha Mikro, Kecil, dan Menengah (UMKM) merupakan sektor strategis dalam perekonomian Indonesia yang berkontribusi besar terhadap penciptaan lapangan kerja dan pertumbuhan ekonomi nasional. Namun, UMKM menghadapi berbagai tantangan, terutama dalam aspek kepemimpinan dan pengembangan budaya organisasi yang mendukung keberlanjutan usaha. Salah satu pendekatan yang dinilai efektif untuk mengatasi masalah tersebut adalah penerapan kepemimpinan etis sebagai strategi transformasional. Kepemimpinan etis dianggap mampu membangun budaya organisasi positif, meningkatkan motivasi karyawan, serta loyalitas pelanggan sehingga mendorong pertumbuhan usaha yang berkelanjutan. Penelitian ini mengkaji peran kepemimpinan etis dalam meningkatkan daya saing UMKM konvensional dan syariah di Indonesia dengan menggunakan metode deskriptif kualitatif berbasis studi literatur dari berbagai sumber akademik dan laporan resmi. Hasil kajian menunjukkan bahwa UMKM konvensional lebih menitikberatkan pada efisiensi dan profitabilitas, sedangkan UMKM syariah berlandaskan prinsip kejujuran, keadilan, dan tanggung jawab sosial sesuai nilai Islam. Kesimpulannya, kepemimpinan etis sebagai strategi transformasional dapat meningkatkan daya saing UMKM dengan menyesuaikan karakteristik dan nilai-nilai yang dianut oleh masing-masing jenis UMKM. Studi ini diharapkan memberikan kontribusi teoritis dan praktis bagi pengembangan UMKM di Indonesia.
Analisis Kebijakan Kampung Kb Sebagai Upaya Penanggulangan Kemiskinan Di Kota Cirebon Siti Khumayah; Dharliana Hardjowikarto; Yulistiani
Jurnal Indonesia Sosial Sains Vol. 1 No. 03 (2020): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v1i03.34

Abstract

Tujuan Penelitian untuk mengetahui Implementasi Kebijakan kampung KB DPPKB guna penanggulangan kemiskinan di Kecamatan Lemahwungkuk Kota Cirebon. Metode Penelitian menggunakan deskriptif dengan pendekatan kualitatif dengan tujuan untuk menganalisis secara komprehensif dan mendalam tentang kebijakan Kampung KB di Dinas Pengendalian Penduduk Keluarga Berencana Khususnya di Kecamatan Lemahwungkuk Kota Cirebon. Hasil dari Keberhasilan kebijakan program kampung KB      diantaranya komitmen sumber daya manusia dan pendanaan yang komitmen pada tujuan tercapainya keberhasilan kebijakan untuk kesejahteraan masyarakat. Kelengkapan sarana prasarana pun menunjang keberhasilan program ini dan akan terus ditingkatkan oleh DPPKB dalam pencapaian sumber-sumber kebijakan, karakteristik, badan pelaksana dan kondisi ekonomi, sosial masyarakat serta kondisi politik yang ada. Tingkat sosial ekonomi pun mulai terlihat peningkatan dari jumlah konsumsi penduduk yang berkurang dan lebih dialokasikan kepada konsumsi yang lebih berkualitas seperti makan makanan yang bergizi tercukupi dikarenakan kebutuhan rumah tangga lebih ringan.
Scoping Review: Pola Penggunaan Antipsikotika Pada Pasien Skizofrenia Paranoid Cotama, Cahana Rastra; Yulistiani
Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Vol. 12 No. 2 (2025): October
Publisher : Faculty of Pharmacy, Widya Mandala Surabaya Catholic University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v12i2.7330

Abstract

Paranoid schizophrenia has a better prognosis than other forms. The main sign of paranoid schizophrenia is having strong delusions or auditory hallucinations. This review article is prepared to study the patterns of antipsychotic treatment in schizophrenia patients. The literature sources include PubMed and Google Scholar over the past decade. The PICO screening procedure yielded 6 publications utilized as primary data. This review's findings suggest that the principal objective of antipsychotic treatment in people with schizophrenia is to attain remission swiftly and safely. Atypical antipsychotics are the primary treatment option for schizophrenia, specifically Risperidone, Aripiprazole, Olanzapine, Quetiapine, and Clozapine. The implementation of combination therapy is contingent upon the severity of schizophrenia symptoms. Using combinations of antipsychotics will lead to a wider range of receptor targets, which will make antipsychotics work better. In combination therapy, typical antipsychotics are utilized due to their swift alleviation of positive symptoms, including hallucinations and delusions. Paranoid schizophrenia for achieving early remission is capable of utilizing atypical monotherapy, combination of typical and atypical, combination of atypical and atypical antipsychotics in reaching remission with symptom assessments using PANSS and GAF.
Metabolic Syndrome and Side Effects of Atypical Antipsychotics in Schizophrenia: A Literature Review Nur Permatasari, Andinny; Yulistiani
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12452

Abstract

Atypical or second-generation antipsychotics are the most frequently prescribed antipsychotics due to their clinical efficacy and improved safety profile in the treatment of schizophrenia when compared to typical or first-generation antipsychotics. However, atypical antipsychotic drugs are associated with a high prevalence of adverse reactions, as well as side effects of metabolic syndrome. Schizophrenia is a chronic mental illness characterized by positive, negative, and cognitive dysfunctions. The objective of this review is to compare the impacts of atypical medication on MetS in patients with schizophrenia. A comprehensive analysis was conducted, including a literature review of the databases of Google Scholar, PubMed, and ScienceDirect for publications over the past decade. Seven articles were selected and reviewed for analysis. The analysis revealed that the use of atypical antipsychotics was associated with an increased risk of metabolic syndrome, while clozapine, olanzapine, and risperidone were associated with a higher risk of metabolic syndrome compared to other antipsychotics. The study also explores the mechanisms of metabolic syndrome, with a specific focus on the role of antipsychotics in disrupting glucose and lipid metabolism. This comprehensive study offers a nuanced understanding of the adverse effects of antipsychotic medications on the development of metabolic syndrome in individuals diagnosed with schizophrenia. This review revealed that the use of atypical antipsychotics in the treatment of schizophrenia can increase the risk of metabolic syndromes such as weight gain, dyslipidemia, hypertension, and diabetes. The primary limitation of this review is the high heterogeneity among studies, as they employed varying definitions of metabolic syndrome and included diverse sample characteristics.
Effects of Atorvastatin on Lipid Profiles and CETP (Cholesteryl Ester Transfer Protein) Levels in Pediatric Patients with Refractory Nephrotic Syndrome Pondawinata, Marizki; Yulistiani; Asmaningsih, Ninik
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.13734

Abstract

Atorvastatin is one of the statin groups indicated for curing and healing in pediatric with hyperlipidemia because it has high potential and safe with  less drug side effects. Several studies have reported the impact of atorvastatin on CETP levels, however the findings remain inconclusive. This study aimed to assess the effect of atorvastatin on lipid profiles and CETP levels in pediatrics patients with refractory nephrotic syndrome and hyperlipidemia. A double-blind, randomized clinical trial (RCT) using pre- and post- test design was conducted over for 4 weeks, involving the treatment group (atorvastatin) and the control group (placebo). The research took place at the pediatric nephrology outpatient clinic of Dr. Soetomo Hospital from December 2019 to March 2020. Baseline assessments at week 0 included measurements of total cholesterol, LDL, HDL, TG, CETP, and other laboratory parameters. Follow-up testing was performed after 4 weeks. The difference in average total cholesterol and LDL at week 0 and week 4 in the control group and the treatment group was significant (p <0.05). Giving atorvastatin reduced total cholesterol (29.2%), LDL cholesterol (30.8%), TG level (7.5%), and did not yet have an increase in HDL cholesterol levels. The mean CETP level in the treatment group were not significant differences despite a decrease in CETP level of 8%. Patients giving atorvastatin showed a relationship between changes in CETP level with LDL level and total cholesterol. These findings suggest that atorvastatin significantly lowers total cholesterol, LDL, and CETP levels in pediatric refractory nephrotic syndrome with hyperlipidemia.
Co-Authors Asmaningsih, Ninik Cotama, Cahana Rastra Dharliana Hardjowikarto Kuswandi, Nabila Aulia Yasmin Nur Permatasari, Andinny Pondawinata, Marizki Siti Khumayah