Buharman, Borries Foresto
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Validation of C-Reactive Protein and CURB-65 in The FirstHospital Admission Community Acquired Pneumonia Patient asA Predictor 30 Days Mortality Buharman, Borries Foresto; Pitoyo, Ceva Wicaksono; Singh, Gurmeet; Koesnoe, Sukamto
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 1
Publisher : UI Scholars Hub

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Child Turcotte Pugh Score, diastolic dysfunction, liver cirrhosis, liver dysfunction
Diagnosis dan Manajemen Thyroid Storm dengan Komplikasi Kardiak: Laporan Kasus Kanaya, Ni; Buharman, Borries Foresto
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 3 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i3.37093

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Thyroid Storm (TS) merupakan keadaan hipermetabolik akut darurat langka, ditandai dengan kegagalan multipel organ, yang dapat terjadi dengan atau tanpa diagnosis tirotoksikosis sebelumnya. Diagnosis dan penanganan tepat sangatlah penting untuk mencegah morbiditas dan mortalitas. Seorang wanita, 26 tahun, dengan keluhan dada berdebar disertai sesak, demam hilang timbul, berkeringat sepanjang hari, gelisah, mual, dan muntah sejak 2 minggu SMRS yang semakin buruk 3 hari SMRS. Pasien memiliki riwayat hipertensi, namun riwayat hipertiroid tidak diketahui. Pada pemeriksaan fisik, tekanan darah 110/70 mmHg, nadi 146x/menit, pernafasan 30x/menit, suhu 38,9°C, exophthalmos, goiter, ronki basah halus paru bilateral dan tremor. Hasil EKG didapatkan AF RVR dan hasil rontgen toraks menunjukkan kardiomegali. Hasil ekokardiografi menunjukkan LVH dengan EF 47% dan mild moderate regurgitasi mitral. Hasil FT4: 7,77 ng/dL dan TSH: 0,05 mIU/mL. Burch Wartofksy Point Scale pasien sebesar 85. Terapi awal IGD diberikan O2 NC 3 LPM, Paracetamol 1gr IV, Omeprazole 40mg IV, Ondansetron 4mg IV, Digoxin 0,50mg IV, Warfarin tablet 1x2mg, dan Candesartan tablet 1x8mg. Setelah keluar hasil TSH dan FT4, diberikan tambahan PTU loading 600mg, dilanjutkan dengan 4x200mg, Propanolol loading 40mg, dilanjutkan dengan 4x20mg, Dexamethasone 2x5mg IV, dan Furosemide 1x20mg IV. Pasien mengalami TS yang disebabkan oleh untreated hyperthyroidism. Dengan tingginya morbiditas dan mortalitas TS, resusitasi darurat sangat diperlukan, sambil menentukan dan mengobati pemicu yang mendasari. Penatalaksanaan TS meliputi stabilisasi kardiovaskular, pemberian steroid, tionamida, penghambat beta, pengobatan hipertermia dan agitasi. Identifikasi TS yang cepat, manajemen tepat dan adekuat dapat meningkatkan kesintasan pasien dengan komplikasi kardiak.
Laporan Kasus Hipokalemi Periodik Paralisis pada Pasien dengan Graves’ Disease Sirait, Anggi Cahaya Millenia S; Buharman, Borries Foresto; Putri, Adinda Zhafira Dyanti; Putri, Derby Ayudhia Utami Iskandar
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Hypokalemia periodic paralysis (HPP) characterized by episodes of flaccid weakness or paralysis that may be associated with abnormalities of the serum potassium level. HPP often associated with hyperthyroidism and Graves’ disease. HPP prevalence is 1 in 100.000. Each individual has different clinical manifestations, so it’s necessary to adjust therapy based on the etiology. This case report was developed to provide more information regarding Graves’ disease, considering lack of information about management and description of HPP with Graves’ disease. A 27-year-old male with sudden weakness in both legs radiating to upper extremity, shortness of breath, palpitations, and sweating. Over the last 2 months, the patient’s weight has dropped drastically even though his appetite was increased. There were no complaints of nausea, vomiting, or increased frequency of defecation and urination. Previously, the patient had the similar experiences and received potassium transfusion twice. The patients revealed tachycardia, diffuse thyroid gland, fine hand tremor, superior motor streght 222/222 and inferior 111/111, hypokalemia (1.40 mmol/L), T4 total 197.80 nmol/L, and fluorescence T4 >320 m/U/mL. Graves’ disease that has become thyrotoxicosis can be accompanied by a picture of HPP or also called thyrotoxicosis periodic paralysis (TPP). Hypokalemia in TPP are not caused by potassium loss but due to intracellular potassium movement, so there’s a high possibility to hyperkalemia rebound. Treatment of TTP due to Grave’s disease is to prevent potassium transfer by administering beta blocker, potassium replacement, and treating hyperthyroidism.