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All Journal Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding Kapuas
Ningsih, Tria
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Screening the Activity of Epigallocatechin Gallate as a Colorectal Anticancer Agent: In Silico and ADMET/Pharmacokinetic Studies Setiadi, Prismo Bagas; Alamsyah, Maura Shavira; Ningsih, Tria; Fajriyah, Qatrunada; Febriansah, Rifki
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 3 No. 2 (2024): Crafting Innovation for Global Benefit
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/umygrace.v3i2.602

Abstract

Introduction - Colorectal cancer is one of the third ranked cancers in Indonesia and has a high level of malignancy. The bioactive compound Epigallocatechin Gallate (EGCG) is known to have antioxidant and cytotoxic activity, so it has the potential to be developed as an anticancer agent. Purpose - This study aims to determine the potential of EGCG compounds as anticancer in silico. Methodology/Approach - The in-silico tests used are molecular docking and ADMET/Pharmacokinetic profiles using biosig pkcsm.Finding - The results of the respective binding affinities formed from EGCG compounds with the target protein affinities of COX-2 and Caspace-3 are -9.2 and -5.4 which are better links between EGCG and Caspace. The Lipinski rule show that the epigallocatecin compound has strength to absorb is 47%. This indicates that EGCG has the potential as a candidate for colorectal anticancer drugs with poor absorption. Originality/Value/Implications – In Silico, many studies have been carried out, but it is still rare to combine molecular docking methods with pKCSM to determine the solubility properties of compounds. The prospect of this research can become a basic or key for developing ECGC compounds into preparations because they have low bioavailability and can be continued in in vitro and in vivo research.
Pengadaan Perahu Motor Klotok Sebagai Transportasi Pemadam Kebakaran Sungai di Pemukiman Bantaran Sungai di Kelurahan Benua Melayu Laut Kecamatan Pontianak Selatan Arena, Azza; Sarpawi, Sarpawi; Widhiastuti, Rahayu; Ningsih, Tria
Kapuas Vol. 2 No. 2 (2022): Kapuas : Jurnal Publikasi Pengabdian Pada Masyarakat
Publisher : Politeknik Negeri Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31573/jk.v2i2.456

Abstract

Based on the ground figure data, it can be seen that the number of buildings in riverbank settlements has poor spatial planning with a fairly high density, especially in riverbank areas, where many buildings are above the river. Residential houses in the Bantaran Sungai settlement are residential houses that are densely populated and reach access to one residential house and another using old and weathered wooden snaps with several criteria including: residential houses located above the river, residential houses that are not livable. density of residential houses that are difficult to reach in the event of a fire and drowning of residents. community service implementation activities (PPM) Pontianak State Polytechnic 2021 Procurement of klotok motorboats as river firefighting transportation: Boat 4 meters long, 1.5 meters wide, with timbau board wood material, Using 4 cans of oil paint, Fire pump, boat engine.
Co-Authors Alamsyah, Maura Shavira Arena, Azza Fajriyah, Qatrunada Rahayu Widhiastuti Rifki Febriansah Sarpawi, Sarpawi Setiadi, Prismo Bagas